2-[(2-bromopropanoyl)oxy]ethyl 2-bromopropanoate | 5468-93-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[(2-bromopropanoyl)oxy]ethyl 2-bromopropanoate
• 英文别名: 2-(2-Bromopropanoyloxy)ethyl 2-bromopropanoate
• CAS: 5468-93-9；200192-34-3
• 化学式: C₈H₁₂Br₂O₄
• 分子量: 331.989
• InChiKey: OBNPDQQJYLNJPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  potassium ethyl xanthogenate 、 2-[(2-bromopropanoyl)oxy]ethyl 2-bromopropanoate 以 丙酮 为溶剂， 反应 24.0h， 以55%的产率得到2,2-bis(((2-((ethoxycarbonothioyl)thio)propanoyl)oxy)methyl)propane -1,3-diyl bis(2-((ethoxycarbonothioyl)thio)propanoate)
  参考文献：
  名称：

  通过耐氧的光酶RAFT聚合，以多种结构实现非共轭单体的超高分子量。

  摘要：

  获得可定义的超高分子量（UHMW）聚合物是可逆失活自由基聚合领域的不懈追求。已经成功地开发了合成方案以仅从共轭单体获得具有低分散性的UHMW，而未共轭单体的聚合没有提供相同水平的控制。本文利用耐氧光酶R​​AFT（可逆加成-断裂链转移）聚合技术解决了10°C下非共轭单体的这一难题，从而能够以接近定量的转化率轻松合成定义明确，线性和星形的聚合物，这是前所未有的超高分子量和低分散性。对组成，MW和架构的控制非常精细，并且操作简便，条件温和，环境友好，

  DOI：

  10.1002/anie.202010722
• 作为产物：
  描述：

  乙二醇 、 2-溴丙酰溴 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 生成 2-[(2-bromopropanoyl)oxy]ethyl 2-bromopropanoate
  参考文献：
  名称：

  通过耐氧的光酶RAFT聚合，以多种结构实现非共轭单体的超高分子量。

  摘要：

  获得可定义的超高分子量（UHMW）聚合物是可逆失活自由基聚合领域的不懈追求。已经成功地开发了合成方案以仅从共轭单体获得具有低分散性的UHMW，而未共轭单体的聚合没有提供相同水平的控制。本文利用耐氧光酶R​​AFT（可逆加成-断裂链转移）聚合技术解决了10°C下非共轭单体的这一难题，从而能够以接近定量的转化率轻松合成定义明确，线性和星形的聚合物，这是前所未有的超高分子量和低分散性。对组成，MW和架构的控制非常精细，并且操作简便，条件温和，环境友好，

  DOI：

  10.1002/anie.202010722

文献信息

• AMINO ACID DERIVATIVES AND ABSORBABLE POLYMERS THEREFROM
  申请人：Bezwada Biomedical, LLC

  公开号：US20160257643A1

  公开（公告）日：2016-09-08

  The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, stents, stent coatings, highly porous foams, reticulated foams, wound care, cardiovascular applications, orthopedic devices, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers should have a controlled degradation profile.

  本发明涉及发现一类新的可水解氨基酸衍生物和可吸收聚酯酰胺、聚酰胺、聚环氧化物、聚脲和由此制备的聚氨酯。由此产生的可吸收聚合物可用于药物输送、组织工程、组织粘合剂、粘附防止、骨蜡配方、医疗器械涂层、支架、支架涂层、高度多孔泡沫、网状泡沫、伤口护理、心血管应用、骨科器械、表面改性剂和其他可植入医疗器械。此外，这些可吸收聚合物应具有受控的降解特性。
• Transition metal compound, polymerization-initiator system comprising the same, and process for producing polymer
  申请人：Uemura Makoto

  公开号：US20070270521A1

  公开（公告）日：2007-11-22

  A transition metal compound represented by the formula, [(CpR 1 m )(CO) 2 M 1 ][M 2 (CO) 2 (CpR 2 n )], wherein Cp is a cyclopentadienyl ring, R 1 and R 2 are independently of each other a hydrocarbyl group having 1 to 20 carbon atoms, and each of at least one R 1 and at least one R 2 is a hydrocarbyl group having 5 to 20 carbon atoms, m and n are independently of each other an integer of 1 to 5, and M 1 and M 2 are independently of each other a transition metal atom of the group 8 in the periodic table of elements; a polymerization-initiator system comprising said transition metal compound; and a process for producing a polymer in the presence of the polymerization-initiator system.

  一个由该公式表示的过渡金属化合物，[(CpR1m)(CO)2M1][M2(CO)2(CpR2n)]，其中Cp是一个环戊二烯环，R1和R2是独立的烃基团，含有1至20个碳原子，至少一个R1和至少一个R2是含有5至20个碳原子的烃基团，m和n是独立的1至5的整数，M1和M2是元素周期表中8族的过渡金属原子；包括所述过渡金属化合物的聚合物化引发剂系统；以及在聚合物化引发剂系统存在的情况下生产聚合物的过程。
• AMINO ACID DERIVATIVES AND ABSORABLE POLYMERS THEREFROM
  申请人：Bezwada Rao S.

  公开号：US20120208896A1

  公开（公告）日：2012-08-16

  The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, stents, stent coatings, highly porous foams, reticulated foams, wound care, cardiovascular applications, orthopedic devices, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers should have a controlled degradation profile.

  本发明涉及一种新类水解性氨基酸衍生物和可吸收聚酯酰胺、聚酰胺、聚环氧化物、聚脲和由此制备的聚氨酯。所得的可吸收聚合物可用于药物输送、组织工程、组织粘合剂、粘附预防、骨蜡配方、医疗器械涂层、支架、支架涂层、高度多孔泡沫、网状泡沫、伤口护理、心血管应用、骨科器械、表面改性剂和其他可植入医疗器械。此外，这些可吸收聚合物应具有受控降解特性。
• PROCESS FOR PRODUCTION OF POLYMERS WITH IRON COMPLEX CATALYST
  申请人：Kai Hidetomo

  公开号：US20110105703A1

  公开（公告）日：2011-05-05

  The invention relates to a novel iron complex bearing a cyclic amine as ligand; and a process for the production of polymers by polymerizing a radical-polymerizable monomer in the presence of the iron complex and a radical generator. The invention aims at providing a process by which a polymer having a chemically convertible functional group at the end can be produced from a radical-polymerizable monomer and which permits the production of a block copolymer and a process for recovering, after polymerization, an iron complex into a solvent at a high recovery ratio. The aim can be solved by providing a novel iron complex, a process for producing a polymer in the presence of a radical polymerization initiator by using the iron complex as the polymerization catalyst, a process for the production of a block copolymer which is subsequent to the polymerization for producing the above polymer, and a process for recovering the iron complex easily and simply. The invention provides an iron complex useful in producing a polymer by polymerizing a radical-polymerizable monomer; and a process for the production of polymers with the iron catalyst.

  该发明涉及一种具有环胺作为配体的新型铁配合物；以及通过在铁配合物和自由基发生剂的存在下聚合自由基可聚合单体来生产聚合物的方法。该发明旨在提供一种通过在自由基可聚合单体中生产具有化学可转化官能团末端的聚合物的方法，并且允许生产嵌段共聚物以及在聚合后将铁配合物以高回收率回收到溶剂中的方法。该目的可以通过提供一种新型铁配合物、在自由基聚合引发剂的存在下使用铁配合物作为聚合催化剂生产聚合物的方法、在上述聚合物生产后用于生产嵌段共聚物的方法以及轻松简便地回收铁配合物的方法来实现。该发明提供了一种有用的铁配合物，用于通过聚合自由基可聚合单体来生产聚合物；以及使用铁催化剂生产聚合物的方法。
• [EN] PREPARATION OF NOVEL FLUOROCOMPOUNDS, METHODS OF PREPARATION AND COMPOSITIONS MADE THEREFROM<br/>[FR] PRÉPARATION DE NOUVEAUX COMPOSÉS FLUORÉS, PROCÉDÉS DE PRÉPARATION ET COMPOSITIONS FABRIQUÉES À PARTIR DE CEUX-CI
  申请人：HENKEL CORP

  公开号：WO2013055572A1

  公开（公告）日：2013-04-18

  Novel fluorinated compounds, their method of preparation and use are disclosed, as well as the incorporation of new and old fluorinated compounds in controlled radical polymerization processes to efficiently produce polymer compositions with unique and enhanced properties. Various cure mechanisms and types of end-uses are disclosed.

  揭示了新型氟化合物的制备方法和用途，以及在受控自由基聚合过程中将新型和旧型氟化合物合并，以高效生产具有独特和增强性能的聚合物组合物。还揭示了各种固化机制和端点用途类型。