2-phenethyl-succinic acid 1-methyl ester | 708269-38-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-phenethyl-succinic acid 1-methyl ester
• 英文别名: 3-methoxycarbonyl-5-phenylvaleric acid；3-methoxycarbonyl-5-phenylpentanoic acid
• CAS: 708269-38-9
• 化学式: C₁₃H₁₆O₄
• 分子量: 236.268
• InChiKey: RBIYDRNKEWDLSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-phenethyl-succinic acid 1-methyl ester 在 三甲基乙酰氯 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  [EN] DERIVATIVES OF SUCCINIC AND GLUTARIC ACIDS AND ANALOGS THEREOF USEFUL AS INHIBITORS OF PHEX
  [FR] DERIVES D'ACIDES SUCCINIQUE ET GLUTARIQUE ET LEURS ANALOGUES UTILISES COMME INHIBITEURS DE PHEX

  摘要：

  公开号：

  WO2004050620A3
• 作为产物：
  描述：

  2-phenethyl-succinic acid 4-tert-butyl ester 1-methyl ester 在 三氟乙酸 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 2.0h， 生成 2-phenethyl-succinic acid 1-methyl ester
  参考文献：
  名称：

  [EN] DERIVATIVES OF SUCCINIC AND GLUTARIC ACIDS AND ANALOGS THEREOF USEFUL AS INHIBITORS OF PHEX
  [FR] DERIVES D'ACIDES SUCCINIQUE ET GLUTARIQUE ET LEURS ANALOGUES UTILISES COMME INHIBITEURS DE PHEX

  摘要：

  公开号：

  WO2004050620A3

文献信息

• NOVEL BISPHOSPHINE LIGAND
  申请人：WATANABE Michimasa

  公开号：US20080242534A1

  公开（公告）日：2008-10-02

  A compound represented by the following general formula (I): [wherein R 1 represents hydrogen atom, or an alkyl group, R 2 represents a hydroxyalkyl group, or a triarylmethyloxyalkyl group, or R 1 and R 2 combine together to represent —C(R 3 )(R 4 )— (R 3 and R 4 represent hydrogen atom, an alkyl group, or hydroxyl group, or R 3 and R 4 may combine together to represent oxo group), or —C(R 5 )(R 6 )—O—C(R 7 )(R 8 )— (R 5 to R 8 represent hydrogen atom, an alkyl group, or hydroxyl group, or R 5 and R 6 may combine together to represent oxo group, and R 7 and R 8 may combine together to represent oxo group); Ar 1 to Ar 4 independently represent an aryl group (the aryl group may have 1 to 5 of the same or different substituents), *1 to *4 indicate asymmetric carbons, and configurations are cis between *1 and *2, cis between *3 and *4, and trans between *2 and *3]. An optically active phosphine ligand which can be easily synthesized and gives a transition metal complex showing superior asymmetric catalyst activity is provided.

  提供了一个由以下一般式（I）表示的化合物：【其中R1代表氢原子，或烷基团，R2代表羟基烷基团，或三芳基甲氧基烷基团，或R1和R2结合在一起表示—C(R3)(R4)—（R3和R4代表氢原子，烷基团，或羟基，或R3和R4可以结合在一起表示酮基），或—C(R5)(R6)—O—C(R7)(R8)—（R5到R8代表氢原子，烷基团，或羟基，或R5和R6可以结合在一起表示酮基，R7和R8可以结合在一起表示酮基）；Ar1到Ar4独立地代表芳基（芳基可能具有1到5个相同或不同的取代基），*1到*4表示不对称碳，配置在*1和*2之间为顺式，*3和*4之间为顺式，*2和*3之间为反式】。提供了一种可以轻松合成并给出显示出优越不对称催化剂活性的过渡金属配合物的光学活性膦配体。
• Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex
  申请人：Gravel Denis

  公开号：US20060135480A1

  公开（公告）日：2006-06-22

  The present invention relates to derivatives of succinic and glutaric acids and analogues thereof, having the following general formula (I), useful as inhibitors of PHEX. These derivatives are useful for promoting generation of bone mass and treating or preventing diseases or conditions associated with a phosphate metabolism defect. Methods for preparation and intermediates are also disclosed.

  本发明涉及琥珀酸和戊二酸的衍生物及其类似物，具有以下一般式（I），可用作PHEX的抑制剂。这些衍生物有助于促进骨量的生成，并治疗或预防与磷酸盐代谢缺陷相关的疾病或病症。本发明还公开了制备方法和中间体。
• Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX
  申请人：Gravel Denis

  公开号：US20060287280A1

  公开（公告）日：2006-12-21

  The present invention relates to derivatives of succinic and glutaric acids and analogues thereof, having the following general formula: useful as inhibitors of PHEX. These derivatives are useful for promoting generation of bone mass and treating or preventing diseases or conditions associated with a phosphate metabolism defect. Methods for preparation and intermediates are also disclosed.

  本发明涉及琥珀酸和戊二酸及其类似物的衍生物，其具有以下一般式：用作PHEX的抑制剂。这些衍生物有助于促进骨量的生成，并用于治疗或预防与磷酸盐代谢缺陷有关的疾病或病况。本发明还公开了制备方法和中间体。
• DERIVATIVES OF SUCCINIC AND GLUTARIC ACIDS AND ANALOGS THEREOF USEFUL AS INHIBITORS OF PHEX
  申请人：Enobia Pharma Inc.

  公开号：EP1572645A2

  公开（公告）日：2005-09-14
• Bisphosphine ligands for asymmetric syntheses
  申请人：Daiichi Fine Chemical Co., Ltd.

  公开号：EP1975170B1

  公开（公告）日：2011-03-09