Ethane-1,2-diol;pentanedial | 85408-16-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Ethane-1,2-diol;pentanedial
• CAS: 85408-16-8
• 化学式: C7H14O4
• 分子量: 162.18
• InChiKey: FZOYTUIHJYCZFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.47
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Virucidal low toxicity compositions
  申请人：WAVE ENERGY SYSTEMS, INC.

  公开号：EP0375149A2

  公开（公告）日：1990-06-27

  Very potent, stable, odorless, and phenol-free virucidal solutions are active at high dilution when used for surface decontamination of animate and inanimate objects. The virucidal compositions described are efficacious in a matter of minutes against both the lipophilic and the more resistant hydrophilic viruses. The three active ingredients in these virucidal compositions are the glutaraldehyde monomer in equilibrium with its hydrates and polymers, hydrogen-bonded glycol molecules to eliminate aldehydes odor, and an anionic surfactant of the alkyl sulfate, alkyl sulfonate, alcohol sulfate or alkyl aryl sulfonate type. A preferred anionic surfactant would be the Sodium Dodecyl Sulfate (SDS), which exhibits strong cidal synergism against the Herpes Simplex Virus type 1 when mixed at a concentration as low as 0.0005% in diluted glutaraldehyde aqueous solutions (0.0025%). Improved virucidal killing at higher dilutions of the same formula were observed with the more resistant Coxsackie B viruses. Because of the low concentration of active ingredients, these solutions exhibit a very low toxicity, making them suitable for topical applications as antiseptics.

  非常有效、稳定、无味、无酚的杀病毒剂溶液在用于有生命和无生命物体的表面去污时，稀释度越高越有效。所述杀病毒组合物对亲脂性病毒和抗药性较强的亲水性病毒都能在几分钟内发挥功效。这些杀病毒组合物中的三种活性成分是戊二醛单体（与其水合物和聚合物处于平衡状态）、消除醛类气味的氢键乙二醇分子以及硫酸烷基酯、磺酸烷基酯、硫酸醇酯或芳基磺酸烷基酯类阴离子表面活性剂。首选的阴离子表面活性剂是十二烷基硫酸钠（SDS），当十二烷基硫酸钠与浓度低至 0.0005%的戊二醛稀释水溶液（0.0025%）混合时，对 1 型单纯疱疹病毒有很强的杀灭增效作用。对于抗药性较强的柯萨奇 B 型病毒，在相同配方的较高稀释度下可提高杀毒效果。由于活性成分的浓度较低，这些溶液的毒性很低，因此适合作为局部杀菌剂使用。
• Oderless mycobactericidal compositions
  申请人：WAVE ENERGY SYSTEMS, INC.

  公开号：EP0407672A2

  公开（公告）日：1991-01-16

  Efficacious phenol-free mycobactericidal liquid compositions having low odor and irritation potential are disclosed. These compositions consist of a solvent containing a glycol, a 2 to 6 carbon atom aldehyde, specific anionic surfactants, and buffer salts to stabilize the pH in the 6 to 7.4 range. The ratio of glycol to aldehyde is comprised between 0.1 and 6.0. The lower this ratio, the greater the mycobactericidal activity. The new odorless compositions can kill Mycobacterium tuberculosis (EPA quantitative procedure) in 10 minutes or less at 20°C.

  本发明公开了具有低气味和低刺激性的高效无酚分枝杆菌杀菌液体组合物。这些组合物由含有乙二醇的溶剂、2 至 6 个碳原子的醛、特定的阴离子表面活性剂以及将 pH 值稳定在 6 至 7.4 范围内的缓冲盐组成。乙二醇与醛的比例在 0.1 至 6.0 之间。该比例越低，杀灭分枝杆菌的活性越强。新的无味组合物可以在 20°C 温度下 10 分钟或更短时间内杀死结核分枝杆菌（EPA 定量程序）。
• Liquid sterilising composition
  申请人：Whiteley, Reginald Keith

  公开号：EP0251743B1

  公开（公告）日：1994-09-07
• EP0936862A4
  申请人：——

  公开号：EP0936862A4

  公开（公告）日：2002-04-17
• READY-TO-USE GLUTARALDEHYDE CONCENTRATES
  申请人：Whiteley Industries Pty. Ltd.

  公开号：EP0936862A1

  公开（公告）日：1999-08-25