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Bis(2,2-dichlor-vinyl)keton | 5780-52-9

中文名称
——
中文别名
——
英文名称
Bis(2,2-dichlor-vinyl)keton
英文别名
1,1,5,5-Tetrachloropenta-1,4-dien-3-one
Bis(2,2-dichlor-vinyl)keton化学式
CAS
5780-52-9
化学式
C5H2Cl4O
mdl
——
分子量
219.882
InChiKey
POYHRXUCNTYVBV-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    3.4
  • 重原子数:
    10
  • 可旋转键数:
    2
  • 环数:
    0.0
  • sp3杂化的碳原子比例:
    0.0
  • 拓扑面积:
    17.1
  • 氢给体数:
    0
  • 氢受体数:
    1

反应信息

点击查看最新优质反应信息

文献信息

  • [EN] SUBSTITUTED 3-AMINO-THIENO[2,3-b]PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AND PROCESSES FOR PREPARING AND THEIR USES<br/>[FR] COMPOSES AMIDE D'ACIDE 3-AMINO-THIENO[2,3-b]PYRIDINE-2-CARBOXYLIQUE SUBSTITUES ET PROCESSUS DE PREPARATION ET D'UTILISATION DE CES COMPOSES
    申请人:BOEHRINGER INGELHEIM PHARMA
    公开号:WO2003103661A1
    公开(公告)日:2003-12-18
    Disclosed are compounds of formula (I), wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
    公开的是式(I)的化合物,其中R1和R2如本文所定义,这些化合物可用作IκB激酶(IKK)复合物激酶活性的抑制剂。因此,这些化合物在治疗IKK介导的疾病,包括自身免疫疾病、炎症性疾病和癌症方面是有用的。还公开了包含这些化合物的药物组合物以及制备这些化合物的方法。
  • 2,4,6-Tris(dialkylamino)pyrylium salts and related systems, synthesis and reaction behaviour
    作者:Werner Schroth、Roland Spitzner、Erich Kleinpeter
    DOI:10.1016/s0040-4039(00)80583-3
    日期:——
    multi-step route starting with 1,1,5,5-tetrachloro-penta-1,4-dien-3-one (). The tris(dialkylamino)-substituted , undergo electrophilic substitution. They are better represented as polymethine-like systems. The 2,6-bis(dialkylamino)-substituted , display a significantly increased donor-reactivity at the carbonyl-oxygen.
    2,4,6-三(二烷基氨基)吡喃鎓盐和2,6-二(二烷基氨基)-2H-吡喃-4-酮以及它们的硫代类似物,已制备了通过启动1,1,5-多步途径,5-四氯戊-1,4-二烯-3-酮()。(二烷基氨基) -取代的三,经历亲电取代。它们可以更好地表示为类似聚次甲基的系统。2,6-双(二烷基氨基)-取代的,在羰基氧上显示出显着增加的供体反应性。
  • Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
    申请人:Cywin L. Charles
    公开号:US20050288285A1
    公开(公告)日:2005-12-29
    Disclosed are compounds of formula (I): wherein R 1 and R 2 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
    本发明涉及化合物(I)的公开,其中R1和R2在此定义,这些化合物可用作IκB激酶(IKK)复合物的激酶活性抑制剂。因此,这些化合物可用于治疗由IKK介导的疾病,包括自身免疫性疾病、炎症性疾病和癌症。还公开了包含这些化合物的药物组合物和制备这些化合物的过程。
  • Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
    申请人:Boehringer Ingelheim Pharmaceuticals, Inc.
    公开号:US20040053957A1
    公开(公告)日:2004-03-18
    Disclosed are compounds of formula (I): 1 wherein R 1 and R 2 are defined herein, which are useful as inhibitors of the kinase activity of the I&kgr;B kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
    本发明公开了式(I)的化合物:其中R1和R2在此定义,这些化合物可用作IκB激酶(IKK)复合物的激酶活性抑制剂。因此,这些化合物可用于治疗IKK介导的疾病,包括自身免疫性疾病、炎症性疾病和癌症。本发明还公开了包含这些化合物的制药组合物和制备这些化合物的过程。
  • 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amides
    申请人:Boehringer Ingelheim Pharmaceuticals, Inc.
    公开号:EP2008654A1
    公开(公告)日:2008-12-31
    Disclosed are compounds of formula (I): wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
    所公开的是式 (I) 化合物: 其中 R1 和 R2 在此定义,可用作 IκB 激酶(IKK)复合物激酶活性的抑制剂。因此,这些化合物可用于治疗 IKK 介导的疾病,包括自身免疫性疾病、炎症性疾病和癌症。此外,还公开了包含这些化合物的药物组合物以及制备这些化合物的工艺。
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