ethyl 2-(methyltellanyl)isobutyrate | 474094-06-9

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机含氧阴离子化合物
• 英文名称: ethyl 2-(methyltellanyl)isobutyrate
• 英文别名: Ethyl 2-methyl-2-(methyltellanyl)propanoate；ethyl 2-methyl-2-methyltellanylpropanoate
• CAS: 474094-06-9
• 化学式: C₇H₁₄O₂Te
• 分子量: 257.787
• InChiKey: ABGGCSBXAMRGQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 储存条件：
  2-8°C，惰性气体

反应信息

• 作为反应物：
  描述：

  ethyl 2-(methyltellanyl)isobutyrate 在 苯硫酚 作用下， 反应 1.0h， 生成 异丁酸乙酯
  参考文献：
  名称：

  Arylthiols as Highly Chemoselective and Environmentally Benign Radical Reducing Agents

  摘要：

  Arylthiols serve as excellent environmentally benign reducing agents for organotellurium, organostibine, and organobismuthine compounds under radical conditions. Both small molecules and macromolecules possessing these heteroatorn groups are reduced under moderate thermal conditions to give near quantitative yields in most cases. The reduction shows high chemoselectivity with respect to the heteroatorn compounds the reactivity decreases in the order alkylbismuthines, alkylstibines, and alkyltellurides, while simple alkyl iodides could not be reduced. Alkyltellurides are selectively reduced in the presence of alkyl iodides even when an excess amount of arylthiol is used. Furthermore, alkylstibines are also selectively reduced in the presence of alkyltellurides. Moreover, the reduction conditions are compatible with the presence of a variety of polar functional groups in the substrates, products, and solvents, which are not tolerant under ionic and metal-catalyzed conditions. Carbon-carbon bond formation is possible with use of the carbon-centered radicals that are generated. The results clearly reveal the synthetic utility of arylthiols in organic synthesis.

  DOI：

  10.1021/jo801200b
• 作为产物：
  描述：

  2-溴-2-甲基丙酸乙酯 、 甲基锂 在 碲化氢 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 ethyl 2-(methyltellanyl)isobutyrate
  参考文献：
  名称：

  有机碲介导活性自由基聚合的聚丙烯腈-b-聚（丙烯酸羟乙酯）的动力学和热力学研究

  摘要：

  摘要 以聚丙烯腈-TeMe（PAN-TeMe）和丙烯酸2-羟乙酯（HEA）为原料，通过有机碲介导的活性自由基聚合（TERP）合成聚丙烯腈-b-聚（丙烯酸羟乙酯）（PAN-b-PHEA）， PAN-TeMe 和 PAN-b-PHEA 通过多种方法进行表征。Calvet 微量热仪用于研究 PAN-TeMe 和 HEA 在不同温度（358.15 K、363.15 K、368.15 K、373.15 K、378.15 K 和 383.15 K）下的聚合。得到了不同温度下聚合的动力学方程，聚合表观活化能(E)为16.43±0.17 kJ∙mol-1，指前因子(A)为0.6845±0.0366 s-1。此外，热力学参数包括标准摩尔吉布斯活化自由能 ( Δ G ≠ θ )，

  DOI：

  10.1016/j.tca.2019.178419

文献信息

• Synthesis of Multivalent Organotellurium Chain-Transfer Agents by Post-modification and Their Applications in Living Radical Polymerization
  作者：Weijia Fan、Yasuyuki Nakamura、Shigeru Yamago

  DOI：10.1002/chem.201603682

  日期：2016.11.14

  organotellurium chain‐transfer agents (CTAs) for living radical polymerization were synthesized by post‐modification, which involved the condensation between a carboxylic‐acid‐functionalized CTA and various amines in excellent yields without affecting the reactive tellurium moiety. The CTAs exhibited high synthetic versatility for radical polymerization and gave structurally well‐controlled polymers, such as

  通过后修饰合成了用于活性自由基聚合的功能化或多价有机碲链转移剂（CTA），该修饰涉及羧酸功能化CTA与各种胺之间的缩合，且收率极高，而不会影响反应性碲部分。CTA对自由基聚合反应显示出很高的合成多功能性，并从各种单体中得到结构良好控制的聚合物，例如多臂聚合物。由于所有新的CTA都可通过简单的纯化轻松大规模获得，因此当前方法大大促进了基于有机碲介导的自由基聚合（TERP）的大分子工程。
• アクリル系医薬固形製剤用添加剤
  申请人：三洋化成工業株式会社

  公开号：JP2018058794A

  公开（公告）日：2018-04-12

  【課題】本発明は、医薬固形製剤に、優れた錠剤強度と有効成分放出性を付与する医薬固形製剤用添加剤を提供することを目的とする。【解決手段】特定の構造を有する少なくとも２種の（メタ）アクリルモノマー（ａ）を必須構成単量体とするブロック共重合体を含有する医薬固形製剤用添加剤であって、前記ブロック共重合体が、各（メタ）アクリルモノマー（ａ）が単独重合してなるブロックを有するブロック共重合体であり、前記ブロック共重合体を構成する前記（メタ）アクリルモノマー（ａ）の内、少なくとも１種は、メタクリルモノマーである医薬固形製剤用添加剤。【選択図】なし

  本发明旨在提供一种用于医药固体制剂的添加剂，该添加剂赋予制剂出色的片剂强度和有效成分释放性。解决手段是：提供一种含有至少两种具有特定结构的（甲基）丙烯酸酯单体（a）作为必需构成单体的块共聚物的医药固体制剂用添加剂，其中所述块共聚物是由每个（甲基）丙烯酸酯单体（a）单独聚合而成的块所组成的块共聚物，并且所述（甲基）丙烯酸酯单体（a）构成的块共聚物中，至少一种是用于医药固体制剂的甲基丙烯酸酯单体的添加剂。【选图】无
• Arylthiols as Highly Chemoselective and Environmentally Benign Radical Reducing Agents
  作者：Shigeru Yamago、Atsushi Matsumoto

  DOI：10.1021/jo801200b

  日期：2008.9.19

  Arylthiols serve as excellent environmentally benign reducing agents for organotellurium, organostibine, and organobismuthine compounds under radical conditions. Both small molecules and macromolecules possessing these heteroatorn groups are reduced under moderate thermal conditions to give near quantitative yields in most cases. The reduction shows high chemoselectivity with respect to the heteroatorn compounds the reactivity decreases in the order alkylbismuthines, alkylstibines, and alkyltellurides, while simple alkyl iodides could not be reduced. Alkyltellurides are selectively reduced in the presence of alkyl iodides even when an excess amount of arylthiol is used. Furthermore, alkylstibines are also selectively reduced in the presence of alkyltellurides. Moreover, the reduction conditions are compatible with the presence of a variety of polar functional groups in the substrates, products, and solvents, which are not tolerant under ionic and metal-catalyzed conditions. Carbon-carbon bond formation is possible with use of the carbon-centered radicals that are generated. The results clearly reveal the synthetic utility of arylthiols in organic synthesis.
• Investigation on the kinetics and thermodynamics of polyacrylonitrile-b-poly(hydroxyethyl acrylate) via organotellurium-mediated living radical polymerization by micro-calorimeter
  作者：Shijie Zhang、Jiaoqiang Zhang、Huimin Shi、Zhenguo Gao、Kaichang Kou

  DOI：10.1016/j.tca.2019.178419

  日期：2019.12

  PAN-TeMe and PAN-b-PHEA were characterized by several methods. A Calvet micro-calorimeter was used to investigate the polymerization of PAN-TeMe and HEA at different temperatures (358.15 K, 363.15 K, 368.15 K, 373.15 K, 378.15 K and 383.15 K). The kinetic equations of polymerization at different temperatures were obtained, and the apparent activation energy (E) of polymerization is 16.43±0.17 kJ∙mol−1 and

  摘要 以聚丙烯腈-TeMe（PAN-TeMe）和丙烯酸2-羟乙酯（HEA）为原料，通过有机碲介导的活性自由基聚合（TERP）合成聚丙烯腈-b-聚（丙烯酸羟乙酯）（PAN-b-PHEA）， PAN-TeMe 和 PAN-b-PHEA 通过多种方法进行表征。Calvet 微量热仪用于研究 PAN-TeMe 和 HEA 在不同温度（358.15 K、363.15 K、368.15 K、373.15 K、378.15 K 和 383.15 K）下的聚合。得到了不同温度下聚合的动力学方程，聚合表观活化能(E)为16.43±0.17 kJ∙mol-1，指前因子(A)为0.6845±0.0366 s-1。此外，热力学参数包括标准摩尔吉布斯活化自由能 ( Δ G ≠ θ )，