AgSCF3 Radical Addition Based on an Oxidant-Free α,β-Amide (Trifluoromethyl)sulfanylation Reaction
作者:Yang Li、Zhi-Bo Li、Jin Zhang、Yi-Ran Shi、Hong Li、Min-Ge Yang、Wen-Qing Zhu、Qiang-Wei Fan
DOI:10.1055/s-0043-1763759
日期:2024.12
(Trifluoromethyl)sulfanylamides are an important class of organic compounds that are common among natural products and drug molecules. Here, we report a (trifluoromethyl)sulfanylation reaction using silver(I) (trifluoromethyl)sulfide as a free-radical (trifluoromethyl)sulfanylation reagent for β-amide compounds. This reaction does not require stoichiometric oxidants or additional transition-metal catalysts