ethyl methallyoxyacetate | 22874-89-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl methallyoxyacetate
• 英文别名: ethyl 2-((2-methylallyl)oxy)acetate；Glycolsaeureaethylester-methallylaether；Ethyl 2-methallyloxyacetat；Ethyl 2-(2-methylprop-2-enoxy)acetate
• CAS: 22874-89-1
• 化学式: C₈H₁₄O₃
• 分子量: 158.197
• InChiKey: WPWIKXRPCYWNRC-UHFFFAOYSA-N

物化性质

• 沸点：
  205.2±15.0 °C(Predicted)
• 密度：
  0.956±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl methallyoxyacetate 在 sodium hydroxide 、 水 、 盐酸 作用下， 以 乙醇 、 水 为溶剂， 生成 (2-甲基烯丙氧基)-乙酸
  参考文献：
  名称：

  烯烃的布朗斯台德碱调节区选择性Pd催化的分子内有氧氧化胺化：七元酰胺的形成和烯丙基CH活化的证据

  摘要：

  已经开发了一种新型的钯催化的烯烃分子内需氧氧化烯丙基CH胺化反应。布朗斯台德碱可以调节区域选择性，有利于7元环的形成。使用氘标记的底物作为探针的机理研究支持决定速率的烯丙基CH活化/不可逆还原消除途径。

  DOI：

  10.1021/ol900941t
• 作为产物：
  描述：

  乙醇酸乙酯 、 3-氯-2-甲基丙烯 在 sodium hydride 作用下， 生成 ethyl methallyoxyacetate
  参考文献：
  名称：

  Hydroxynitrile lyase catalyzed enantioselective HCN addition to O-protected α-hydroxyaldehydes

  摘要：

  Various O-protected glycol- and racemic lactaldehydes 3 and 6 as well as O-allyl protected racemic alpha-hydroxyaldehydes 7 (R-1=Et Pr, Bu) have been prepared to investigate and perform a stereoselective Kiliani-Fischer synthesis by hydroxynitrile lyase (HNL) catalyzed addition of HCN. From all protecting groups investigated the allyl moiety was most suitable. (R)-PaHNL from bitter almonds (Prunus amygdalus), yielding the (2S)-cyanohydrins 8-10, was found to be a more stereoselective catalyst than (S)-MeHNL from maniok (Manihot esculenta). While (R)-PaHNL led to enantiomeric excesses greater than or equal to 93%, with (S)-MeHNL the (2R)-cyanohydrins 8-10 were obtained with enantiomeric excesses less than or equal to 78%. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(99)00275-x

文献信息

• [EN] CERTAIN CHEMICAL COMPOSITIONS AND METHODS OF USE THEREOF<br/>[FR] COMPOSITIONS CHIMIQUES PARTICULIÈRES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：ALGEN BIOTECHNOLOGIES INC

  公开号：WO2021231892A1

  公开（公告）日：2021-11-18

  The present disclosure provides CDK9 inhibitors. Also provided are methods of treating a disease or a disorder comprising administering to a subject in need of treatment one of the CDK9 inhibitors disclosed herein. In some embodiments, the disease or disorder to be treated is cancer. In some embodiments, the disease or disorder is liver cancer.

  本公开提供了CDK9抑制剂。还提供了治疗疾病或紊乱的方法，包括向需要治疗的受试者施用本公开的CDK9抑制剂之一。在某些实施例中，要治疗的疾病或紊乱是癌症。在某些实施例中，疾病或紊乱是肝癌。
• Photolysis of diazocarbonyl compounds in allylic alcohols: new preparation of bicyclic lactones
  作者：Wataru Ando、Isamu Imai、Toshihiko Migita

  DOI：10.1039/c39720000822

  日期：——

  Photolysis of dimethyl diazomalonate and ethyl diazoacetate in allylic alcohols gives the O–H insertion products of the carbene together with bicyclolactones; sensitized photolysis gives only bicyclolactones.

  重氮丙二酸二甲酯和重氮乙酸乙酯在烯丙基醇中的光解作用可得到卡宾的O–H插入产物以及双环内酯。敏化光解仅产生双环内酯。
• Activated ester monomers, polymers formed therefrom and coating compositions containing said polymers
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0020000A1

  公开（公告）日：1980-12-10

  Ethylenically unsaturated monomers containing activated ester groups are used to make polymers and copolymers which are useful in coatings, adhesives and moldings. The monomers have the formula: wherein A is an organic group containing a polymerizable vinyl linkage; Z is selected from O or S; m and n are integers each selected from 0 and 1. Y is a bridging unit, X is selected from the group consisting essentially of wherein R' is an alkyl group with 1-8 carbon atoms: and R is an aliphatic moiety.

  含有活化酯基的乙烯基不饱和单体可用于制造聚合物和共聚物，这些聚合物和共聚物可用于涂料、粘合剂和模塑。这些单体的化学式如下 其中 A 是含有可聚合乙烯基连接的有机基团；Z 选自 O 或 S；m 和 n 分别是选自 0 和 1 的整数；Y 是桥接单元、 X 主要选自以下组成的组 其中 R' 是含有 1-8 个碳原子的烷基：R 是脂肪族分子。
• Copolymers formed from activated ester monomers, and coating compositions containing said copolymers
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0049910A2

  公开（公告）日：1982-04-21

  There are provided copolymers of (I) a compound of the - formula: wherein A is an organic group containing a polymerizable vinyl linkage; Z is selected from O or S; m and n are integers each selected from 0 and 1, Y is a bridging unit; X is selected from the group consisting essentially of wherein R' is an alkyl group with 1-8 carbon atoms, and R is an aliphatic moiety; and (II) one or more copolymerizable vinyl monomers. The copolymers may be incorporated into curable coating compositions with compounds containing at least two primary or secondary amine groups per molecule.

  提供了(I)式化合物的共聚物： 其中 A 是含有可聚合乙烯基连接的有机基团；Z 选自 O 或 S；m 和 n 分别是选自 0 和 1 的整数；Y 是桥接单元；X 选自基本上由以下各项组成的组 其中 R' 是含有 1-8 个碳原子的烷基，R 是脂肪族分子；以及 (II) 一种或多种可共聚的乙烯基单体。共聚物可与每个分子至少含有两个伯胺或仲胺基团的化合物一起掺入可固化的涂料组合物中。
• Photolysis of diazocarbonyl compounds in allylic alcohols. New preparation of bicyclo[3,1,0]lactones and the nature of the reactive intermediate
  作者：Wataru Ando、Isamu Imai、Toshihiko Migita

  DOI：10.1021/jo00796a006

  日期：1972.11