6-O-Acetyl-glucose | 7286-45-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-O-Acetyl-glucose
• 英文别名: 6-O-acetyl-D-glucose；[(2R,3R,4S,5R)-2,3,4,5-tetrahydroxy-6-oxohexyl] acetate
• CAS: 7286-45-5
• 化学式: C₈H₁₄O₇
• 分子量: 222.195
• InChiKey: VFPUCPVAZOMVLI-LXGUWJNJSA-N

物化性质

• 熔点：
  146 °C
• 沸点：
  483.6±45.0 °C(Predicted)
• 密度：
  1.452±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  124
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• STIMULUS-TRIGGERED PRODRUGS
  申请人：Cohen Seth M.

  公开号：US20110312905A1

  公开（公告）日：2011-12-22

  Set forth herein, inter alia, are compositions and methods for treating diseases with prodrugs. Provided herein are prodrug compositions for inhibiting the function of proteins, compositions and methods for treating diseases associated with oxidative compounds, oxidatively-sensitive prodrugs of inhibitors of metalloproteases. and methods of inhibiting metalloproteases using oxidatively-sensitive prodrugs.

  本文中提供了用于用前药治疗疾病的组合物和方法，其中包括用于抑制蛋白质功能的前药组合物，用于治疗与氧化化合物相关疾病的组合物和方法，以及金属蛋白酶抑制剂的氧化敏感前药。和使用氧化敏感前药抑制金属蛋白酶的方法。
• Novel phytol derived immunoadjuvants and their use in vaccine formulations
  申请人：Ghosh K. Swapan

  公开号：US20050158329A1

  公开（公告）日：2005-07-21

  This invention relates to a novel immunoadjuvant, an adjuvant component, and vaccines containing the adjuvant component. The adjuvant includes phytol or a phytol derivative. The adjuvant component, when combined with a soluble or particulate antigen, provides a vaccine with an enhanced ability to induce both humoral and cytotoxic immune responses while displaying reduced toxicity and/or adverse side effects over vaccines that include the antigen but without the benefit of this adjuvant component.

  该发明涉及一种新型免疫佐剂、一种佐剂成分以及含有该佐剂成分的疫苗。该佐剂包括萜醇或萜醇衍生物。当该佐剂成分与可溶性或颗粒状抗原结合时，提供了一种疫苗，具有增强诱导细胞免疫和体液免疫反应能力，同时显示出比不含该佐剂成分的抗原疫苗更低的毒性和/或不良副作用。
• Process for production of chlorinated sucrose based on hydrophobic affinity chromatography
  申请人：Ratnam Rakesh

  公开号：US20100222570A1

  公开（公告）日：2010-09-02

  This invention relates to a process for selective capture, isolation and purification of chlorinated sucrose compounds, including chlorinated sucrose, their precursors and derivatives, including trichlorogalactosucrose (TGS), directly from chlorinated reaction mixture by column chromatography on adsorbents and under conditions which result in specific and selective affinity towards one or more of chlorinated sucrose compound. The process also integrates de-esterification of chlorinated sucrose esters adsorbed on the adsorbent while they are being treated with desorbent. The process also provides a novel approach to concentration and crystallization of TGS. The chlorinated sucrose derivatives, including TGS, thus isolated are substantially free from most impurities, salts and organic solvents. The process has high recovery of more than 95% in terms of desired chlorinated sucrose derivatives including TGS.

  本发明涉及一种从氯化反应混合物中通过吸附剂柱层析和在特定条件下对氯化蔗糖化合物，包括氯化蔗糖、其前体和衍生物，如三氯半乳糖蔗糖（TGS）进行选择性捕获、分离和纯化的过程。该过程还结合了在吸附剂上吸附的氯化蔗糖酯在处理解吸剂时的去酯化。该过程还提供了一种新的浓缩和结晶TGS的方法。因此，分离出的包括TGS在内的氯化蔗糖衍生物基本上不含大多数杂质、盐和有机溶剂。该过程具有高达95%以上的期望氯化蔗糖衍生物，包括TGS的高回收率。
• Method for lowering serum glucose
  申请人：GelTex Pharmaceutical, Inc.

  公开号：US20020187121A1

  公开（公告）日：2002-12-12

  A method for treating hyperglycemia and/or reducing serum glucose levels in a patient that includes administering to the patient a therapeutically effective amount of an amine polymer is disclosed. In one embodiment, the amine polymer is aliphatic. Examples of polymers useful in an embodiment of the invention include sevelamer hydrogen chloride and colesevelam. The invention includes the use of amine polymers such as a cross-linked polymer characterized by a repeat unit having the formula: 1 and salts and copolymers thereof, where n is a positive integer and x is zero or an integer between 1 and about 4. Also described is a use, for the manufacture of a medicament, of a polymer that lowers serum glucose.

  本发明公开了一种治疗高血糖和/或降低患者血清葡萄糖水平的方法，包括向患者投予治疗有效量的胺基聚合物。在一种实施例中，胺基聚合物是脂肪族的。本发明的实施例中有用的聚合物的例子包括盐酸西韦拉酰胺和考来西韦。本发明包括使用胺基聚合物，例如交联聚合物，其特征在于重复单元具有公式1，以及其盐和共聚物，其中n是正整数，x为零或介于1和约4之间的整数。本发明还描述了一种用于制造药物的降低血清葡萄糖的聚合物的用途。
• PHYTOL DERIVED IMMUNOADJUVANTS AND THEIR USE IN VACCINE FORMULATIONS
  申请人：Ghosh K. Swapan

  公开号：US20060292163A1

  公开（公告）日：2006-12-28

  This invention relates to a novel immunoadjuvant, an adjuvant component, and vaccines containing the adjuvant component. The adjuvant includes phytol or a phytol derivative. The adjuvant component, when combined with a soluble or particulate antigen, provides a vaccine with an enhanced ability to induce both humoral and cytotoxic immune responses while displaying reduced toxicity and/or adverse side effects over vaccines that include the antigen but without the benefit of this adjuvant component.

  该发明涉及一种新型免疫佐剂、一种佐剂组分以及含有该佐剂组分的疫苗。该佐剂包括萜醇或萜醇衍生物。当该佐剂组分与可溶性或颗粒状抗原结合时，提供了一种疫苗，其具有增强诱导细胞免疫和体液免疫反应的能力，同时显示出比不含该佐剂组分的疫苗更低的毒性和/或不良副作用。