benzophenone imine glycine isobutyl ester | 851428-37-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzophenone imine glycine isobutyl ester
• 英文别名: 2-Methylpropyl 2-(benzhydrylideneamino)acetate
• CAS: 851428-37-0
• 化学式: C₁₉H₂₁NO₂
• 分子量: 295.381
• InChiKey: GEZMFKAWXRXJHL-UHFFFAOYSA-N

物化性质

• 沸点：
  382.4±34.0 °C(Predicted)
• 密度：
  1.02±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-环戊烯甲醛 、 benzophenone imine glycine isobutyl ester 在 C₄₉H₄₈NO₄⁽¹⁺⁾*Br^(1-) 、 caesium carbonate 作用下， 反应 3.0h， 以39.6%的产率得到
  参考文献：
  名称：

  JP5829529

  摘要：

  公开号：
• 作为产物：
  描述：

  异丁醇 、 二苯亚甲基甘氨酸甲酯 在 tetrabutylammonium tricarbonylnitrosylferrate 作用下， 以 正己烷 为溶剂， 以84%的产率得到benzophenone imine glycine isobutyl ester
  参考文献：
  名称：

  Nucleophilic Iron Catalysis in Transesterifications: Scope and Limitations

  摘要：

  The ester bond is one of the most common structural motifs found in nature. Apart from the condensation between an acid and an alcohol, transesterifications represent another mechanistic alternative for the preparation of this compound class. The present paper summarizes our most recent investigations in this field, using nucleophilic iron complexes as catalysts for transesterifications under neutral conditions. This new type of metal catalyst complements the existing methodologies, which rely on Lewis acidic metal complexes. Investigations on scope and limitations, stereochemical course, and chemoselectivities will be presented.

  DOI：

  10.1021/jo1004636

文献信息

• Chiral phase-transfer catalyst and method for preparing alpha-amino acid by using the same
  申请人：Research Cooperation Foundation of Yeungnam University

  公开号：US10696621B2

  公开（公告）日：2020-06-30

  The present invention relates to a novel chiral phase-transfer catalyst, and a method for preparing an alpha-amino acid by using the same. According to the present invention, an alpha-amino acid of high optical purity could be synthesized in a high yield under an easy industrially applicable reaction condition by using a novel cinchona alkaloid compound as a chiral phase-transfer catalyst, and thus the present invention can be used as a key technique of the asymmetric alpha-amino acid synthesis and preparation field.

  本发明涉及一种新型手性相转移催化剂，以及使用该催化剂制备α-氨基酸的方法。根据本发明，使用一种新型金鸡纳生物碱化合物作为手性相转移催化剂，可以在易于工业化应用的反应条件下，高产率合成高光学纯度的α-氨基酸，因此本发明可作为不对称α-氨基酸合成和制备领域的一项关键技术。
• GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1812383A1

  公开（公告）日：2007-08-01
• NOVEL CHIRAL PHASE-TRANSFER CATALYST, AND METHOD FOR PREPARING A-AMINO ACID BY USING SAME
  申请人：Research Cooperation Foundation of Yeungnam University

  公开号：US20190292133A1

  公开（公告）日：2019-09-26

  The present invention relates to a novel chiral phase-transfer catalyst, and a method for preparing an alpha-amino acid by using the same. According to the present invention, an alpha-amino acid of high optical purity could be synthesized in a high yield under an easy industrially applicable reaction condition by using a novel cinchona alkaloid compound as a chiral phase-transfer catalyst, and thus the present invention can be used as a key technique of the asymmetric alpha-amino acid synthesis and preparation field.
• [EN] GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF<br/>[FR] COMPOSES INHIBITEURS DE LA PHOSPHORYLASE DU GLYCOGENE ET COMPOSITIONS PHARMACEUTIQUES LES COMPRENANT
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2006052722A1

  公开（公告）日：2006-05-18

  [EN] The invention relates to glycogen phosphorylase inhibitor compounds, pharmaceutical compositions of these compounds, methods of treatment using the pharmaceutical compositions to treat diabetes, conditions associated with diabetes, and/or tissue ischemia, including myocardial ischemia, and processes for making the compounds.
  [FR] L'invention concerne des composés inhibiteurs de la phosphorylase de glycogène, des compositions pharmaceutiques contenant lesdits composés, des méthodes de traitement utilisées pour traiter le diabète, des états pathologiques associés au diabète et/ou à l'ischémie des tissus, notamment l'ischémie myocardique, et des procédés pour fabriquer les composés de l'invention.
• Nucleophilic Iron Catalysis in Transesterifications: Scope and Limitations
  作者：Silja Magens、Bernd Plietker

  DOI：10.1021/jo1004636

  日期：2010.6.4

  The ester bond is one of the most common structural motifs found in nature. Apart from the condensation between an acid and an alcohol, transesterifications represent another mechanistic alternative for the preparation of this compound class. The present paper summarizes our most recent investigations in this field, using nucleophilic iron complexes as catalysts for transesterifications under neutral conditions. This new type of metal catalyst complements the existing methodologies, which rely on Lewis acidic metal complexes. Investigations on scope and limitations, stereochemical course, and chemoselectivities will be presented.