5-(3-hydroxypropoxy)-N-methylpyridine-2-carboxamide | 896423-16-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-(3-hydroxypropoxy)-N-methylpyridine-2-carboxamide
• CAS: 896423-16-8
• 化学式: C₁₀H₁₄N₂O₃
• 分子量: 210.233
• InChiKey: YNCKSVGWBWGMFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  71.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-(3-hydroxypropoxy)-N-methylpyridine-2-carboxamide 在 四溴化碳 、 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 以69 %的产率得到5-(3-bromopropoxy)-N-methylpicolinamide
  参考文献：
  名称：

  [EN] PHARMACEUTICAL COMPOUND
  [FR] COMPOSÉ PHARMACEUTIQUE

  摘要：

  A compound comprising the following formula: wherein R1 is selected from H and a substituted or unsubstituted organic group; R2 may be present or absent and is independently selected from H and a substituted or unsubstituted organic group; R1 and R2 may together form a ring; R3 is independently selected from H and a substituted or unsubstituted organic group; R6 may be present or absent and is independently selected from H and a substituted or unsubstituted organic group; Z1 and Z2 are independently selected from C and N; and L comprises an organic group as defined herein.

  公开号：

  WO2023156386A2
• 作为产物：
  描述：

  5-羟基-2-吡啶羧酸 在 HATU 、 caesium carbonate 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 19.0h， 生成 5-(3-hydroxypropoxy)-N-methylpyridine-2-carboxamide
  参考文献：
  名称：

  [EN] PHARMACEUTICAL COMPOUND
  [FR] COMPOSÉ PHARMACEUTIQUE

  摘要：

  A compound comprising the following formula: wherein R1 is selected from H and a substituted or unsubstituted organic group; R2 may be present or absent and is independently selected from H and a substituted or unsubstituted organic group; R1 and R2 may together form a ring; R3 is independently selected from H and a substituted or unsubstituted organic group; R6 may be present or absent and is independently selected from H and a substituted or unsubstituted organic group; Z1 and Z2 are independently selected from C and N; and L comprises an organic group as defined herein.

  公开号：

  WO2023156386A2

文献信息

• CERTAIN THIENOPYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS
  申请人：Liu Ruiping

  公开号：US20100010017A1

  公开（公告）日：2010-01-14

  Certain thienopyrimidine derivatives are useful for the inhibition of PDE10 enzymes, and thus are useful for treating psychiatric or neurological syndromes, e.g., psychoses, obsessive-compulsive disorder and/or Parkinson's disease, as well as, for example, treating a disease state modulated by PDE10 activity.

  某些噻唑嘧啶衍生物可用于抑制PDE10酶，因此可用于治疗精神病或神经系统综合症，例如精神病、强迫症和/或帕金森病，以及治疗受PDE10活性调节的疾病状态。
• Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors
  申请人：Liu Ruiping

  公开号：US20070259896A1

  公开（公告）日：2007-11-08

  Certain thienopyrimidine derivatives are useful for the inhibition of PDE10 enzymes, and thus are useful for treating psychiatric or neurological syndromes, e.g., pyschoses, obsessive-compulsive disorder and/or Parkinson's disease, as well as, for example, treating a disease state modulated by PDE10 activity.

  某些噻唑嘧啶衍生物可用于抑制PDE10酶的活性，因此可用于治疗精神或神经症候群，例如精神病、强迫症和/或帕金森病，以及治疗受PDE10活性调节的疾病状态。
• WO2006/71988
  申请人：——

  公开号：——

  公开（公告）日：——
• THIENOPYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS
  申请人：Memory Pharmaceutical Corporation

  公开号：EP1831229A1

  公开（公告）日：2007-09-12
• US7576080B2
  申请人：——

  公开号：US7576080B2

  公开（公告）日：2009-08-18