4-Ethyl-5-pyridin-3-yl-2,4-dihydro[1,2,4]triazol-3-one | 1182358-50-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-Ethyl-5-pyridin-3-yl-2,4-dihydro[1,2,4]triazol-3-one
• 英文别名: 4-ethyl-3-pyridin-3-yl-1H-1,2,4-triazol-5-one
• CAS: 1182358-50-4
• 化学式: C₉H₁₀N₄O
• 分子量: 190.205
• InChiKey: ALBDLMGMFOOLFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-Ethyl-5-pyridin-3-yl-2,4-dihydro[1,2,4]triazol-3-one 、 环氧溴丙烷 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 、 oil 为溶剂， 反应 72.0h， 生成 4-Ethyl-2-oxiranylmethyl-5-pyridin-3-yl-2,4-dihydro[1,2,4]triazol-3-one
  参考文献：
  名称：

  BICYCLOAMINE DERIVATIVES

  摘要：

  由式(I)表示的化合物及其药学上可接受的盐具有出色的钠通道抑制作用，并可用作治疗剂和各种神经痛、神经病、癫痫、失眠、早泄等的镇痛剂。其中Q代表乙烯等，R1、R2和R3代表氢等，X1代表C1-6烷基等，X2代表C1-6烷基等，A1代表5-至6-成员杂环基团等，A2代表C6-14芳基等。

  公开号：

  US20090270369A1

文献信息

• [EN] BINARY COMPOSITIONS AS DISRUPTORS OF ORCO-MEDIATED ODORANT SENSING<br/>[FR] COMPOSITIONS BINAIRES UTILISÉES COMME PERTURBATEURS DE DÉTECTION DE SUBSTANCES ODORANTES DÉPENDANT DES RÉCEPTEURS ORCO
  申请人：UNIV VANDERBILT

  公开号：WO2016154471A1

  公开（公告）日：2016-09-29

  In one aspect, the invention relates to binary compositions that disrupt ORco- mediated odorant sensing. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting) functions in organisms that express ORco receptors such as airborne insects, e.g., mosquitos, and ticks. Method of employing such agents, and articles incorporating the same, are also provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  在某个方面，本发明涉及破坏ORco介导的气味感应的二元组合物。具体地，提供了可以抑制表达ORco受体的生物体（例如空气传播昆虫，如蚊子和蜱）的感觉（例如宿主定位）功能的化合物和组合物。还提供了使用这些药剂的方法和包含这些药剂的文章。本摘要旨在作为搜索特定领域的扫描工具，不限制本发明。
• BICYCLOAMINE DERIVATIVE
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP2241567A1

  公开（公告）日：2010-10-20

  Compounds represented by formula (I) and pharmaceutically acceptable salts thereof have excellent sodium channel inhibitory action and are useful as therapeutic agents and analgesics for various kinds of neuralgia, neuropathy, epilepsy, insomnia, premature ejaculation and the like. wherein Q represents ethylene, etc., R1, R2 and R3 represent hydrogen, etc., X1 represents C1-6 alkylene, etc., X2 represents C1-6 alkylene, etc., A1 represents a 5- to 6-membered heterocyclic group, etc., and A2 represents C6-14 aryl, etc.

  式 (I) 所代表的化合物及其药学上可接受的盐类具有出色的钠通道抑制作用，可用作各种神经痛、神经病、癫痫、失眠、早泄等疾病的治疗剂和镇痛剂。 其中 Q 代表乙烯等，R1、R2 和 R3 代表氢等，X1 代表 C1-6 亚烷基等，X2 代表 C1-6 亚烷基等，A1 代表 5 至 6 元杂环基团等，A2 代表 C6-14 芳基等。
• Binary compositions as disruptors of orco-mediated odorant sensing
  申请人：VANDERBILT UNIVERSITY

  公开号：US10791739B2

  公开（公告）日：2020-10-06

  In one aspect, the invention relates to binary compositions that disrupt ORco-mediated odorant sensing. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting) functions in organisms that express ORco receptors such as airborne insects, e.g., mosquitoes, and ticks. Method of employing such agents, and articles incorporating the same, are also provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  在一个方面，本发明涉及破坏 ORco 介导的气味感应的二元组合物。特别是，本发明提供的化合物和组合物可以抑制表达 ORco 受体的生物（如空气传播的昆虫，如蚊子和蜱虫）的感官（如宿主靶向）功能。此外，还提供了使用这些制剂的方法以及包含这些制剂的物品。本摘要旨在作为一种扫描工具，用于特定技术领域的搜索，而非对本发明的限制。
• BINARY COMPOSITIONS AS DISRUPTORS OF ORCO-MEDIATED ODORANT SENSING
  申请人：VANDERBILT UNIVERSITY

  公开号：US20180092359A1

  公开（公告）日：2018-04-05

  In one aspect, the invention relates to binary compositions that disrupt ORco-mediated odorant sensing. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting) functions in organisms that express ORco receptors such as airborne insects, e.g., mosquitoes, and ticks. Method of employing such agents, and articles incorporating the same, are also provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• US8252810B2
  申请人：——

  公开号：US8252810B2

  公开（公告）日：2012-08-28