2-(2,6-dimethylphenylimino)-N-(4-nitrophenyl)-4-phenylbutanamide | 1392826-43-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2,6-dimethylphenylimino)-N-(4-nitrophenyl)-4-phenylbutanamide
• 英文别名: 2-(2,6-dimethylphenyl)imino-N-(4-nitrophenyl)-4-phenylbutanamide
• CAS: 1392826-43-5
• 化学式: C₂₄H₂₃N₃O₃
• 分子量: 401.465
• InChiKey: RKKPMLTZIYNVMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  87.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,6-二甲基苯基异腈 、 异氰酸对硝基苯 、 乙基溴苯 在 六甲基磷酰三胺 、 samarium diiodide 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以86%的产率得到2-(2,6-dimethylphenylimino)-N-(4-nitrophenyl)-4-phenylbutanamide
  参考文献：
  名称：

  One-Pot, Three-Component Coupling Approach to the Synthesis of α–Iminocarboxamides

  摘要：

  A one-pot, three-component coupling was accomplished via the nucleophilic addition of an alkylsamarium(III) species to isocyanides and the subsequent addition of the resultant imidoyl samarium(III) species to isocyanates under mild conditions for the formation of alpha-iminocarboxamides. The developed sequential C-C bond-forming procedure enabled the rapid synthesis of the alpha-iminocarboxamides in good to excellent yields from readily available starting materials.

  DOI：

  10.1021/ol3017337

文献信息

• One-Pot, Three-Component Coupling Approach to the Synthesis of α–Iminocarboxamides
  作者：Hisashi Masui、Shinichiro Fuse、Takashi Takahashi

  DOI：10.1021/ol3017337

  日期：2012.8.17

  A one-pot, three-component coupling was accomplished via the nucleophilic addition of an alkylsamarium(III) species to isocyanides and the subsequent addition of the resultant imidoyl samarium(III) species to isocyanates under mild conditions for the formation of alpha-iminocarboxamides. The developed sequential C-C bond-forming procedure enabled the rapid synthesis of the alpha-iminocarboxamides in good to excellent yields from readily available starting materials.