3-oxo-N,N-dipropylbutaneamide | 25233-44-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-oxo-N,N-dipropylbutaneamide
• 英文别名: N,N-dipropyl-acetoacetamide；N,N-Dipropyl-acetoacetamid；Acetessigsaeure-dipropylamid；Acetessigsaeuredipropylamid；3-Oxo-n,n-dipropylbutanamide
• CAS: 25233-44-7
• 化学式: C₁₀H₁₉NO₂
• 分子量: 185.266
• InChiKey: MDGLAZHWDSJEJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-oxo-N,N-dipropylbutaneamide 生成 2,2-dichloro-acetoacetic acid dipropylamide
  参考文献：
  名称：

  DE1098939

  摘要：

  公开号：
• 作为产物：
  描述：

  双乙烯酮 、 二正丙胺 在 borate buffer 作用下， 以 乙腈 为溶剂， 反应 0.08h， 生成 3-oxo-N,N-dipropylbutaneamide
  参考文献：
  名称：

  Ru(bpy)₃³⁺Electrochemiluminescence Detection of Aliphatic and Aromatic Amines with Diketene

  摘要：

  提出了一种新的衍生化方法，用于基于电化学发光（ECL）与Ru(bpy)32+的脂肪族和芳香族胺的检测。样品中的胺类通过使用二酮酸酯衍生化为乙酰乙酰胺类衍生物。通过反相高效液相色谱（HPLC）结合Ru(bpy)32+的ECL检测对这些衍生物进行检测。

  DOI：

  10.1246/cl.2003.98

文献信息

• Fe(III) Complex Compounds For The Treatment And Prophylaxis Of Iron Deficiency Symptoms And Iron Deficiency Anemias
  申请人：Bark Thomas

  公开号：US20130109662A1

  公开（公告）日：2013-05-02

  The invention relates to iron(III) complex compounds and pharmaceutical compositions comprising them for the use as medicaments, in particular for the treatment and/or prophylaxis of iron deficiency symptoms and iron deficiency anemias.

  这项发明涉及铁（III）配合物和包括它们的药物组合物，用作药物，特别是用于治疗和/或预防缺铁症状和缺铁性贫血。
• 2,3-Dioximes of Various Substituted Acetoacetamides and Their Metal Chelates
  作者：Antonius Kettrup、Klaus Striegler

  DOI：10.1139/v74-101

  日期：1974.2.15

  Methods of preparing 2,3-dioximes of various substituted acetoacetamides are presented. The dissociation constants of these compounds and the stability constants of their metal chelates were determined by potentiometric pH measurements. The influence of the substituents of the amide group on the change of stability is discussed.

  提供了制备各种取代乙酰乙酰胺二肟的方法。通过电位滴定pH测量确定了这些化合物的解离常数和它们的金属螯合物的稳定常数。讨论了酰胺基团取代基对稳定性变化的影响。
• Octahydro-1H-pyrrolo\x9b3,2-g!and \x9b2,3-g!isoquinoline derivatives
  申请人：SmithKline Beecham S.p.A.

  公开号：US05731322A1

  公开（公告）日：1998-03-24

  Tricyclic derivatives of octahydroisoquinoline of formula (I), wherein n is zero or 1 and if n is zero, one of X or Y is NH, oxygen or sulphur, and the other is NH, CH or a R.sub.4 - or R.sub.5 -substituted carbon atom; if n is 1, then X and Y are both nitrogen, or one of them is nitrogen and the other is CH or an R.sub.4 - or R.sub.5 -substituted carbon atom, have selective receptor agonist or antagonist activity, and are of potential therapeutic utility as analgesics or immunomodulating and/or cardiovascular agents. ##STR1##

  式(I)的八氢异喹啉的三环衍生物，其中n为零或1，如果n为零，则X或Y之一为NH、氧或硫，另一个为NH、CH或R.sub.4-或R.sub.5-取代的碳原子；如果n为1，则X和Y都是氮，或其中一个是氮，另一个是CH或R.sub.4-或R.sub.5-取代的碳原子，具有选择性受体激动剂或拮抗剂活性，并具有潜在的治疗效用，可用作镇痛剂或免疫调节和/或心血管药物。
• Macromolecular Compounds Having Controlled Stoichiometry
  申请人：Krippner Guy Yeoman

  公开号：US20090118467A1

  公开（公告）日：2009-05-07

  The following invention is directed to macromolecules having controlled stoichiometry and topology, processes for their production, and applications for their use. The macromolecules have a controlled functional moiety stoichiometry and include at least one dendritic motif having a surface layer formed from at least one surface building unit and at least one subsurface layer formed from at least one building unit, the surface building unit and building units having a hydrocarbon backbone bearing a carbonyl group and at least one amine group; and at least two different functional moieties on the building unit and/or surface building unit; where functional moiety stoichiometry refers to the number and type of functional moieties.

  以下发明涉及具有可控化学计量和拓扑结构的高分子，其生产过程以及其使用的应用。这些高分子具有可控的功能基团化学计量，并包括至少一个树枝状基序，其表面层由至少一个表面构建单元形成，而至少一个次表面层由至少一个构建单元形成，表面构建单元和构建单元具有一个碳氢骨架，带有一个羰基基团和至少一个胺基团；以及构建单元和/或表面构建单元上至少两种不同的功能基团；其中功能基团化学计量指的是功能基团的数量和类型。
• MACROMOLECULAR COMPOUNDS HAVING CONTROLLED STOICHIOMETRY
  申请人：Krippner Guy Yeoman

  公开号：US20120302730A1

  公开（公告）日：2012-11-29

  The following invention is directed to macromolecules having controlled stoichiometry and topology, processes for their production, and applications for their use. The macromolecules have a controlled functional moiety stoichiometry and include at least one dendritic motif having a surface layer formed from at least one surface building unit and at least one subsurface layer formed from at least one building unit, the surface building unit and building units having a hydrocarbon backbone bearing a carbonyl group and at least one amine group; and at least two different functional moieties on the building unit and/or surface building unit; where functional moiety stoichiometry refers to the number and type of functional moieties.

  以下发明涉及具有控制的化学计量和拓扑结构的大分子，其生产过程以及其使用的应用。这些大分子具有受控的功能基团化学计量，并且包括至少一个树枝状基元，其表面层由至少一个表面构建单元形成，而至少一个亚表面层由至少一个构建单元形成，表面构建单元和构建单元具有带有羰基和至少一个胺基的碳氢骨架；以及在构建单元和/或表面构建单元上至少两种不同的功能基团；其中功能基团化学计量指的是功能基团的数量和类型。