chromogen

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: chromogen
• 英文别名: 5-[3-(6-hydroxy-4-oxo-2-sulfanylidene-1H-pyrimidin-5-yl)prop-2-enylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
• 化学式: C₁₁H₈N₄O₄S₂
• 分子量: 324.341
• InChiKey: HRWTWBCVBXYDIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  184
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4,6-二羟基-2-巯基嘧啶 、 丙二醛 在 盐酸 、 sodium chloride 作用下， 以 水 为溶剂， 反应 1.0h， 生成 chromogen
  参考文献：
  名称：

  A rapid spectrofluorimetric method for the determination of malondialdehyde in human plasma after its derivatization with thiobarbituric acid and vortex assisted liquid–liquid microextraction

  摘要：

  一种快速的荧光光谱法，用于在血浆中测定丙二醛。在血浆中加入硫代巴比妥酸衍生化，然后进行涡旋辅助液-液微萃取。

  DOI：

  10.1039/c5ra22079c

文献信息

• Antiinflammatory properties of betulinic acid and xylopic acid in the carrageenan-induced pleurisy model of lung inflammation in mice
  作者：Edmund Ekuadzi、Robert P. Biney、Charles K. Benneh、Bismark Osei Amankwaa、Jonathan Jato

  DOI：10.1002/ptr.5993

  日期：2018.3

  This study investigated the antiinflammatory properties of betulinic acid (BA) and xylopic acid (XA) extracted from Margaritaria discoidea and Xylopia aethiopica, respectively. M. discoidea and X. aethiopica are plants native in Ghana and the West‐African region and used traditionally to treat different pathologies including inflammatory conditions. The antiinflammatory effect of BA and XA was established

  本研究分别研究了从 Margaritaria discoidea 和 Xylopia aethiopica 中提取的桦木酸 (BA) 和木酸 (XA) 的抗炎特性。M. discoidea 和 X. aethiopica 是原产于加纳和西非地区的植物，传统上用于治疗不同的病理，包括炎症。BA 和 XA 的抗炎作用是通过使用角叉菜胶诱导的小鼠胸膜炎症模型的体内试验确定的。此外，还评估了 BA 和 XA 在反应性氧化测定中增加过氧化氢酶、超氧化物歧化酶、谷胱甘肽水平和降低脂质过氧化水平的能力。此外，量化了 XA 和 BA 防止潜在肺组织损伤的能力。用 BA 和 XA 预处理显着减少炎症迹象：角叉菜胶处理的肺组织中的中性粒细胞浸润、水肿和肺泡间隔增厚。此外，BA 或 XA 预处理降低了肺组织中脂质过氧化的程度，同时增加了体内过氧化氢酶、超氧化物歧化酶和谷胱甘肽的水平。相比之下，XA 在预防肺组织损伤方面比
• A vegetable oil derived chemodosimeter for the selective detection of Hg2+ in aqueous media: a potential green laboratory method
  作者：Swapnil Rohidas Jadhav、Kuthanapillil Jyothish、George John

  DOI：10.1039/c002651d

  日期：——

  An in situ-generated byproduct from the naturally occurring autoxidation of vegetable oil has been utilized to develop a thione-containing chemodosimeter for the selective detection of aqueous mercuric ions (Hg2+) at nanomolar concentrations through a one-pot synthesis/detection technique.

  利用植物油自然发生的自氧化产生的原位副产物开发了一种含硫酮的化学剂量计，用于通过一锅合成/检测技术选择性检测纳摩尔浓度的水汞离子 (Hg2+)。
• Effect of organic co-solvents in the evaluation of the hydroxyl radical scavenging activity by the 2-deoxyribose degradation assay: The paradigmatic case of α-lipoic acid
  作者：Andrea Brizzolari、Giuseppe M. Campisi、Enzo Santaniello、Nima Razzaghi-Asl、Luciano Saso、Mario C. Foti

  DOI：10.1016/j.bpc.2016.10.005

  日期：2017.1

  The 2-deoxyribose degradation assay (2-DR assay) is an in vitro method broadly used for evaluating the scavenging activity against the hydroxyl radical (HO center dot). One of the major drawbacks of the assay, however, is that only water soluble compounds can be tested for their radical-scavenging activity. Lipoic acid (LA) is an excellent scavenger of HO center dot but it exhibits a low solubility in the aqueous milieu of the 2-DR assay and a high tendency to polymerize under a variety of conditions. We used LA as a paradigmatic substrate to evaluate the effect of several organic co-solvents in increasing its solubility. Most of these solvents, however, demonstrated to be potent scavengers of HO center dot making their use in the 2-DR assay improper. On the other hand, acetonitrile showed a remarkably low reactivity toward HO center dot (rate constant similar to 8.7 x 10(6) M-1 s(-1)) which allowed us to use it as a co-solvent in the preparation of stock solutions of LA similar to 5 mM. We therefore evaluated the radical-scavenging activity of LA by the 2-DR assay in a relatively large range of concentrations, 1-200 mu M. We found that the rate constant for LA + HO center dot is diffusion-controlled (similar to 1 x 10(10) M-1 s(-1) in water at 25 degrees C) and uninfluenced by the presence of small quantities of acetonitrile. Therefore, the use of acetonitrile in the 2-DR assay does not interfere with the test and may increase the solubility of the radical scavengers. (C) 2016 Elsevier B.V. All rights reserved.