(E)-13,13,13-trifluorotridec-11-en-2-one | 1415585-54-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (E)-13,13,13-trifluorotridec-11-en-2-one
• CAS: 1415585-54-4
• 化学式: C₁₃H₂₁F₃O
• 分子量: 250.304
• InChiKey: SGPSGZCOPXLFMC-PKNBQFBNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  17
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  十二碳-11-烯-2-酮 、 三氟碘甲烷 在 tris(1,10-phenanthroline)ruthenium(II) dichloride 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 乙腈 为溶剂， 以81%的产率得到(E)-13,13,13-trifluorotridec-11-en-2-one
  参考文献：
  名称：

  Trifluoromethylation of Alkenes by Visible Light Photoredox Catalysis

  摘要：

  A method for trifluoromethylation of alkenes has been developed employing visible light photoredox catalysis with CF3I, Ru(Phen)(3)Cl-2, and DBU. This process works especially well for terminal alkenes to give alkenyl-CF3 products with only E-stereochemistry. The mild reaction conditions enable the trifluoromethylation of a range of alkenes that bear various functional groups.

  DOI：

  10.1021/jo3022346

文献信息

• Trifluoromethylation of Alkenes by Visible Light Photoredox Catalysis
  作者：Naeem Iqbal、Sungkyu Choi、Eunjin Kim、Eun Jin Cho

  DOI：10.1021/jo3022346

  日期：2012.12.21

  A method for trifluoromethylation of alkenes has been developed employing visible light photoredox catalysis with CF3I, Ru(Phen)(3)Cl-2, and DBU. This process works especially well for terminal alkenes to give alkenyl-CF3 products with only E-stereochemistry. The mild reaction conditions enable the trifluoromethylation of a range of alkenes that bear various functional groups.