(S)-methyl-2-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)propanoate | 1447710-87-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-methyl-2-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)propanoate
• 英文别名: methyl (2S)-2-[[5-[3-[4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl]pentan-3-yl]-1-methylpyrrole-2-carbonyl]amino]propanoate
• CAS: 1447710-87-3
• 化学式: C₂₈H₄₀N₂O₅
• 分子量: 484.636
• InChiKey: ZPEPCBSEFDBYHQ-IBGZPJMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  35
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  86.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (S)-methyl-2-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)propanoate 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 0.5h， 以95%的产率得到(S)-5-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)pentan-3-yl)-N-(1-hydroxypropan-2-yl)-1-methylpyrrole-2-carboxamide
  参考文献：
  名称：

  Novel nonsecosteroidal VDR agonists with phenyl-pyrrolyl pentane skeleton

  摘要：

  In order to find the vitamin D receptor (VDR) ligand whose VDR agonistic activity is separated from the calcemic activity sufficiently, novel nonsecosteroidal analogs with phenyl pyrrolyl pentane skeleton were synthesized and evaluated for the VDR binding affinity, antiproliferative activity in vitro and serum calcium raising ability in vivo (tacalcitol used as control). Among them, several compounds showed varying degrees of VDR agonistic and growth inhibition activities of the tested cell lines. The most effective compound 2g (EC50: 1.06 nM) exhibited stronger VDR agonistic activity than tacalcitol (EC50: 7.05 nM), inhibited the proliferations of HaCaT and MCF-7 cells with IC50 of 2.06 mu M and 0.307 mu M (tacalcitol: 2.07 mu M and 0.057 mu M) and showed no significant effect on serum calcium. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.09.015
• 作为产物：
  描述：

  4-羟基-3-甲基苯甲酸 在 硫酸 、 palladium on activated charcoal 、 三氟化硼乙醚 、 水 、 甲酸铵 、 sodium hydride 、 potassium carbonate 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 、 potassium iodide 、 potassium hydroxide 作用下， 以 甲醇 、 乙醚 、 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 反应 34.5h， 生成 (S)-methyl-2-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)propanoate
  参考文献：
  名称：

  Novel nonsecosteroidal VDR agonists with phenyl-pyrrolyl pentane skeleton

  摘要：

  In order to find the vitamin D receptor (VDR) ligand whose VDR agonistic activity is separated from the calcemic activity sufficiently, novel nonsecosteroidal analogs with phenyl pyrrolyl pentane skeleton were synthesized and evaluated for the VDR binding affinity, antiproliferative activity in vitro and serum calcium raising ability in vivo (tacalcitol used as control). Among them, several compounds showed varying degrees of VDR agonistic and growth inhibition activities of the tested cell lines. The most effective compound 2g (EC50: 1.06 nM) exhibited stronger VDR agonistic activity than tacalcitol (EC50: 7.05 nM), inhibited the proliferations of HaCaT and MCF-7 cells with IC50 of 2.06 mu M and 0.307 mu M (tacalcitol: 2.07 mu M and 0.057 mu M) and showed no significant effect on serum calcium. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.09.015

文献信息

• Novel nonsecosteroidal VDR agonists with phenyl-pyrrolyl pentane skeleton
  作者：Wei Shen、Jingwei Xue、Zekai Zhao、Can Zhang

  DOI：10.1016/j.ejmech.2013.09.015

  日期：2013.11

  In order to find the vitamin D receptor (VDR) ligand whose VDR agonistic activity is separated from the calcemic activity sufficiently, novel nonsecosteroidal analogs with phenyl pyrrolyl pentane skeleton were synthesized and evaluated for the VDR binding affinity, antiproliferative activity in vitro and serum calcium raising ability in vivo (tacalcitol used as control). Among them, several compounds showed varying degrees of VDR agonistic and growth inhibition activities of the tested cell lines. The most effective compound 2g (EC50: 1.06 nM) exhibited stronger VDR agonistic activity than tacalcitol (EC50: 7.05 nM), inhibited the proliferations of HaCaT and MCF-7 cells with IC50 of 2.06 mu M and 0.307 mu M (tacalcitol: 2.07 mu M and 0.057 mu M) and showed no significant effect on serum calcium. (C) 2013 Elsevier Masson SAS. All rights reserved.