1-phenyl-3-(2,4,6-trimethoxyphenyl)propan-1-one | 1422577-96-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1-phenyl-3-(2,4,6-trimethoxyphenyl)propan-1-one
• 英文别名: 1-Phenyl-3-(2,4,6-trimethoxyphenyl)propan-1-one
• CAS: 1422577-96-5
• 化学式: C₁₈H₂₀O₄
• 分子量: 300.354
• InChiKey: SHAMDWAIZBSMNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,4,6-三甲氧基苯甲醛 在 sodium tetrahydroborate 、 cerium(III) chloride heptahydrate 作用下， 以 甲醇 、 氯苯 为溶剂， 反应 1.0h， 生成 1-phenyl-3-(2,4,6-trimethoxyphenyl)propan-1-one
  参考文献：
  名称：

  嵌入氢氧化锡的蒙脱石催化的碳正离子形成烯醇硅与醇的前所未有的烷基化反应

  摘要：

  固体酸，氢氧化锡包埋的蒙脱石可催化各种烯醇硅与伯，仲和叔苄醇以及仲烯丙基醇的空前烷基化。Sn-Mont的酸催化作用不仅高于其他离子交换的蒙脱土（M-Mont； M = H，Ti，Fe和Al），而且高于典型的均相酸催化剂（如BF）3 ·OEt 2，TMSOTf和TfOH。

  DOI：

  10.1016/j.tetlet.2017.03.073

文献信息

• Methanol as a hydrogen source: room-temperature highly-selective transfer hydrogenation of α,β-unsaturated ketones
  作者：Nidhi Garg、Hari Prasaad Somasundharam、Pardeep Dahiya、Basker Sundararaju

  DOI：10.1039/d2cc03597a

  日期：——

  The described system offers an ideal, user-friendly protocol for the chemoselective homogeneous hydrogenation of α,β-unsaturated ketones at room temperature using methanol as a liquid organic hydrogen carrier. Excellent yields were achieved with an in situ-prepared phosphine-free Cp*Ir(III)/bipyridonate complex. Chemoselective reduction with other reducible functionalities and late-stage functionalization

  所描述的系统为使用甲醇作为液态有机氢载体在室温下对α、β-不饱和酮进行化学选择性均相氢化提供了一种理想的、用户友好的协议。使用原位制备的无膦Cp*Ir( III )/联吡啶络合物获得了优异的产率。还探索了具有其他可还原功能和后期功能化的化学选择性还原。
• Heterobimetallic Pd–Sn Catalysis: Michael Addition Reaction with C-, N-, O-, and S-Nucleophiles and in Situ Diagnostics
  作者：Debjit Das、Sanjay Pratihar、Sujit Roy

  DOI：10.1021/jo302643v

  日期：2013.3.15

  An efficient Michael addition reaction of differently substituted enones with carbon, sulfur, oxygen, and nitrogen nucleophiles has been achieved by a new heterobimetallic "Pd-Sn" catalyst system. The nature of the catalytically relevant species and their interactions with the enone moiety has been examined by spectroscopy. The effect of ligand and the coordination mode of enone with "Pd-Sn" heterobimetallic system have been investigated by kinetics and DFT studies. A straightforward application of this methodology is shown in the synthesis of 1,4-oxathiepane core.
• Unprecedented alkylation of silicon enolates with alcohols via carbenium ion formations catalyzed by tin hydroxide-embedded montmorillonite
  作者：Michael Andreas Tandiary、Masashi Asano、Taiki Hattori、Satoshi Takehira、Yoichi Masui、Makoto Onaka

  DOI：10.1016/j.tetlet.2017.03.073

  日期：2017.5

  The solid acid, tin hydroxide-embedded montmorillonite, catalyzes the unprecedented alkylation of various silicon enolates with primary, secondary and tertiary benzylic alcohols as well as secondary allylic alcohols. The acid catalysis of Sn-Mont was not only higher than that of the other ion-exchanged montmorillonites (M-Mont; M = H, Ti, Fe and Al), but also higher than that of the typical homogeneous

  固体酸，氢氧化锡包埋的蒙脱石可催化各种烯醇硅与伯，仲和叔苄醇以及仲烯丙基醇的空前烷基化。Sn-Mont的酸催化作用不仅高于其他离子交换的蒙脱土（M-Mont； M = H，Ti，Fe和Al），而且高于典型的均相酸催化剂（如BF）3 ·OEt 2，TMSOTf和TfOH。