Fumarsaeure-bis-dipropylamid | 5240-52-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Fumarsaeure-bis-dipropylamid
• 英文别名: N1,N1,N4,N4-tetrapropylfumaramide；(E)-N,N,N',N'-tetrapropylbut-2-enediamide
• CAS: 5240-52-8
• 化学式: C₁₆H₃₀N₂O₂
• 分子量: 282.426
• InChiKey: YEOXMHYGVBZSNS-MDZDMXLPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.84
• 重原子数：
  20.0
• 可旋转键数：
  10.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  40.62
• 氢给体数：
  0.0
• 氢受体数：
  2.0

安全信息

• 海关编码：
  2924199090

反应信息

• 作为反应物：
  描述：

  Fumarsaeure-bis-dipropylamid 在 potassium osmate(VI) dihydrate 、 sodium periodate 、 水 、 N-甲基吗啉氧化物 、 柠檬酸 作用下， 以 二氯甲烷 、 叔丁醇 为溶剂， 反应 92.0h， 生成
  参考文献：
  名称：

  Development of an organo- and enzyme-catalysed one-pot, sequential three-component reaction

  摘要：

  A one-pot, three-component process is described which involves both organo- and enzyme-catalysed carbon-carbon bond-forming steps. In the first step, an organocatalyst catalyses the aldol reaction between acetaldehyde and a glyoxylamide. After dilution with additional aqueous buffer, and addition of pyruvate and an aldolase enzyme variant, a second aldol reaction occurs to yield a final product. Crucially, it was possible to develop a reaction in which both the organo- and enzyme-catalysed reactions could be performed in the same aqueous buffer system. The reaction described is the first example of a one-pot, three-component reaction in which the two carbon-carbon bond-forming processes are catalysed using the combination of an organocatalyst and an enzyme. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.02.010
• 作为产物：
  描述：

  反丁烯二酰氯 、 二正丙胺 生成 Fumarsaeure-bis-dipropylamid
  参考文献：
  名称：

  Über alkylierte Amide bicyclischer Dicarbonsäuren, 4. Mitt.:

  摘要：

  DOI：

  10.1007/bf01185918

文献信息

• Thermally and Photochemically Induced Dethreading of Fumaramide-Based Kinetically Stable Pseudo[2]rotaxanes
  作者：Alberto Martinez-Cuezva、Fatima Morales、Grace R. Marley、Adrian Lopez-Lopez、Juan Carlos Martinez-Costa、Delia Bautista、Mateo Alajarin、Jose Berna

  DOI：10.1002/ejoc.201900073

  日期：2019.6.10

  The thermal‐ and light‐driven dethreading processes of kinetically stable pseudo[2]rotaxanes bearing tetrasubstituted‐fumaramides as threads are described. The influence of the stopper size, the flexibility of the thread and macrocycle and the strength of the intercomponent interactions on the disconnection rate have been thoroughly studied.

  描述了以四取代富马酰胺为线的动力学稳定的假[2]轮烷的热和光驱动脱线过程。彻底研究了塞子尺寸，螺纹和大环的柔韧性以及组分间相互作用的强度对断开速率的影响。
• Development of an organo- and enzyme-catalysed one-pot, sequential three-component reaction
  作者：Angela Kinnell、Thomas Harman、Matilda Bingham、Alan Berry、Adam Nelson

  DOI：10.1016/j.tet.2012.02.010

  日期：2012.9

  A one-pot, three-component process is described which involves both organo- and enzyme-catalysed carbon-carbon bond-forming steps. In the first step, an organocatalyst catalyses the aldol reaction between acetaldehyde and a glyoxylamide. After dilution with additional aqueous buffer, and addition of pyruvate and an aldolase enzyme variant, a second aldol reaction occurs to yield a final product. Crucially, it was possible to develop a reaction in which both the organo- and enzyme-catalysed reactions could be performed in the same aqueous buffer system. The reaction described is the first example of a one-pot, three-component reaction in which the two carbon-carbon bond-forming processes are catalysed using the combination of an organocatalyst and an enzyme. (C) 2012 Elsevier Ltd. All rights reserved.
• Über alkylierte Amide bicyclischer Dicarbonsäuren, 4. Mitt.:
  作者：H. Koch、J. Kotlan

  DOI：10.1007/bf01185918

  日期：1965.11