([3-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)phenyl]methanal) | 1203486-49-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: ([3-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)phenyl]methanal)
• 英文别名: 3-((2,2-Dimethyl-1,3-dioxolan-4-yl)methoxy)benzaldehyde；3-[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]benzaldehyde
• CAS: 1203486-49-0
• 化学式: C₁₃H₁₆O₄
• 分子量: 236.268
• InChiKey: SEUSLSPELJZEOB-UHFFFAOYSA-N

物化性质

• 沸点：
  350.9±22.0 °C(Predicted)
• 密度：
  1.123±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ([3-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)phenyl]methanal) 在 sodium cyanoborohydride 、 溶剂黄146 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 12.0h， 以100%的产率得到([3-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)phenyl]methanol)
  参考文献：
  名称：

  Synthesis and self-assembly of polyhydroxylated and electropolymerizable block copolymers

  摘要：

  A facile synthetic strategy for preparing hydroxylated polymethacrylate amphiphilic block copolymers (PCzMMA-b-PBMMA, PFlMMA-b-PBMMA) incorporated with primary and secondary hydroxyl groups and electroactive moieties along the polymer backbone is reported. Full characterization, structure-property relationship and self-assembly of these polymers are discussed. Due to interplay of hydrophobic/hydrophilic interactions, PCzMMA-b-PBMMA formed a layered lattice and PFlMMA-b-PBMMA showed a vesicular morphology. Electropolymerization of the electroactive units led to the formation of cross-conjugated polymer network in solution and in thin films. The network structure was characterized with a range of spectroscopic techniques. Such highly processable polymers may be of interest to applications in which a conducting amphiphilic films with strong adhesion to various substrates are required. (C) 2014 Wiley Periodicals, Inc.

  DOI：

  10.1002/pola.27234
• 作为产物：
  描述：

  丙酮缩甘油 在 18-冠醚-6 、 potassium carbonate 、 sodium hydroxide 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 121.0h， 生成 ([3-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)phenyl]methanal)
  参考文献：
  名称：

  Synthesis and self-assembly of polyhydroxylated and electropolymerizable block copolymers

  摘要：

  A facile synthetic strategy for preparing hydroxylated polymethacrylate amphiphilic block copolymers (PCzMMA-b-PBMMA, PFlMMA-b-PBMMA) incorporated with primary and secondary hydroxyl groups and electroactive moieties along the polymer backbone is reported. Full characterization, structure-property relationship and self-assembly of these polymers are discussed. Due to interplay of hydrophobic/hydrophilic interactions, PCzMMA-b-PBMMA formed a layered lattice and PFlMMA-b-PBMMA showed a vesicular morphology. Electropolymerization of the electroactive units led to the formation of cross-conjugated polymer network in solution and in thin films. The network structure was characterized with a range of spectroscopic techniques. Such highly processable polymers may be of interest to applications in which a conducting amphiphilic films with strong adhesion to various substrates are required. (C) 2014 Wiley Periodicals, Inc.

  DOI：

  10.1002/pola.27234

文献信息

• [EN] BENZIMIDAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS<br/>[FR] BENZIMIDAZOLES ET ANALOGUES ASSOCIÉS EN TANT QUE MODULATEURS DE SIRTUINE
  申请人：SIRTRIS PHARMACEUTICALS INC

  公开号：WO2010003048A1

  公开（公告）日：2010-01-07

  Provided herein are sirtuin-modulating compounds of formula (II) The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

  本文提供了公式（II）的调节sirtuin的化合物。这些调节sirtuin的化合物可用于延长细胞的寿命，并用于治疗和/或预防各种疾病和紊乱，包括与衰老或压力有关的疾病或紊乱、糖尿病、肥胖、神经退行性疾病、心血管疾病、血液凝块紊乱、炎症、癌症、潮红以及那些会受益于增加线粒体活性的疾病或紊乱。还提供了包含调节sirtuin化合物与另一治疗剂结合的组合物。
• BENZIMIDAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS
  申请人：Vu Chi B

  公开号：US20110124637A1

  公开（公告）日：2011-05-26

  Provided herein are sirtuin-modulating compounds of formula (II). The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders relating to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

  本文提供的是公式（II）的sirtuin调节化合物。这些sirtuin调节化合物可用于延长细胞寿命，并治疗和/或预防各种疾病和疾患，包括与衰老或压力有关的疾病或疾患、糖尿病、肥胖症、神经退行性疾病、心血管疾病、血液凝块疾病、炎症、癌症和/或潮红，以及需要增加线粒体活性的疾病或疾患。还提供了包含sirtuin调节化合物与另一种治疗剂的组合物。
• Synthesis and self-assembly of polyhydroxylated and electropolymerizable block copolymers
  作者：Satyananda Barik、Suresh Valiyaveettil

  DOI：10.1002/pola.27234

  日期：2014.8.1

  A facile synthetic strategy for preparing hydroxylated polymethacrylate amphiphilic block copolymers (PCzMMA-b-PBMMA, PFlMMA-b-PBMMA) incorporated with primary and secondary hydroxyl groups and electroactive moieties along the polymer backbone is reported. Full characterization, structure-property relationship and self-assembly of these polymers are discussed. Due to interplay of hydrophobic/hydrophilic interactions, PCzMMA-b-PBMMA formed a layered lattice and PFlMMA-b-PBMMA showed a vesicular morphology. Electropolymerization of the electroactive units led to the formation of cross-conjugated polymer network in solution and in thin films. The network structure was characterized with a range of spectroscopic techniques. Such highly processable polymers may be of interest to applications in which a conducting amphiphilic films with strong adhesion to various substrates are required. (C) 2014 Wiley Periodicals, Inc.