3,5-bis(3',5'-dimethyl-1'-pyrazolylcarbonyl)-2,6-dimethylpyridine | 1354571-13-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3,5-bis(3',5'-dimethyl-1'-pyrazolylcarbonyl)-2,6-dimethylpyridine
• 英文别名: [5-(3,5-Dimethylpyrazole-1-carbonyl)-2,6-dimethylpyridin-3-yl]-(3,5-dimethylpyrazol-1-yl)methanone
• CAS: 1354571-13-3
• 化学式: C₁₉H₂₁N₅O₂
• 分子量: 351.408
• InChiKey: WIYZGLCHNFFBPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  82.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3,5-bis(3',5'-dimethyl-1'-pyrazolylcarbonyl)-2,6-dimethylpyridine 、 2,4-二甲基苯胺 在 溶剂黄146 作用下， 以 甲苯 为溶剂， 反应 1.0h， 以91%的产率得到3,5-bis[N-(2,4-dimethylphenyl)carbamoyl]-2,6-dimethylpyridine
  参考文献：
  名称：

  Convenient Synthesis of 3,5-Biscarbamoyl-pyridine Derivatives

  摘要：

  AbstractAn efficient and convenient method for synthesis of 3,5‐bis‐carbamoyl‐2,6‐dimethylpyridine derivatives was achieved in good to excellent yields by reaction of anilines with 3,5‐bis(3′,5′‐dimethyl‐1′‐pyrazolyl‐carbonyl)‐2,6‐dimethylpyridine, in which pyrazoles served as leaving groups. The structures of products were confirmed by spectra data and microanalysis.

  DOI：

  10.1002/cjoc.201180367
• 作为产物：
  描述：

  二氢吡啶 在 对甲苯磺酸 、 一水合肼 、 溶剂黄146 、 sodium nitrite 作用下， 以 乙醇 、 氯仿 、 水 为溶剂， 反应 9.0h， 生成 3,5-bis(3',5'-dimethyl-1'-pyrazolylcarbonyl)-2,6-dimethylpyridine
  参考文献：
  名称：

  Convenient Synthesis of 3,5-Biscarbamoyl-pyridine Derivatives

  摘要：

  AbstractAn efficient and convenient method for synthesis of 3,5‐bis‐carbamoyl‐2,6‐dimethylpyridine derivatives was achieved in good to excellent yields by reaction of anilines with 3,5‐bis(3′,5′‐dimethyl‐1′‐pyrazolyl‐carbonyl)‐2,6‐dimethylpyridine, in which pyrazoles served as leaving groups. The structures of products were confirmed by spectra data and microanalysis.

  DOI：

  10.1002/cjoc.201180367

文献信息

• Convenient Synthesis of 3,5-Biscarbamoyl-pyridine Derivatives
  作者：Xiayun Wang、Yiwen Zhu、Min Zhang、Dongliang Lu、Qun Qian、Yali Chen、Weiguo Cao、Liping Song、Hongmei Deng

  DOI：10.1002/cjoc.201180367

  日期：2011.10

  AbstractAn efficient and convenient method for synthesis of 3,5‐bis‐carbamoyl‐2,6‐dimethylpyridine derivatives was achieved in good to excellent yields by reaction of anilines with 3,5‐bis(3′,5′‐dimethyl‐1′‐pyrazolyl‐carbonyl)‐2,6‐dimethylpyridine, in which pyrazoles served as leaving groups. The structures of products were confirmed by spectra data and microanalysis.