4-(3,5-dimethylphenoxy)-3-iodo-6-methyl-5-(tetrahydrofuran-2-ylmethoxymethyl)-pyridin-2(1H)-one | 1185189-12-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(3,5-dimethylphenoxy)-3-iodo-6-methyl-5-(tetrahydrofuran-2-ylmethoxymethyl)-pyridin-2(1H)-one
• 英文别名: 4-(3,5-Dimethylphenoxy)-3-iodo-6-methyl-5-[(tetrahydrofuran-2-ylmethoxy)methyl]pyridin-2(1H)-one；4-(3,5-dimethylphenoxy)-3-iodo-6-methyl-5-(oxolan-2-ylmethoxymethyl)-1H-pyridin-2-one
• CAS: 1185189-12-1
• 化学式: C₂₀H₂₄INO₄
• 分子量: 469.319
• InChiKey: RVSKLYOPGMSTOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  四氢糠醇 、 5-chloromethyl-3-iodo-6-methyl-4-(3,5-dimethylpheoxy)pyridin-2(1H)-one 在 potassium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 反应 15.0h， 生成 4-(3,5-dimethylphenoxy)-3-iodo-6-methyl-5-(tetrahydrofuran-2-ylmethoxymethyl)-pyridin-2(1H)-one
  参考文献：
  名称：

  Synthesis and Biological Evaluation of C-5 Methyl Substituted 4-Arylthio and 4-Aryloxy-3-Iodopyridin-2(1H)-one Type Anti-HIV Agents

  摘要：

  A series of C-5 methyl substituted 4-arylthio- and 4-aryloxy-3-iodopyridin-2(1H)-ones hits been synthesized its new pyridinone analogues for their evaluation as anti-HIV inhibitors. The optimization at the 5-position wits developed through an efficient use of the key intermediates 5-ethoxycarbonyl- and 5-cyano-pyridin-2(1H)-ones (14 and 15). Biological studies revealed that several compounds show potent HIV-1 reverse transcriptase inhibitory properties, for example, compounds 93 and 99 are active at 0.6-50 nM against wild type HIV-1 and a panel of major simple/double HIV mutant strains.

  DOI：

  10.1021/jm900802y

文献信息

• Synthesis and Biological Evaluation of C-5 Methyl Substituted 4-Arylthio and 4-Aryloxy-3-Iodopyridin-2(1<i>H</i>)-one Type Anti-HIV Agents
  作者：Jérôme Guillemont、Abdellah Benjahad、Said Oumouch、Laurence Decrane、Patrice Palandjian、Daniel Vernier、Laurence Queguiner、Koen Andries、Marie-Pierre de Béthune、Kurt Hertogs、David S. Grierson、Chi Hung Nguyen

  DOI：10.1021/jm900802y

  日期：2009.12.10

  A series of C-5 methyl substituted 4-arylthio- and 4-aryloxy-3-iodopyridin-2(1H)-ones hits been synthesized its new pyridinone analogues for their evaluation as anti-HIV inhibitors. The optimization at the 5-position wits developed through an efficient use of the key intermediates 5-ethoxycarbonyl- and 5-cyano-pyridin-2(1H)-ones (14 and 15). Biological studies revealed that several compounds show potent HIV-1 reverse transcriptase inhibitory properties, for example, compounds 93 and 99 are active at 0.6-50 nM against wild type HIV-1 and a panel of major simple/double HIV mutant strains.