1-(naphthalen-2-yl)hexan-1-one | 17424-46-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(naphthalen-2-yl)hexan-1-one
• 英文别名: 1-(2-naphthyl)hexanone；1-[2]naphthyl-hexan-1-one；1-[2]Naphthyl-hexan-1-on；Amyl-ss-naphthylketon；1-naphthalen-2-ylhexan-1-one
• CAS: 17424-46-3
• 化学式: C₁₆H₁₈O
• 分子量: 226.318
• InChiKey: SSYVOIOUTSJIRY-UHFFFAOYSA-N

物化性质

• 熔点：
  68 °C(Solv: ethanol (64-17-5))
• 沸点：
  201-203 °C(Press: 12 Torr)
• 密度：
  1.023±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(naphthalen-2-yl)hexan-1-one 在 乙醚 、 copper(II) sulfate 作用下， 生成 2-(1-pentyl-heptyl)-naphthalene
  参考文献：
  名称：

  233.高分子量烃的合成。第一部分单烷基萘

  摘要：

  DOI：

  10.1039/jr9510001055
• 作为产物：
  描述：

  正戊基溴化镁 在 [RuCl2(benzene)]2 、 (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl (1R,2R)-1,2-二苯基乙二胺 、 potassium tert-butylate 、 环己酮 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 20.0h， 生成 1-(naphthalen-2-yl)hexan-1-one
  参考文献：
  名称：

  A catalytic deracemisation of alcohols

  摘要：

  使用一步氧化/还原方法，已成功将外消旋醇转化为最高可达99%对映体过量（ee）的手性富集醇。

  DOI：

  10.1039/b704956k

文献信息

• SMALL MOLECULE CMKLR1 ANTAGONISTS IN INFLAMMATORY DISEASE
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US20200345661A1

  公开（公告）日：2020-11-05

  α-NETA analogs are provided for the treatment of inflammatory disease.

  α-NETA类似物用于治疗炎症性疾病。
• Asymmetric Aldol Reaction of Alkenyl Esters with α-Keto Esters Catalyzed by Chiral Tin Alkoxides
  作者：Akira Yanagisawa、Chika Uchiyama、Kotaro Takagi

  DOI：10.1055/a-1665-9014

  日期：2021.12

  A catalytic enantioselective aldol reaction of alkenyl esters with α-keto esters was achieved by using an (R)-BINOL-derived chiral tin dibromide possessing 4-t-butylphenyl groups at the 3- and 3′-positions as a chiral precatalyst in the presence of sodium methoxide and methanol. Optically active aldol products possessing a chiral tertiary carbon were diastereoselectively obtained with up to 92% ee

  通过使用 (R)-BINOL 衍生的手性二溴化锡在 3-和 3'-位具有 4-叔丁基苯基作为手性预催化剂，实现了烯基酯与 α-酮酯的催化对映选择性羟醛反应。甲醇钠和甲醇的存在。具有手性叔碳的光学活性羟醛产物以非对映选择性获得，ee 高达 92%，产率中等至高，不仅来自环状烯基酯，而且在原位生成的手性甲醇锡的影响下也来自非环状酯。
• The preparation of 1,4-dicarbonyl compounds by photoreaction of ketones in the presence of oxidants
  作者：Michiharu Mitani、Mamoru Tamada、Shin-ichi Uehara、Kikuhiko Koyama

  DOI：10.1016/s0040-4039(01)81295-8

  日期：——

  Phenyl alkyl ketones were photo-irradiated in the presence of Cr(VI) or Mn(VII) oxidants to yield 1,4-dicarbonyl compounds regiospecifically while 2-octanone gave a regioisomeric mixture of 2,5-, 2,6-, and 2,7-octadiones.

  在Cr（VI）或Mn（VII）氧化剂存在下，对苯烷基酮进行光照射，以产生区域特异性的1,4-二羰基化合物，而2-辛酮则生成2,5,2,6-和6,5,5-三氯乙烷的区域异构体混合物。 2,7-辛二酮。
• Treatment of depression
  申请人：U.S. Philips Corporation

  公开号：US03937841A1

  公开（公告）日：1976-02-10

  The invention relates to new compounds of formula I ##SPC1## and salts thereof with pharmaceutically acceptable acids, in which formula all the substituents may be hydrogen, while R.sub.1 and R.sub.2 may furthermore be a methyl group, R.sub.3 an alkyl group, an alkoxy-alkylene group, an alkylthioalkylene group, an alkylsulphoxyalkylene group or an alkylsulphonalkylene group having up to 8 carbon atoms or a benzyl group, and R.sub.4, R.sub.5 and R.sub.6 a halogen atom, an alkyl group, an alkoxy group or an alkylthio group having up to 6 carbon atoms, a benzyloxy group, --OH, --NH.sub.2, a mono- or dialkylamino group, in which the alkyl group(s) contain(s) 1 or 2 carbon atoms, --CN or --CF.sub.3, and two of the substituents R.sub.4, R.sub.5 and R.sub.6 may each represent a metanitro group or together a trimethylene group, a tetramethylene group, a methylene dioxy group, an ethylene dioxy group, a benzo group, a pyridino group, an indeno-1,2-, a 1,4-benzthiazino-2,3 group or a 1,4-benzoxthiino-2,3 group, with the exception of the HCl salt of the compound in which R.sub.5 and R.sub.6 each represent an orthochlorine atom and R.sub. 1, R.sub.2, R.sub.3 and R.sub.4 each represent hydrogen.

  该发明涉及化学式I的新化合物及其与药学上可接受的酸盐，其中化合物中的所有取代基可能是氢，而R.sub.1和R.sub.2还可能是甲基基团，R.sub.3是烷基基团、烷氧基-烷基基团、烷基硫基-烷基基团、烷基磺氧基-烷基基团或烷基磺酸基-烷基基团，碳原子数最多为8，或苄基基团，R.sub.4、R.sub.5和R.sub.6是卤素原子、烷基基团、烷氧基或烷基硫基，碳原子数最多为6，苄氧基，-OH，-NH.sub.2，一元或二元烷基胺基团，其中烷基基团包含1或2个碳原子，-CN或-CF.sub.3，其中取代基R.sub.4、R.sub.5和R.sub.6中的两个可以分别表示一个甲基硝基基团，或者一起表示一个三亚甲基基团、四亚甲基基团、亚甲二氧基基团、乙烯二氧基基团、苯基团、吡啶基团、茚-1,2-基团、1,4-苯并噻吩-2,3基团或1,4-苯并噻吩-2,3基团，除了化合物的HCl盐，其中R.sub.5和R.sub.6各代表一个邻氯原子，而R.sub.1、R.sub.2、R.sub.3和R.sub.4各代表氢。
• Effects of IrO₂/Pt Hybrid Electrodes on the Crystallization and Ferroelectric Performances of Sol-gel-derived Pb(Zr,Ti)O₃ Thin Film Capacitors
  作者：Seung-Hyun Kim、Dong-Yeon Park、Hyun-Jung Woo、Dong-Soo Lee、Jowoong Ha、Cheol Song Hwang

  DOI：10.1557/jmr.2002.0257

  日期：2002.7

  The effects of IrO₂/Pt layered hybrid bottom and/or top electrode structures on the leakage current density versus voltage (J–V), polarization versus voltage (P–V), ferroelectric imprint, and fatigue properties of chemical-solution-derived Pb(Zr_xTi_1−x)O₃ (PZT, Zr/Ti = 35/65) thin films were investigated. The best P–V and J–V performances were obtained from a capacitor with nonhybrid electrodes (Pt/PZT/Pt capacitor). However, the poor fatigue performance of the capacitor required the adoption of hybrid electrode structures. A thin IrO₂ layer, as thin as 6 nm, which was inserted between top Pt electrode and PZT layer was sufficient for improving the fatigue performance without any degradation of the other ferroelectric properties. However, the same layer adopted on the bottom Pt electrode was not effective in improving the fatigue performance with degradation in P–V and J–V properties. This was ascribed to IrO₂ layer dissolution into the PZT layer during the crystallization annealing of the PZT thin film. A thicker IrO₂ layer resulted in more serious degradation.

  研究了 IrO2/Pt 层状混合底部和/或顶部电极结构对化学溶液衍生 Pb(ZrxTi1-x)O3 (PZT, Zr/Ti = 35/65)薄膜的漏电流密度随电压变化（J-V）、极化随电压变化（P-V）、铁电印记和疲劳特性的影响。非混合电极电容器（Pt/PZT/Pt 电容器）的 P-V 和 J-V 性能最佳。然而，由于电容器的疲劳性能较差，因此需要采用混合电极结构。在顶部铂电极和 PZT 层之间插入薄至 6 nm 的 IrO2 层足以改善疲劳性能，而不会降低其他铁电特性。然而，在底部铂电极上采用相同的层却不能有效改善疲劳性能，P-V 和 J-V 性能下降。这是因为在 PZT 薄膜的结晶退火过程中，IrO2 层溶解到了 PZT 层中。更厚的二氧化钛层会导致更严重的退化。