3-methoxy-6-methylene-3-(prop-2-ynyl)cyclohexa-1,4-diene | 1221432-82-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-methoxy-6-methylene-3-(prop-2-ynyl)cyclohexa-1,4-diene
• 英文别名: 3-Methoxy-6-methylidene-3-prop-2-ynylcyclohexa-1,4-diene
• CAS: 1221432-82-1
• 化学式: C₁₁H₁₂O
• 分子量: 160.216
• InChiKey: PHTUZUOIUSMKMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1,2-丙二烯三正丁基锡 、 4-甲氧基氯苄 在 四(三苯基膦)钯 、 四丁基氟化铵 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以82%的产率得到3-methoxy-6-methylene-3-(prop-2-ynyl)cyclohexa-1,4-diene
  参考文献：
  名称：

  Propargylic and Allenic Carbocycle Synthesis through Palladium-Catalyzed Dearomatization Reaction

  摘要：

  The dearomatization reaction of benzylic chlorides (1a-k), chloromethylnaphthalenes (1l-r), and naphthalene allyl chlorides (3a-d) with allenyltributyltin proceeded smoothly in the presence of Pd(PPh(3))(4) catalyst at room temperature to give the corresponding propargylated and/or allenylated dearomatization products (5, 5'; 6, 6'; and 7, respectively) in high to fair yields. The reaction of 1a-k proceeded smoothly in the presence of TBAF, whereas it was not necessary to use TBAF as an additive in the reactions of 1l-k and 3a-d. These reactions provided a new and efficient method for the synthesis of propargylic and allenic carbocycles.

  DOI：

  10.1021/jo100211d

文献信息

• Propargylic and Allenic Carbocycle Synthesis through Palladium-Catalyzed Dearomatization Reaction
  作者：Bo Peng、Xiujuan Feng、Xin Zhang、Sheng Zhang、Ming Bao

  DOI：10.1021/jo100211d

  日期：2010.4.16

  The dearomatization reaction of benzylic chlorides (1a-k), chloromethylnaphthalenes (1l-r), and naphthalene allyl chlorides (3a-d) with allenyltributyltin proceeded smoothly in the presence of Pd(PPh(3))(4) catalyst at room temperature to give the corresponding propargylated and/or allenylated dearomatization products (5, 5'; 6, 6'; and 7, respectively) in high to fair yields. The reaction of 1a-k proceeded smoothly in the presence of TBAF, whereas it was not necessary to use TBAF as an additive in the reactions of 1l-k and 3a-d. These reactions provided a new and efficient method for the synthesis of propargylic and allenic carbocycles.