N-propionyl-ε-caprolactam | 5515-03-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: N-propionyl-ε-caprolactam
• 英文别名: 1-propionyl-azepan-2-one；N-Propionylhomopiperidon-(2)；1-Propanoylazepan-2-one
• CAS: 5515-03-7
• 化学式: C₉H₁₅NO₂
• 分子量: 169.224
• InChiKey: VGTSJKBOTYPCLW-UHFFFAOYSA-N

物化性质

• 沸点：
  292.7±9.0 °C(Predicted)
• 密度：
  1.0755 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2933790090

反应信息

• 作为产物：
  描述：

  2-乙氧基-4,5,6,7-四氢-3H-氮杂卓 、 一氧化碳 在 dicobalt octacarbonyl 作用下， 以 乙二醇二甲醚 为溶剂， 100.0 ℃ 、6.89 MPa 条件下， 反应 48.0h， 以85%的产率得到N-propionyl-ε-caprolactam
  参考文献：
  名称：

  Toward Transition Metal-Catalyzed Carbonylation of Methanol without HI as Copromoter:  Catalytic Exocyclic Carbonylation of Cycloimino Esters

  摘要：

  Initial studies of a rare exocyclic C-O bond carbonylation are reported. Under the catalysis of Co-2(CO)(8) in the absence of HI as the copromoter, cycloimino esters are carbonylated to afford N-acyllactams in high yields under relatively mild conditions (100-160 degreesC and 200-1000 psi). The reaction is interesting because it opens up the possibility of carbonylation of alcohols in the absence of HI.

  DOI：

  10.1021/ol035616i

文献信息

• Practical and General Manganese-Catalyzed Carbonylative Coupling of Alkyl Iodides with Amides
  作者：Yahui Li、Fengxiang Zhu、Zechao Wang、Jabor Rabeah、Angelika Brückner、Xiao-Feng Wu

  DOI：10.1002/cctc.201601712

  日期：2017.3.20

  carbonylative transformation of alkyl iodides and amides was developed. A variety of imides were prepared in moderate to good yields. Alkyl bromides could also be applied by in situ treatment with NaI to give the corresponding alkyl iodides. Notably, no additives or expensive ligands were required here. As the first example of the carbonylative coupling of alkyl iodides with amides, the simple reaction

  开发了选择性锰催化的烷基碘和酰胺的羰基化转化。以中等至良好的产率制备了各种酰亚胺。烷基溴化物也可以通过用NaI原位处理来施加，以得到相应的烷基碘化物。值得注意的是，这里不需要添加剂或昂贵的配体。作为烷基碘与酰胺的羰基化偶联的第一个例子，锰的简单反应条件和优点使其比常规技术更具吸引力和实用性。从机理上讲，还进行了控制实验和电子顺磁共振波谱学研究，并证明了这一新工艺的根本性质。
• Process for preparing a melt-processable polyamide
  申请人：Koninklijke DSM N.V.

  公开号：EP1449865A1

  公开（公告）日：2004-08-25

  The invention relates to a process for preparing a melt-processable polylactam by contacting caprolactam monomer with an anionic polymerization catalyst, polymerizing said monomer and contacting the resulting polylactam with a protic compound. The anionic polymerization catalyst is chosen from the group of alkali-earth-metal-lactamates and alkali-earth-metal-lactamate forming compounds and the protic compound has a pKa larger than 14. The resulting polylactam has a good melt-stability and very low cyclic dimer content.

  本发明涉及一种制备可熔融加工的聚内酰胺的工艺，其方法是将己内酰胺单体与阴离子聚合催化剂接触，使所述单体聚合，并将得到的聚内酰胺与原生化合物接触。阴离子聚合催化剂选自碱土金属-内酰胺和碱土金属-内酰胺形成化合物，原生化合物的 pKa 大于 14。由此制得的聚内酰胺具有良好的熔融稳定性和极低的环状二聚物含量。
• Amide combinations for cleaning and stripping of electronic parts
  申请人：Dow Global Technologies LLC

  公开号：US11016392B2

  公开（公告）日：2021-05-25

  A solvent consisting essentially of: (A) a first component consisting of N,N-diethylacetamide (DEAC); (B) a second component consisting of 3-methoxy-N, N-dimethyl propionamide (M3DMPA); and (C) an optional third component consisting of one or more glycol ethers or glycol ether acetates; or a solvent consisting essentially of: (1) a first component consisting of one or more acyclic amides of Formula (I): and (2) an optional second component consisting of one or more of DEAC, M3DMPA, N,N-dimethylpropionamide, one or more glycol ethers or glycol ether acetates, and one or more cyclic amides of Formulae (II-IV).

  主要由以下成分组成的溶剂：(A)由 N，N-二乙基乙酰胺（DEAC）组成的第一成分；(B)由 3-甲氧基-N，N-二甲基丙酰胺（M3DMPA）组成的第二成分；以及(C)由一种或多种乙二醇醚或乙二醇醚醋酸酯组成的任选第三成分；或主要由以下成分组成的溶剂：(1) 由一种或多种式（I）的无环酰胺组成的第一组分：和 (2) 由一种或多种 DEAC、M3DMPA、N,N-二甲基丙酰胺、一种或多种乙二醇醚或乙二醇醚醋酸酯和一种或多种式（II-IV）的环酰胺组成的任选第二组分。
• Methods of making prepregs
  申请人：Johns Manville

  公开号：EP2607061B1

  公开（公告）日：2021-05-12
• AMIDE COMBINATIONS FOR CLEANING AND STRIPPING OF ELECTRONIC PARTS
  申请人：Dow Global Technologies LLC

  公开号：EP3649513A1

  公开（公告）日：2020-05-13