9-(furan-2-yl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione | 15781-69-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 9-(furan-2-yl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione
• 英文别名: 9-(2-furyl)-3,3,6,6-tetramethyl-3,4,6,7-tetrahydro-2H-xanthene-1,8(5H,9H)-dione；9-(furan-2-yl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-2H-xanthene-1,8-dione；9-[2]furyl-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-2H-xanthene-1,8-dione；9-[2]Furyl-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-2H-xanthen-1,8-dion；9-(Furan-2-yl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexa-hydro-1h-xanthene-1,8(2h)-dione；9-(furan-2-yl)-3,3,6,6-tetramethyl-4,5,7,9-tetrahydro-2H-xanthene-1,8-dione
• CAS: 15781-69-8
• 化学式: C₂₁H₂₄O₄
• 分子量: 340.419
• InChiKey: IRMDKPUJUVIIDP-UHFFFAOYSA-N

物化性质

• 熔点：
  62-64 °C
• 沸点：
  484.5±45.0 °C(Predicted)
• 密度：
  1.20±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  25
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  56.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-羟基-5,5-二甲基环己-2-烯-1-酮 在 哌啶 、 phosphorus pentoxide 作用下， 以 乙醇 、 异丙醇 为溶剂， 反应 4.0h， 生成 9-(furan-2-yl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione
  参考文献：
  名称：

  1,3-二氧代环己烷化合物在各种介质中形成十氢ac啶-1,8-二酮的特殊性

  摘要：

  DOI：

  10.1007/bf02269536

文献信息

• 4-Imidazol-1-yl-butane-1-sulfonic acid or a novel liquid salt? The NMR analysis and dual solvent-catalytic efficiency for one-pot synthesis of xanthenes
  作者：Nader Ghaffari Khaligh、Lim Shi Teng、Ong Chiu Ling、Mohd Rafie Johan、Juan Joon Ching

  DOI：10.1016/j.molliq.2019.01.041

  日期：2019.3

  structure of the product was investigated by the NMR analysis in CD3OD and DMSO‑d6. This work demonstrated that 4-imidazol-1-yl-butane-1-sulfonic acid could not be obtained through the above reaction and the mixture of zwitterionic (I) and ionic (II) structure is produced. The structure of the liquid salt (I + II) was characterized and analyzed by 2D NMR. Then, the dual solvent-catalytic efficiency of

  咪唑和1,4-丁烷磺酸等摩尔混合物的反应在90°C下在乙苯中进行12 h，并通过NMR分析在CD 3 OD和DMSO- d 6中研究产物的结构。这项工作表明通过上述反应不能获得4-咪唑-1-基-丁烷-1-磺酸，并且生成了两性离子（I）和离子（II）结构的混合物。通过2D NMR对液态盐（I + II）的结构进行表征和分析。然后，在温和的条件下研究了液态盐（I + II）的双溶剂催化效率，以合成多种黄嘌呤，从而在较短的反应时间内以良好的产率提供了所需的产物。研究了液态盐（I + II）的可回收性，其后三个运行的平均回收率为89％。循环使用的液态盐即使经过3次运行也没有表现出明显的催化活性损失，其结构与新鲜液态盐（I + II）相同。
• Tungstophosphoric acid nanoparticles supported on polyamic acid: A mild and recoverable heterogeneous catalyst for the selective synthesis of mono and bulky bis(1,8-dioxooctahydroxanthene)s under solvent-free conditions
  作者：Masoud Nasr-Esfahani、Zahra Rafiee、Hassan Kashi

  DOI：10.1080/10426507.2015.1100185

  日期：2016.5.3

  8-dioxooctahdroxanthene) were selectively synthesized using tungstophosphoric acid nanoparticles supported on polyamic acid (TPA/PAA) as a new catalyst in solvent-free conditions. The high purity products were isolated and catalyst was easily separated in simple work-up and was recycled several times without loss of reactivity under the described reaction conditions. The reaction is characterized by short reaction

  摘要 使用负载在聚酰胺酸 (TPA/PAA) 上的磷钨酸纳米粒子作为无溶剂条件下的新型催化剂，选择性地合成了一系列 1,8-二氧代八氧杂蒽衍生物和一些拥挤的双（1,8-二氧代八氧杂蒽）。分离出高纯度产物，催化剂在简单的后处理中很容易分离，并在所述反应条件下循环多次而不会损失反应性。该反应具有反应时间短、效率高、反应条件环保等特点。图形概要
• Grafting of sulphamic acid on functionalized sawdust: A novel solid acid catalyst for the synthesis of 1,8-dioxo-octahydroxanthenes
  作者：Shrikrishna Karhale

  DOI：10.1007/s11164-020-04136-5

  日期：2020.6

  Abstract A solid acid catalyst bearing sulphamic acid on sawdust (SA@Sawdust) was designed as a novel heterogeneous catalyst. The structure of prepared catalyst was assessed by various spectroscopic techniques such as FT-IR, field emission scanning electron microscopy and energy dispersive X-ray, thermogravimetric analysis, solid-state CP/MAS 13C-NMR spectroscopy, and CHNS analysis. The efficiency

  摘要 设计了一种在木屑上带有氨基磺酸的固体酸催化剂（SA @ Sawdust）作为新型多相催化剂。制备的催化剂的结构通过各种光谱技术进行了评估，例如FT-IR，场发射扫描电子显微镜和能量色散X射线，热重分析，固态CP / MAS 13C-NMR光谱和CHNS分析。探索了制备的催化剂的效率，以合成各种1,8-二氧-八氢氧杂蒽衍生物。发现温和的反应条件与多种官能团更相容。所获得的产物可以通过简单的过滤方便地从反应混合物中分离出来，并且催化剂被回收并重新用于下一个循环而不会显着降低催化效率。该合成路线的诱人之处在于操作简便，反应时间短，转化率高，底物范围广，后处理步骤容易以及催化剂的可重复使用性。 图形摘要
• Magnetic Fe–Cr–Ni oxide alloy nano-belts prepared from the chemical decomposition of a stainless steel screw (a top-down approach): an efficient and cheap catalyst for multicomponent reactions
  作者：Milad Kazemnejadi、Zeinab Sharafi、Boshra Mahmoudi、Atefeh Zeinali、Mohammad Ali Nasseri

  DOI：10.1007/s13738-019-01814-z

  日期：2020.4

  A new, cheap, and accessible method has been used for the preparation of nano-belts from the chemical decomposition (top-down approach) of a cheap stainless steel screw and found as an efficient magnetically recyclable nanocatalyst for the preparation of quinolines and 1,8-dioxo-octahydroxanthenes under mild reaction conditions. The nano-belts, Fe–Cr–Ni oxide alloy, was prepared in a two-step synthesis and characterized with various instrumental methods. Due to magnetic property of the screw (a ferritic-alloy), the resultant nano-belts is magnetic. Magnetic Fe–Cr–Ni alloy nano-belts were applied toward efficient preparation of quinolines and 1,8-dioxo-octahydroxanthenes under mild conditions. The catalyst could be readily recovered and recycled for several consecutive runs, while it suffers from a very low metal leaching and subsequently efficiency drop.

  一种新的、廉价且易得的方法已被用于从廉价不锈钢螺丝的化学分解（自上而下的方法）中制备纳米带，并发现其在温和反应条件下作为高效的磁性可回收纳米催化剂，用于喹啉和1,8-二氧杂-八氢氧杂蒽的制备。这种纳米带，即Fe–Cr–Ni氧化物合金，是通过两步合成法制备的，并使用多种仪器方法进行了表征。由于螺丝（一种铁素体合金）的磁性特性，所得纳米带也具有磁性。磁性Fe–Cr–Ni合金纳米带在温和条件下被应用于高效制备喹啉和1,8-二氧杂-八氢氧杂蒽。该催化剂可以轻易地回收并在多次连续运行中循环使用，同时金属溶出现象极少，因此催化效率几乎不会下降。
• Synthesis and Study of Catalytic, Anti–Bacterial, Anti–Oxidant, and DNA Cleavage Properties of Ag–Co and Ag–Ni Magnetic Nanoparticles
  作者：Keveh Pravanak Boroujeni、Mansooreh Shahrokh、Jamshid Karvani、Niloofar Moradi、Ahmad Farokhnia、Mohsen Mobini

  DOI：10.17344/acsi.2018.4376

  日期：——

  Magnetic Ag–Co and Ag–Ni alloy nanoparticles were prepared through a chemical reduction method using their corresponding [Co(NH 3 ) 6 ]Cl 3 and [Ni(C 2 O 4 ) 2 ]K 2 complexes, and AgNO 3 . In this reaction, hydrazine monohydrate was used as reducing agent. The obtained nanoparticles were characterized by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), energy dispersive

  磁性Ag-Co和Ag-Ni合金纳米粒子是通过化学还原法使用相应的[Co（NH 3）6] Cl 3和[Ni（C 2 O 4）2] K 2配合物以及AgNO 3制备的。在该反应中，使用一水合肼作为还原剂。通过傅立叶变换红外光谱（FT-IR），扫描电子显微镜（SEM），能量色散光谱（EDS），X射线衍射（XRD）和振动样品磁力计（VSM）对获得的纳米颗粒进行表征。Ag-Co和Ag-Ni纳米合金在5,5-二甲基-1,3-环己二酮（二甲酮）与芳香醛的反应中制备1,8-二氧辛八氢氧杂蒽中表现出出色的催化性能。催化剂由外部永磁体分离并重复使用。两个都，