4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine | 64607-51-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine
• 英文别名: 4,5,6,7-tetrahydro-benzo[b]thiophen-4-ylamine；4,5,6,7-tetrahydro-1-benzothiophen-4-amine
• CAS: 64607-51-8
• 化学式: C₈H₁₁NS
• 分子量: 153.248
• InChiKey: VPBWFYNSOJYNJP-UHFFFAOYSA-N

物化性质

• 沸点：
  258.0±28.0 °C(Predicted)
• 密度：
  1.149±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  54.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine 在 甲酸 、 cerium (IV) ammonium nitrate 作用下， 以 乙醚 、 水 、 溶剂黄146 、 甲苯 为溶剂， 生成 (-)-N-(4,5,6,7-tetrahydro-7-oxobenzo[b]thien-4-yl)formamide
  参考文献：
  名称：

  Compositions containing 4,5,6,7-tetrahydrobenz[b]thien-4-yl-ureas or

  摘要：

  这份披露描述了一种新颖的方法，通过向兽医同温动物投予一定量的环戊烷基硫代脲或硫脲，以提高饲料效率并加快生长速度。

  公开号：

  US04036979A1
• 作为产物：
  描述：

  4-(2-噻吩基)丁酸 在 磷酸 、 ammonium acetate 、 乙酸酐 、 sodium cyanoborohydride 作用下， 以 甲醇 为溶剂， 反应 170.5h， 生成 4,5,6,7-tetrahydrobenzo[b]thiophen-4-amine
  参考文献：
  名称：

  New structures able to prevent the inhibition by hydroxyl radicals of glutamate transport in cultured astrocytes

  摘要：

  4,5,6,7-Tetrahydro-benzothiophen-7-ylamines, 4,5,6,7-tetrahydro-benzothiophen-4-ylamines and 5,6-dihydro-4H-thieno[2,3-b] thiopyran-4-ylamines were designed, synthesized, and tested as OH. radical scavengers. Most of them displayed chemical scavenging properties better than or in the same range as salicylic acid. Moreover, some compounds were able to protect in vitro the astroglial glutamate transporters against inhibitory action of radicals promoted by xanthine/xanthine oxidase. Thus, such compounds might be useful for lowering the large amounts of excitotoxic glutamate liberated during acute CNS diseases: they might protect the glutamate reuptake in astrocytes from the inhibitory action due to radicals co-liberated with glutamate. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(99)80011-7

文献信息

• ION CHANNEL INHIBITOR COMPOUNDS FOR CANCER TREATMENT
  申请人：Centre National de la Recherche Scientifique

  公开号：US20210009581A1

  公开（公告）日：2021-01-14

  The present invention concerns a compound of following general formula (I): where: either R is an R 1 group and R′ is an -A 1 -Cy 1 group, or R is an -A 1 -Cy 1 group and R′ is an R 1 group, R 1 particularly being H or (C 1 -C 6 )alkyl group; A 1 being an —NH— radical or —NH—CH 2 — radical; Cy 1 particularly being a phenyl group, A is a fused (hetero)aromatic ring having 5 to 7 atoms, for use for treating cancer.

  本发明涉及以下一般式（I）的化合物： 其中： R是R1基团且R′是-A1-Cy1基团，或者R是-A1-Cy1基团且R′是R1基团， 其中R1特别是H或（C1-C6）烷基基团； A1是—NH—基团或—NH—CH2—基团； Cy1特别是苯基， A是具有5到7个原子的融合（杂）芳香环， 用于治疗癌症。
• 3,4-DISUBSTITUTED 3-CYCLOBUTENE-1,2-DIONES AND USE THEREOF
  申请人：ALLERGAN, INC.

  公开号：US20190047947A1

  公开（公告）日：2019-02-14

  Described herein are compounds, or pharmaceutically acceptable salts thereof, of the following formula: The compounds are useful for treating inflammatory and autoimmune diseases.

  本文描述了以下结构的化合物或其药用盐： 这些化合物可用于治疗炎症性和自身免疫性疾病。
• Process for preparing 4,5,6,7-tetrahydro-7-oxobenzo[b]thiophenes and
  申请人：American Cyanamid Co.

  公开号：US04332724A1

  公开（公告）日：1982-06-01

  There is provided a process for the preparation of an amido or an ureido derivative of certain 4,5,6,7-tetrahydro-7-oxobenzo[b]thiophenes or certain 1,2,3,4-tetrahydro-4-oxonaphthalenes which can be employed as an animal growth regulant. The process comprises: oxidizing in the presence of a cobalt catalyst a compound having the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each a substituent selected from the group consisting of alkanoyl C.sub.1 -C.sub.7, halogen-substituted alkanoyl C.sub.1 -C.sub.7, carboalkoxy C.sub.1 -C.sub.4, ##STR2## and ##STR3## R.sub.3 is selected from the group consisting of hydrogen and alkyl C.sub.1 -C.sub.4 ; R.sub.4 is selected from the group consisting of hydr ogen, alkyl C.sub.1 -C.sub.8, alkanoyl C.sub.2 -C.sub.4, halogen-substituted alkanoyl (C.sub.2 -C.sub.4), and ##STR4## and when the ##STR5## moiety is cyclized each represents a moiety selected from the group consisting of succinimido, maleimido and phthalimido; X and Y are each a radical selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, nitro, alkyl C.sub.1 -C.sub.4 ; the racemic mixtures and the optical isomers thereof.

  提供了一种制备某些4,5,6,7-四氢-7-氧基苯并[b]噻吩或某些1,2,3,4-四氢-4-氧基萘的酰胺或脲衍生物的过程，该过程可用作动物生长调节剂。该过程包括：在钴催化剂存在下氧化具有以下式的化合物：其中R.sub.1和R.sub.2分别是从羰基C.sub.1-C.sub.7、卤代烷基C.sub.1-C.sub.7、羧烷氧基C.sub.1-C.sub.4、和R.sub.3选自氢和烷基C.sub.1-C.sub.4的取代基组成的羧基；R.sub.4选自氢、烷基C.sub.1-C.sub.8、羰基C.sub.2-C.sub.4、卤代烷基(C.sub.2-C.sub.4)、和当##STR5##基团环化时，每个代表从琥珀酰亚胺、马来酰亚胺和邻苯二甲酰亚胺组成的基团；X和Y分别是从氢、氟、氯、溴、碘、硝基、烷基C.sub.1-C.sub.4组成的基团中选择的基团；它们的外消旋混合物和光学异构体。
• SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS
  申请人：Chow Ken

  公开号：US20080255239A1

  公开（公告）日：2008-10-16

  Therapeutic compounds, and methods, compositions, and medicaments related thereto are disclosed herein.

  本文揭示了治疗化合物、方法、组合物和相关药物。
• Deconstructive Oxygenation of Unstrained Cycloalkanamines
  作者：Jian‐Wu Zhang、Yuan‐Rui Wang、Jia‐Hao Pan、Yi‐Heng He、Wei Yu、Bing Han

  DOI：10.1002/anie.201914623

  日期：2020.3.2

  further oxygenation by 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and m-cholorperoxybenzoic acid (mCPBA). Consequently, a series of 1,2,4-triazole-containing acyclic carbonyl compounds were efficiently produced. This protocol features a one-pot operation, mild reaction conditions, high regioselectivity and ring-opening efficiency, broad substrate scope, and is compatible with alkaloids, osamines

  使用自动氧化芳构化促进的C（sp3）-C（sp3）键裂解策略，首次开发了未应变的伯环烷胺的解构氧化。这种无金属的方法涉及环烷胺与酰氯的取代反应，随后进行自氧化环氧化，以原位生成预芳族化合物，然后进行N自由基促进的开环，并通过2,2,6,6-进一步氧合四甲基哌啶-1-氧基（TEMPO）和间胆过氧苯甲酸（mCPBA）。因此，有效地生产了一系列含1,2,4-三唑的无环羰基化合物。该方案具有一锅操作，温和的反应条件，高区域选择性和开环效率，广泛的底物范围，并且与生物碱，osamines和肽以及类固醇兼容。