3-[3-(4-Methoxyphenyl)-1,2-oxazol-5-yl]propan-1-ol | 1422283-17-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-[3-(4-Methoxyphenyl)-1,2-oxazol-5-yl]propan-1-ol
• 英文别名: 3-[3-(4-methoxyphenyl)-1,2-oxazol-5-yl]propan-1-ol
• CAS: 1422283-17-7
• 化学式: C₁₃H₁₅NO₃
• mdl: MFCD26426164
• 分子量: 233.267
• InChiKey: ZBCXIKXMNFOXOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.307
• 拓扑面积：
  55.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  对甲氧基苯甲醛肟 在 N-氯代丁二酰亚胺 、 copper diacetate 、 potassium hydrogencarbonate 、 sodium ascorbate 作用下， 以 水 、 N,N-二甲基甲酰胺 、 叔丁醇 为溶剂， 反应 1.0h， 生成 3-[3-(4-Methoxyphenyl)-1,2-oxazol-5-yl]propan-1-ol
  参考文献：
  名称：

  Larvicidal isoxazoles: Synthesis and their effective susceptibility towards Aedes aegypti larvae

  摘要：

  Twenty 3,5-disubstituted isoxazoles have been synthesized and tested against fourth instar Aedes aegypti larvae. In the synthesis of title compounds, modifications have been made in the C-5 side-chain with a view to test their larvicidal activity. These isoxazoles have been obtained by 1,3-dipolar cycloaddition of arylnitrile oxides to terminal alkynes which furnished the desired products in 20% to 79% yields. A comparative study of the larvicidal activity between 3-(3-aryl-isoxazol-5-yl)-propan-1-ols and 3-(3-aryl-isoxazol-5-yl)-propionic acids clearly demonstrated that the latter compounds possess much better larvicidal activity than the former. We also tested two esters, viz., methyl 3-[3-(phenyl)-isoxazole-5-yl] propionate and methyl 3-[3-(4-chlorophenyl)-isoxazole-5-yl] propionate, where the latter presented an excellent larvicidal profile. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.12.006

文献信息

• Larvicidal isoxazoles: Synthesis and their effective susceptibility towards Aedes aegypti larvae
  作者：Diana C.B. da Silva-Alves、Janaína V. dos Anjos、Nery N.M. Cavalcante、Geanne K.N. Santos、Daniela M.do A.F. Navarro、Rajendra M. Srivastava

  DOI：10.1016/j.bmc.2012.12.006

  日期：2013.2

  Twenty 3,5-disubstituted isoxazoles have been synthesized and tested against fourth instar Aedes aegypti larvae. In the synthesis of title compounds, modifications have been made in the C-5 side-chain with a view to test their larvicidal activity. These isoxazoles have been obtained by 1,3-dipolar cycloaddition of arylnitrile oxides to terminal alkynes which furnished the desired products in 20% to 79% yields. A comparative study of the larvicidal activity between 3-(3-aryl-isoxazol-5-yl)-propan-1-ols and 3-(3-aryl-isoxazol-5-yl)-propionic acids clearly demonstrated that the latter compounds possess much better larvicidal activity than the former. We also tested two esters, viz., methyl 3-[3-(phenyl)-isoxazole-5-yl] propionate and methyl 3-[3-(4-chlorophenyl)-isoxazole-5-yl] propionate, where the latter presented an excellent larvicidal profile. (C) 2012 Elsevier Ltd. All rights reserved.