5-butyl-3,3-dimethyldihydrofuran-2-one | 62581-37-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 5-butyl-3,3-dimethyldihydrofuran-2-one
• 英文别名: 5-Butyl-3,3-dimethyloxolan-2-one
• CAS: 62581-37-7
• 化学式: C₁₀H₁₈O₂
• 分子量: 170.252
• InChiKey: XQFBUZXWKBZMHB-UHFFFAOYSA-N

物化性质

• 沸点：
  245.4±8.0 °C(Predicted)
• 密度：
  0.918±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  丁基环氧乙烷 、 1-甲氧基-1-(三甲基甲硅氧基)-2-甲基-1-丙烯 在 四丁基氟化铵 作用下， 以 neat (no solvent) 为溶剂， 反应 5.0h， 以81%的产率得到5-butyl-3,3-dimethyldihydrofuran-2-one
  参考文献：
  名称：

  A Catalytic Approach to the Metal-Free Reaction of Epoxides with Ketene Silyl Acetals for Accessing γ-Lactones

  摘要：

  The first catalytic approach to the nucleophilic addition of silyl ketene acetals 2 to epoxides 1 is reported. The defined protocol is metal-free using tetrabutylammonioum fluoride as the catalyst. It works in a very efficient manner under solvent-free conditions (SolFC) allowing ?-lactones 3 to be directly obtained with high regioselectivities and yields.

  DOI：

  10.1021/ol502855q

文献信息

• A Catalytic Approach to the Metal-Free Reaction of Epoxides with Ketene Silyl Acetals for Accessing γ-Lactones
  作者：Simona Bonollo、Amanollah Zarei Ahmady、Chiara Petrucci、Assunta Marrocchi、Ferdinando Pizzo、Luigi Vaccaro

  DOI：10.1021/ol502855q

  日期：2014.11.7

  The first catalytic approach to the nucleophilic addition of silyl ketene acetals 2 to epoxides 1 is reported. The defined protocol is metal-free using tetrabutylammonioum fluoride as the catalyst. It works in a very efficient manner under solvent-free conditions (SolFC) allowing ?-lactones 3 to be directly obtained with high regioselectivities and yields.