(5R)-5-(2,2-dimethoxyethyl)-6-methyl-7-phenylmethoxyheptan-2-ol | 195324-74-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (5R)-5-(2,2-dimethoxyethyl)-6-methyl-7-phenylmethoxyheptan-2-ol
• CAS: 195324-74-4
• 化学式: C₁₉H₃₂O₄
• 分子量: 324.461
• InChiKey: MXNACQPSEHJDMU-LEOMRAHMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (5R)-5-(2,2-dimethoxyethyl)-6-methyl-7-phenylmethoxyheptan-2-ol 在 吡啶 、 盐酸 、 potassium tert-butylate 作用下， 以 丙酮 、 叔丁醇 为溶剂， 生成 (3R)-3-(1-phenylmethoxypropan-2-yl)hept-6-enal
  参考文献：
  名称：

  Total synthesis of (+)-ligudentatol via Photoaddition-Fragmentation-Aromatic Annulation sequence

  摘要：

  First synthesis of the naturally occurring compound (+)-ligudentatol is presented. It demonstrates the synthetic utility of the ''Photoaddition-Fragmentation-Aromatic Annulation'' sequence, recently developed via the intramolecular photocycloaddition of dihydropyrones to alkenes. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)21374-2
• 作为产物：
  描述：

  (R)-(+)-7,7-dimethoxy-5-(1-methylethenyl)-2-heptanone 在 9-borabicyclo[3.3.1]nonane dimer 、 双氧水 、 sodium hydride 作用下， 生成 (5R)-5-(2,2-dimethoxyethyl)-6-methyl-7-phenylmethoxyheptan-2-ol
  参考文献：
  名称：

  Total synthesis of (+)-ligudentatol via Photoaddition-Fragmentation-Aromatic Annulation sequence

  摘要：

  First synthesis of the naturally occurring compound (+)-ligudentatol is presented. It demonstrates the synthetic utility of the ''Photoaddition-Fragmentation-Aromatic Annulation'' sequence, recently developed via the intramolecular photocycloaddition of dihydropyrones to alkenes. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)21374-2

文献信息

• Total synthesis of (+)-ligudentatol via Photoaddition-Fragmentation-Aromatic Annulation sequence
  作者：Nizar Haddad、Husein Salman

  DOI：10.1016/s0040-4039(97)21374-2

  日期：1997.8

  First synthesis of the naturally occurring compound (+)-ligudentatol is presented. It demonstrates the synthetic utility of the ''Photoaddition-Fragmentation-Aromatic Annulation'' sequence, recently developed via the intramolecular photocycloaddition of dihydropyrones to alkenes. (C) 1997 Elsevier Science Ltd.