1-(3,4-dichlorophenyl)-1H-1,2,4-triazole | 1226897-82-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(3,4-dichlorophenyl)-1H-1,2,4-triazole
• 英文别名: 1-(3,4-Dichlorophenyl)-1,2,4-triazole；1-(3,4-dichlorophenyl)-1,2,4-triazole
• CAS: 1226897-82-0
• 化学式: C₈H₅Cl₂N₃
• 分子量: 214.054
• InChiKey: GQRAKYNGLVKFNZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(3,4-dichlorophenyl)-1H-1,2,4-triazole 在 N-溴代丁二酰亚胺(NBS) 、 过氧化苯甲酰 作用下， 以 四氯化碳 为溶剂， 反应 12.0h， 以86%的产率得到5-bromo-1-(3,4-dichlorophenyl)-1H-1,2,4-triazole
  参考文献：
  名称：

  Synthesis and Antitumor Activity of 1,5-Disubstituted 1,2,4-Triazoles as Cis-Restricted Combretastatin Analogues

  摘要：

  A series of 1-aryl-5-(3',4',5'-trimethoxyphenyl) derivatives and their related 1-(3',4',5'-trimethoxyphenyl)5-aryl-1,2,4-triazoles, designed as cis-restricted combretastatin analogues, were synthesized and evaluated for antiproliferative activity, inhibitory effects on tubulin polymerization, cell cycle effects, and apoptosis induction. Their activity was greater than, or comparable with, that of the reference compound CA-4. Flow cytometry studies showed that HeLa and Jurkat cells treated with the most active compounds 4l and 4o were arrested in the G2/M phase of the cell cycle in a concentration dependent manner. This effect was accompanied by apoptosis of the cells, mitochondrial depolarization, generation of reactive oxygen species, activation of caspase-3, and PA RP cleavage. Compound 41 was also shown to have potential antivascular activity, since it induced endothelial cell shape change in vitro and disrupted the sprouting of endothelial cells in the chick aortic ring assay.

  DOI：

  10.1021/jm100245q
• 作为产物：
  描述：

  (3,4-二氯苯基)肼 、 formamide 160.0 ℃ 、1.72 MPa 条件下， 反应 0.17h， 以79%的产率得到1-(3,4-dichlorophenyl)-1H-1,2,4-triazole
  参考文献：
  名称：

  Microwave-Assisted Catalyst-Free Synthesis of Substituted 1,2,4-Triazoles

  摘要：

  A simple, efficient, and mild method has been developed for the synthesis of substituted 1,2,4-triazoles from hydrazines and formamide under microwave irradiation. The reaction proceeds smoothly in the absence of a catalyst and shows excellent functional-group tolerance.

  DOI：

  10.1055/s-0034-1379734

文献信息

• Synthesis and Antitumor Activity of 1,5-Disubstituted 1,2,4-Triazoles as Cis-Restricted Combretastatin Analogues
  作者：Romeo Romagnoli、Pier Giovanni Baraldi、Olga Cruz-Lopez、Carlota Lopez Cara、Maria Dora Carrion、Andrea Brancale、Ernest Hamel、Longchuan Chen、Roberta Bortolozzi、Giuseppe Basso、Giampietro Viola

  DOI：10.1021/jm100245q

  日期：2010.5.27

  A series of 1-aryl-5-(3',4',5'-trimethoxyphenyl) derivatives and their related 1-(3',4',5'-trimethoxyphenyl)5-aryl-1,2,4-triazoles, designed as cis-restricted combretastatin analogues, were synthesized and evaluated for antiproliferative activity, inhibitory effects on tubulin polymerization, cell cycle effects, and apoptosis induction. Their activity was greater than, or comparable with, that of the reference compound CA-4. Flow cytometry studies showed that HeLa and Jurkat cells treated with the most active compounds 4l and 4o were arrested in the G2/M phase of the cell cycle in a concentration dependent manner. This effect was accompanied by apoptosis of the cells, mitochondrial depolarization, generation of reactive oxygen species, activation of caspase-3, and PA RP cleavage. Compound 41 was also shown to have potential antivascular activity, since it induced endothelial cell shape change in vitro and disrupted the sprouting of endothelial cells in the chick aortic ring assay.
• Microwave-Assisted Catalyst-Free Synthesis of Substituted 1,2,4-Triazoles
  作者：Anil Kumar、Ganesh Shelke、V. Rao、Mukund Jha、T. Cameron

  DOI：10.1055/s-0034-1379734

  日期：——

  A simple, efficient, and mild method has been developed for the synthesis of substituted 1,2,4-triazoles from hydrazines and formamide under microwave irradiation. The reaction proceeds smoothly in the absence of a catalyst and shows excellent functional-group tolerance.