2-<2-(2-hydroxyethoxy)-ethyl>-1,3-dioxolane | 83490-15-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧戊环
• 英文名称: 2-<2-(2-hydroxyethoxy)-ethyl>-1,3-dioxolane
• 英文别名: 2-<2-(2-hydroxyethoxy)ethyl>-1,3-dioxalane；2-<2-(2-hydroxyethoxy)ethyl>-1,3-dioxolane；2-(2-[1,3]dioxolan-2-yl-ethoxy)-ethanol；2-(2-[1,3]Dioxolan-2-yl-aethoxy)-aethanol；2-(3,6-dioxa-hexyl)-1,3-dioxolane；2-[2-(2-Hydroxyethoxy)ethyl]-1,3-dioxolane；2-[2-(1,3-Dioxolan-2-yl)ethoxy]ethanol
• CAS: 83490-15-7
• 化学式: C₇H₁₄O₄
• 分子量: 162.186
• InChiKey: RHLBPAKKUQILTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-<2-(2-hydroxyethoxy)-ethyl>-1,3-dioxolane 在 硫酸 甲醇 、 sodium hydroxide 、 溶剂黄146 作用下， 以 水 为溶剂， 反应 17.0h， 生成 3-乙氧基丙醛
  参考文献：
  名称：

  Espinosa, Antonio; Gallo, Miguel A.; Campos, Joaquin, Bulletin de la Societe Chimique de France, 1983, vol. 2, # 9-10, p. 265 - 268

  摘要：

  DOI：
• 作为产物：
  描述：

  丙烯醛 、 乙二醇 在 盐酸 作用下， 生成 2-<2-(2-hydroxyethoxy)-ethyl>-1,3-dioxolane
  参考文献：
  名称：

  DE669805

  摘要：

  公开号：

文献信息

• Acetalization of α,β-unsaturated carbonyl compounds catalyzed by complexes of Pt(II)
  作者：Enrico Nieddu、Maurizio Cataldo、Francesco Pinna、Giorgio Strukul

  DOI：10.1016/s0040-4039(99)01419-7

  日期：1999.9

  sufficiently Lewis acidic to catalyze the acetalization of aldehydes and ketones. α,β-Unsaturated substrates can be easily acetalized with ethylene glycol under mild conditions in high yield and avoiding side reactions leading to formation of undesired by-products arising from the nucleophilic addition to the carboncarbon double bond conjugated to the carbonyl group. A comparison of the behavior of a Pt

  一类Pt（II）的阳离子二膦配合物具有足够的路易斯酸性，可以催化醛和酮的缩醛化。α，β-不饱和底物可以在温和的条件下容易地用乙二醇缩醛化，收率很高，并且避免了副反应，该副反应导致形成不希望的副产物，该副产物是由与羰基共轭的碳碳双键的亲核加成而形成的。在相同条件下，Pt络合物相对于PTSA作为催化剂的行为比较表明，在许多情况下，前者具有优越的选择性。
• 5-fluorouracil derivatives. 1. Acyclonucleosides through a tin (IV) chloride-mediated regiospecific ring opening of alkoxy-1,4-diheteroepanes
  作者：J. Campos、M.J. Pineda、J.A. Gómez、A. Entrena、M.A. Trujillo、M.A. Gallo、A. Espinosa

  DOI：10.1016/0040-4020(96)00439-5

  日期：1996.6

  and the use of tin (IV) chloride, capable of a 1,4-chelation, seem to impose their influence in the regiospecific ring opening of 1a-g. The conformational analyses carried out on 2b and (1R,3R)-2e and (1R,3S)-2e clearly indicate that the N1(sp2)-C1-C2-C3 moiety tends to fold in a gauche conformation. The antitumour activities of compounds 2b-g were assessed against HEp human cells showing that 2c is 4-fold

  5-氟尿嘧啶在室温下在氯化锡（IV），三甲基氯硅烷和六甲基二硅氮烷的存在下与七元缩醛1a-g反应，得到1-[[3-（2-（羟乙基杂）-1-烷氧基]烷基] -5-氟尿嘧啶2A-F和1 - [2-（3-羟基丙氧基）-1-异丙氧基]乙基} -5-氟尿嘧啶2克在31-86％的产率。杂原子在环缩醛的1位上的存在和氯化锡（IV）能够进行1,4-螯合，似乎在1a-g的区域特异性开环中施加了它们的影响。对2b和（1 R，3 R）-2e和（1 R，3S）-2e清楚地表明，N 1（sp 2）-C 1 -C 2 -C 3部分倾向于以薄纱构象折叠。评估化合物2b-g对HEp人类细胞的抗肿瘤活性，显示2c的活性是5-FU的4倍。与5-FU的毒性作用相比，所研究的药物未显示任何明显的毒性。
• Derivatized and/or crosslinked products from acetal- and
  申请人：National Starch and Chemical Investment Holding Corporation

  公开号：US05049634A1

  公开（公告）日：1991-09-17

  A derivatized graft polymer of a polysaccharide, a crosslinked graft polymer of a polysaccharide, and a derivatized and crosslinked graft polymer of a polysaccharide are prepared. The derivatized polymer has the structure Sacch-g-[(M--CH.dbd.N--Y).sub.x -g-[(M).sub.q ]; the crosslinked polymer has the structure Sacch-g-[(M--CH.dbd.N).sub.z -P].sub.w -g-[(M).sub.q ] or Sacch-g-[(M--CH.dbd.C).sub.z -P].sub.w -g-[(M).sub.q ]; the derivatized and crosslinked polymer has the structure Sacch-g-[(M--CH.dbd.N--Y).sub.x ]-g-[(M--CH.dbd.N)-P]-g-[(M).sub.q ] or Sacch-g-[(M--CH.dbd.N--Y).sub.x ]-g-[(M--CH.dbd.C).sub.z -P].sub.w -g-[(M).sub.q ]. Sacch represents a polysaccharide such as starch, gum, or cellulose; g-represents a graft; M represents one or more ethylenically or allylically unsaturated monomers, at least one of which contains an acetal or aldehyde; P represents a multivalen residue from a reagent containing more than one primary amine group or ketone group; --N.dbd. represents the group formed when one primary amine group of P reacts with the acetal or aldehyde group of the monomer repecting unit M; 13 CH.dbd. represents the group formed when one of the ketone groups of P reacts with the acetal or aldehyde group of the monomer repeating unit M; x is at least 1; z is at least 2; w is at least 1; and q is 0 or greater.

  制备了一种多糖衍生物接枝聚合物、一种多糖交联接枝聚合物和一种多糖衍生物交联接枝聚合物。衍生物聚合物的结构为Sacch-g-[(M--CH.dbd.N--Y).sub.x -g-[(M).sub.q]；交联聚合物的结构为Sacch-g-[(M--CH.dbd.N).sub.z -P].sub.w -g-[(M).sub.q]或Sacch-g-[(M--CH.dbd.C).sub.z -P].sub.w -g-[(M).sub.q]；衍生和交联聚合物的结构为Sacch-g-[(M--CH.dbd.N--Y).sub.x]-g-[(M--CH.dbd.N)-P]-g-[(M).sub.q]或Sacch-g-[(M--CH.dbd.N--Y).sub.x]-g-[(M--CH.dbd.C).sub.z -P].sub.w -g-[(M).sub.q]。Sacch代表淀粉、胶或纤维素等多糖；g代表接枝；M代表一个或多个具有乙烯或烯丙基不饱和单体，其中至少一个含有缩醛或醛基；P代表来自含有多个主要胺基或酮基的试剂的多价残基；--N.dbd.代表当P的一个主要胺基与单体重复单元M的缩醛或醛基反应时形成的基团；13 CH.dbd.代表当P的一个酮基与单体重复单元M的缩醛或醛基反应时形成的基团；x至少为1；z至少为2；w至少为1；q为0或更大。
• Polysaccharide graft polymers containing acetal groups and their
  申请人：National Starch and Chemical Corporation

  公开号：US04866151A1

  公开（公告）日：1989-09-12

  Polysaccharide graft polymers which comprise an acetal-containing or aldehyde-containing homopolymer or copolymer grafted to a polysaccharide base have been prepared. The monomer repeating units in the homopolymer are derived from one or more ethylenically or allylically unsaturated monomers containing an acetal group or aldehyde group; The monomer repeating units in the copolymer are derived from the above monomer and derived from one or more ethylenically or allylically unsaturated monomers other than the acetal-containing or aldehyde-containing monomer. A and A' are independently a lower alkyl or A and A' together form at least a 5-membered cyclic acetal; with the proviso that the graft polymer contain no ##STR1## groups when the aldehyde groups are present. The aldehyde-containing graft polymers are useful for imparting wet strength to paper. Various novel acetal- and aldehyde-containing monomers have also been prepared; they can be graft polymerized to polysaccharide substrates or polymerized by conventional emulsion polymerization techniques with vinyl polymerizable monomers.

  已经制备出了包含缩醛基或醛基的同聚物或共聚物嫁接到多糖基底上的多糖嫁接聚合物。同聚物中的单体重复单元来自于一个或多个含有缩醛基或醛基的乙烯基或烯丙基不饱和单体；共聚物中的单体重复单元来自于上述单体和来自于一个或多个不含缩醛基或醛基单体的乙烯基或烯丙基不饱和单体。A和A'分别是较低的烷基或A和A'一起形成至少一个5元环缩醛基；但是嫁接聚合物在存在醛基时不包含##STR1##基团。含有醛基的嫁接聚合物对于赋予纸张湿强度很有用。还制备了各种新型含缩醛基和醛基的单体；它们可以嫁接聚合到多糖基底上或通过常规乳液聚合技术与乙烯基可聚合单体共聚合。
• Polysaccaride derivatives containing aldehyde groups, corresponding acetals and use as paper additives
  申请人：National Starch and Chemical Investment Holding Corporation

  公开号：EP0232851A2

  公开（公告）日：1987-08-19

  Polysaccharide aldehydes having the formula Sacch-O-CH2-CH = CH-CHO, such as starch, cellulose, and gum aldehydes, are useful for imparting wet, dry, or temporary wet strength to paper. They are prepared by a non-oxidative method which involves reacting the polysaccaride base, in the presence of alkali, with a derivatizing acetal reagent and then hydrolyzing the acetal by adjusting the pH to less than 7. In the formulas, n is 1-3; R" and R'2 are independently an alkyl, aryl, aralkyl, or alkaryl group when n is 1, R" or R'2 is one of the groups when n is 2, or R" and R12 are not present when n is 3; R13 is an alkyl group or an aralkyl group; R14 and R15 are individually a hydrogen or a methyl group; R16, R", and R18 are individually an alkyl group; y- is an anion; and A and A' are lower alkyls or together form at least a 5-membered cyclic acetal.

  具有 Sacch-O-CH2-CH = CH-CHO 式的多糖醛、 如淀粉、纤维素和树胶醛，可用于赋予纸张湿强度、干强度或临时湿强度。它们是通过非氧化法制备的，即在碱存在的情况下，使聚羧酸基与衍生缩醛试剂反应，然后通过调节 pH 值至 7 以下使缩醛水解。在配方中，n 为 1-3；当 n 为 1 时，R "和 R'2 独立地为烷基、芳基、芳烷基或烷芳基，当 n 为 2 时，R "或 R'2 为其中一个基团，或当 n 为 3 时，R "和 R12 不存在；R13 为烷基或芳烷基；R14 和 R15 分别是氢或甲基；R16、R "和 R18 分别是烷基；y- 是阴离子；以及 A 和 A'是低级烷基或共同形成至少 5 元环缩醛。