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1,5-methano-7-methoxy-2,3,4,5-tetrahydro-1H-2-benzazepine | 24467-90-1

中文名称
——
中文别名
——
英文名称
1,5-methano-7-methoxy-2,3,4,5-tetrahydro-1H-2-benzazepine
英文别名
4-methoxy-9-aza-tricyclo[6.3.1.0(2.7)]dodeca-2,4,6-triene;1,5-Methano-7-methoxy-2,3,4,5-tetrahydro-1H-2-benzazepin;4-Methoxy-9-aza-tricyclo[6.3.1.0*2,7*]dodeca-2,4,6-triene;4-methoxy-9-azatricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene
1,5-methano-7-methoxy-2,3,4,5-tetrahydro-1H-2-benzazepine化学式
CAS
24467-90-1
化学式
C12H15NO
mdl
——
分子量
189.257
InChiKey
MWMITLKZUPSAQS-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    1.6
  • 重原子数:
    14
  • 可旋转键数:
    1
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.5
  • 拓扑面积:
    21.3
  • 氢给体数:
    1
  • 氢受体数:
    2

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量
  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

点击查看最新优质反应信息

文献信息

  • Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
    申请人:Peters Stefan
    公开号:US20110269791A1
    公开(公告)日:2011-11-03
    The present invention relates to compounds defined by Formula (I), wherein the groups A, B, X, m, n and o are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity and dyslipidemia.
    本发明涉及由式(I)定义的化合物,其中A、B、X、m、n和o基团的定义如权利要求1中所述,具有有价值的药理活性。特别是这些化合物是11β-羟基类固醇脱氢酶(HSD)1的抑制剂,因此适用于治疗和预防可以受到该酶抑制影响的疾病,如代谢性疾病,特别是2型糖尿病、肥胖症和血脂异常。
  • Aryl-and Heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
    申请人:Himmelsbach Frank
    公开号:US20110190262A1
    公开(公告)日:2011-08-04
    The present invention relates to compounds defined by formula I wherein the groups R 1 to R 3 , X, m, n and o are defined as in claim 1 , possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity and dyslipidemia.
    本发明涉及公式I所定义的化合物,其中R1至R3、X、m、n和o的定义如权利要求书中所述,具有有价值的药理活性。特别地,这些化合物是11β-羟基类固醇脱氢酶(HSD)1的抑制剂,因此适用于治疗和预防可以通过抑制该酶而受影响的疾病,如代谢性疾病,特别是2型糖尿病、肥胖症和血脂异常。
  • Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
    申请人:Himmelsbach Frank
    公开号:US08859580B2
    公开(公告)日:2014-10-14
    The present invention relates to compounds defined by formula I wherein the groups R1 to R3, X, m, n and o are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity and dyslipidemia.
    本发明涉及公式I定义的化合物,其中R1至R3、X、m、n和o组的定义如权利要求书中所述,具有有价值的药理活性。特别地,这些化合物是11β-羟基类固醇脱氢酶(HSD)1的抑制剂,因此适用于治疗和预防可以受到该酶抑制影响的疾病,例如代谢性疾病,特别是2型糖尿病、肥胖症和血脂异常。
  • Urea derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
    申请人:Eckhardt Matthias
    公开号:US20110028445A1
    公开(公告)日:2011-02-03
    The present invention relates to compounds defined by formula (I) wherein the groups A, B, X, m, n and o are defined as in claim 1 , possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11 β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity and dyslipidemia.
    本发明涉及由式(I)定义的化合物,其中A,B,X,m,n和o的基团如权利要求1中所定义,具有有价值的药理活性。特别地,这些化合物是11β-羟基类固醇脱氢酶(HSD)1的抑制剂,因此适用于治疗和预防可以通过抑制该酶而受到影响的疾病,如代谢性疾病,特别是2型糖尿病,肥胖症和血脂异常。
  • Benzazabicyclic carbamates as cholinesterase inhibitors
    申请人:PFIZER INC.
    公开号:EP0415634A2
    公开(公告)日:1991-03-06
    Compounds of the formula I are cholinesterase inhibitors useful in enhancing memory.
    式 I 的化合物 是有助于增强记忆力的胆碱酯酶抑制剂。
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