propoxy-tert-butyl alcohol | 210579-29-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: propoxy-tert-butyl alcohol
• 英文别名: Propoxy-tert-butylalkohol；1-Propyloxy-2-methyl-propanol-(2)；2-Methyl-1-propoxypropan-2-ol
• CAS: 210579-29-6
• 化学式: C₇H₁₆O₂
• 分子量: 132.203
• InChiKey: JGJDFSSOMSPAAM-UHFFFAOYSA-N

物化性质

• 沸点：
  149.2-150.2 °C
• 密度：
  0.8708 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  propoxy-tert-butyl alcohol 在 氨 、 三乙胺 作用下， 以 二氯甲烷 、 异丙醇 为溶剂， 反应 54.0h， 生成 3-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 5-O-(2-methyl-1-propoxypropan-2-yl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  参考文献：
  名称：

  Asymmetric N-(3,3-diphenylpropyl)aminoalkyl esters of 4-aryl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acids with antihypertensive activity

  摘要：

  A series of asymmetric 4-aryl-1,4-dihydropyridine-3,5-dicarboxylates characterized by the presence of a 3,3-diphenyl-propylamino moiety in one of the ester groups were synthesized. They exhibited remarkable antihypertensive activity in spontaneously hypertensive rats as well as affinity for the 1,4-dihydropyridines binding site labelled by H-3-nitrendipine in the calcium channel. Introduction of this bulky and lipophilic amine confers to the whole series an elevated level of antihypertensive activity and a long duration of action, a structure-dependent modulation of the activity being found only in the subset characterized by the presence of a branched propylene bridge between the ester and the amino groups. The presence of the amino group is essential for oral activity. Out of this series, compound 9u (Rec 15/2375-lercanidipine) was selected for clinical development and obtained marketing authorization as an antihypertensive in several countries. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(98)80015-9
• 作为产物：
  描述：

  甲基碘化镁 、 propoxyacetic acid 生成 propoxy-tert-butyl alcohol
  参考文献：
  名称：

  Palomaa, Chemisches Zentralblatt, 1918, vol. 89, # I, p. 1144

  摘要：

  DOI：

文献信息

• MOLECULAR PRECURSOR COMPOUNDS FOR ZINC-GROUP 13 MIXED OXIDE MATERIALS
  申请人：Precursor Energetics, Inc.

  公开号：US20150218190A1

  公开（公告）日：2015-08-06

  Molecular precursor compounds, processes and compositions for making Zn-Group 13 mixed oxide materials including IZO, GZO, AZO and BZO, by providing inks comprising a molecular precursor compound having the formula M A a Zn(OROR) 3a+2 , and printing or depositing the inks on a substrate. The printed or deposited ink films can be treated to convert the molecular precursor compounds to a material.

  分子前体化合物、制备Zn-Group 13混合氧化物材料（包括IZO、GZO、AZO和BZO）的过程和组合物，方法是提供包含具有公式M的分子前体化合物的油墨，在基底上印刷或沉积这些油墨。印刷或沉积的油墨膜可以经处理转化为材料。
• EFFICIENT CATALYSIS OF HETEROPOLY ACID FOR ALCOHOLYSIS OF EPOXIDE
  作者：Yusuke Izumi、Kyoji Hayashi

  DOI：10.1246/cl.1980.787

  日期：1980.7.5

  Heteropoly acid (HPA) was found to catalyze the alcoholysis of epoxide more efficiently than the conventional acid catalysts such as sulfuric acid, perchloric acid and p-toluenesulfonic acid, at 45°C in the homogeneous liquid phase. The reason for the high catalytic activity of HPA is also discussed.

  研究发现，在45°C的均相液相中，杂多酸（HPA）催化环氧化物醇解的效率比传统的酸性催化剂如硫酸、高氯酸和甲苯磺酸更高。同时，也讨论了HPA高催化活性的原因。
• THIADIAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS
  申请人：Chen Li

  公开号：US20100152203A1

  公开（公告）日：2010-06-17

  Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R 1 is optionally substituted thiadiazolyl, and R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X 3 and/or a P2X 2/3 receptor antagonists and methods of making the compounds.

  式I的化合物：或其药用可接受的盐，其中，R1是可选择地取代的噻二唑基，R2、R3、R4、R5、R6、R7和R8如本文所定义。还揭示了使用这些化合物治疗与P2X3和/或P2X2/3受体拮抗剂相关的疾病的方法以及制备这些化合物的方法。
• Nitrogen containing heterocyclic compounds
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0170524A2

  公开（公告）日：1986-02-05

  Compounds of the formula (III): or salts or acyl derivatives thereof, for use as antifungal and antiprotozoal agents are disclosed. Compositions containing the compounds are also disclosed as are method for the preparation of the compounds and intermediates in their preparation.

  本研究公开了式 (III)： 或其盐或酰基衍生物，用作抗真菌剂和抗原虫剂。此外，还公开了含有这些化合物的组合物，以及这些化合物的制备方法和制备这些化合物的中间体。
• METHOD FOR PREPARING ORGANIC FLUORIDE-ALIPHATIC COMPOUND AND METHOD FOR PURIFYING ORGANIC FLUORIDE-ALIPHATIC COMPOUND
  申请人：The Asan Foundation

  公开号：EP3216780A1

  公开（公告）日：2017-09-13

  The present disclosure relates to a method for preparing a radiopharmaceutical and, specifically, to a method for preparing an organic fluoride-aliphatic compound usable as a radiopharmaceutical, to a method for purifying the prepared organic fluoride-aliphatic compound, and to a method for preparing a radiopharmaceutical by using a cassette comprising a backdraft preventing reaction container. According to the present disclosure, the organic fluoride-aliphatic compound can be prepared and purified through even a simple process at high yield, high efficiency, and high purity, and the radiopharmaceutical can be safely prepared without damage to a synthetic apparatus.

  本公开涉及一种制备放射性药物的方法，具体而言，涉及一种制备可用作放射性药物的有机氟脂肪族化合物的方法，涉及一种纯化所制备的有机氟脂肪族化合物的方法，还涉及一种通过使用由防逆流反应容器组成的盒制备放射性药物的方法。根据本公开内容，即使是简单的工艺，也可以高产率、高效率和高纯度地制备和纯化有机氟脂化合物，并且可以安全地制备放射性药物，而不会损坏合成装置。