2-Phenyl-5-chlorbenzimidazolin-3-on | 28561-70-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-Phenyl-5-chlorbenzimidazolin-3-on
• 英文别名: 4-Chlor-2-phenyl-indazolin-3-on；5-Chlor-2-phenyl-indazolon；5-Chlor-3-oxo-2-phenyl-2,3-dihydro-1H-indazol；5-chloro-2-phenyl-1,2-dihydro-indazol-3-one；5-Chlor-2-phenyl-1,2-dihydro-indazol-3-on；5-chloro-2-phenyl-1H-indazol-3-one
• CAS: 28561-70-8
• 化学式: C₁₃H₉ClN₂O
• 分子量: 244.68
• InChiKey: NYNJJZHWPVFBQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Phenyl-5-chlorbenzimidazolin-3-on 、 alkaline earth salt of/the/ methylsulfuric acid 生成 3,5-dichloro-2-phenylazo-benzoic acid
  参考文献：
  名称：

  Age-Related Changes in Protein Oxidation and Proteolysis in Mammalian Cells

  摘要：

  Reactive oxygen species generated as by-products of oxidative metabolism, or from environmental sources, frequently damage cellular macromolecules. Proteins are recognized as major targets of oxidative modification, and the accumulation of oxidized proteins is a characteristic feature of aging cells. An increase in the amount of oxidized proteins has been reported in many experimental aging models, as measured by the level of intracellular protein carbonyls or dityrosine, or by the accumulation of protein-containing pigments such as lipofuscin and ceroid bodies. In younger individuals, moderately oxidized soluble cell proteins appear to be selectively recognized and rapidly degraded by the proteasome. An age-related accumulation of oxidized proteins could, therefore, be a result of declining activity of the proteasome. Previous research to investigate the notion of an age-related decline in the content and/or activity of the proteasome has generated contradictory results. The latest evidence, including our own recent findings, indicates that proteasome activity does, indeed, decline during aging as the enzyme complex is progressively inhibited by oxidized and cross-linked protein aggregates. We propose that cellular aging involves both an increase in (mitochondrial) oxidant production and a progressive decline in proteasome activity. Eventually so much proteasome is inactivated that oxidized proteins begin to accumulate rapidly and contribute to cellular dysfunction and senescence.

  DOI：

  10.1093/gerona/56.11.b459
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 吡啶 、 三氯氧磷 作用下， 生成 2-Phenyl-5-chlorbenzimidazolin-3-on
  参考文献：
  名称：

  Freundler, Bulletin de la Societe Chimique de France, 1911, vol. <4> 9, p. 738

  摘要：

  DOI：

文献信息

• Horiie, Nippon Kagaku Zasshi, 1959, vol. 80, p. 1038,1039
  作者：Horiie

  DOI：——

  日期：——
• Freundler, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1909, vol. 149, p. 1136
  作者：Freundler

  DOI：——

  日期：——
• Freundler, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1906, vol. 142, p. 1154
  作者：Freundler

  DOI：——

  日期：——
• THE REACTION OF AZOBENZENE AND CARBON MONOXIDE
  作者：Shunsuke Murahashi、Shigeki Horiie

  DOI：10.1021/ja01599a079

  日期：1956.9