DL-3,5-Diiod-3'-methyl-thyronin | 4080-14-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: DL-3,5-Diiod-3'-methyl-thyronin
• 英文别名: 3,5-Diiod-3'-methyl-thyronin；2-Azaniumyl-3-[4-(4-hydroxy-3-methylphenoxy)-3,5-diiodophenyl]propanoate
• CAS: 4080-14-2
• 化学式: C₁₆H₁₅I₂NO₄
• 分子量: 539.108
• InChiKey: HYJPABWHKVJCIP-UHFFFAOYSA-N

物化性质

• 沸点：
  561.3±50.0 °C(Predicted)
• 密度：
  2.020±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  92.8
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  在 氢碘酸 、 铜 、 溶剂黄146 、 三乙胺 作用下， 以 甲醇 为溶剂， 生成 DL-3,5-Diiod-3'-methyl-thyronin
  参考文献：
  名称：

  甲状腺激素药。I.一些3'和3'，5'-烷基和ARYL-3,5-二碘代酪氨酸的合成和低胆固醇活性。

  摘要：

  DOI：

  10.1021/jm00341a020

文献信息

• Compounds and methods for inhibiting Cif virulence factor
  申请人：Trustees of Dartmouth College

  公开号：US10322118B2

  公开（公告）日：2019-06-18

  The present invention provides a screening assay for identifying inhibitors of Pseudomonas aeruginosa CFTR Inhibitory Factor as well as compositions and methods for ameliorating or treating a respiratory disease such as cystic fibrosis or secondary infection thereof.

  本发明提供了一种用于鉴定铜绿假单胞菌 CFTR 抑制因子抑制剂的筛选试验，以及用于改善或治疗呼吸道疾病（如囊性纤维化）或继发感染的组合物和方法。
• Process for the preparation of a sulfated derivative of 3,5-diiodo-o-[3-iodophenyl]-l-tyrosine
  申请人：BRACCO IMAGING S.p.A.

  公开号：US10457635B2

  公开（公告）日：2019-10-29

  The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-O-[3-iodo-4-(sulphooxy)phenyl]-L-tyrosine (T3S) by starting from the corresponding phenolic compound, in the presence of chlorosulfonic acid and dimethylacetamide as a solvent. The so obtained T3S compound may conveniently be isolated in a pure form as a solid in good yields. The present invention further relates to the process for T3S preparation, wherein the starting reagent is T2 and further comprising the formulation of such compound in tablets. Furthermore, the invention discloses non-radioactive immunoassays based on T3S derivatives.

  本发明涉及一种以相应的酚类化合物为起点，在氯磺酸和二甲基乙酰胺作为溶剂的存在下，制备衍生物 3,5-二碘-O-[3-碘-4-(磺氧基)苯基]-L-酪氨酸（T3S）的单钠盐的工艺。这样得到的 T3S 化合物可以很方便地以纯固体形式分离出来，收率很高。 本发明进一步涉及 T3S 的制备过程，其中起始试剂为 T2，并进一步包括将这种化合物制成片剂。 此外，本发明还公开了基于 T3S 衍生物的非放射性免疫测定。
• Process For The Preparation Of A Sulfated Derivative Of 3,5-Diiodo-O-[3-Iodophenyl]-L-Tyrosine
  申请人：BRACCO IMAGING S.p.A.

  公开号：US20180118669A1

  公开（公告）日：2018-05-03

  The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-O-[3-iodo-4-(sulphooxy)phenyl]-L-tyrosine (T3S) by starting from the corresponding phenolic compound, in the presence of chlorosulfonic acid and dimethylacetamide as a solvent. The so obtained T3S compound may conveniently be isolated in a pure form as a solid in good yields. The present invention further relates to the process for T3S preparation, wherein the starting reagent is T2 and further comprising the formulation of such compound in tablets. Furthermore, the invention discloses non-radioactive immunoassays based on T3S derivatives.
• Thyromimetics. I. The Synthesis and Hypocholesteremic Activity of Some 3' and 3',5'-Alkyl and Aryl-3,5-diiodothyronines
  作者：Benjamin Blank、Francis R. Pfeiffer、Cyrus M. Greenberg、James F. Kerwin

  DOI：10.1021/jm00341a020

  日期：1963.9