(4-Fluorophenyl)(3-hydroxyphenyl)methanone | 62810-47-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-Fluorophenyl)(3-hydroxyphenyl)methanone
• 英文别名: (4-fluorophenyl)-(3-hydroxyphenyl)methanone
• CAS: 62810-47-3
• 化学式: C₁₃H₉FO₂
• 分子量: 216.212
• InChiKey: AVTZOMBANNWKGQ-UHFFFAOYSA-N

物化性质

• 熔点：
  105°C
• 沸点：
  380.6±27.0 °C(Predicted)
• 密度：
  1.270±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (4-Fluorophenyl)(3-hydroxyphenyl)methanone 在 水 、 sodium carbonate 、 potassium carbonate 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 2-(3-(p-Fluorobenzoyl)phenoxy)propionic acid
  参考文献：
  名称：

  Astoin; Lepage; Fromantin, European Journal of Medicinal Chemistry, 1980, vol. 15, # 5, p. 457 - 462

  摘要：

  DOI：
• 作为产物：
  描述：

  氟苯 、 间甲氧基苯甲酰氯 在 三氯化铝 作用下， 以43%的产率得到(4-Fluorophenyl)(3-hydroxyphenyl)methanone
  参考文献：
  名称：

  Astoin; Lepage; Fromantin, European Journal of Medicinal Chemistry, 1980, vol. 15, # 5, p. 457 - 462

  摘要：

  DOI：

文献信息

• Cyclic poly(aryl ether) oligomers, a process for preparation thereof, and polymerization of cyclic poly (aryl ether) oligomers
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0413257A2

  公开（公告）日：1991-02-20

  The present invention is directed to cyclic poly(aryl ether) oligomers and mixtures thereof, and methods for the preparation thereof in a highly dilute reaction medium under reaction conditions favorable for ring closure at low degrees of polymerization. These oligomers are represented by the general formula where each Y is divalent oxygen or divalent sulfur, each Ar is an aromatic diradical which comprises one or more C₆ to C₂₀ arylene groups and has at least one electron withdrawing group attached to an aromatic ring, and n is an integer from 1 to 20 with the proviso that for integer values of n equal to 1 or 2 all linkages between independent aromatic rings comprise at least one atom. The present invention includes a process for the preparation of poly(aryl ethers) from cyclic poly(aryl ether) oligomers. These low melt viscosity cyclic oligomers undergo ring opening and chain extension upon heating in the presence of a catalyst, forming high molecular weight linear polymers with no coproduct formation. Finished thermoplastic parts and composites may be prepared using this technology with processing techniques normally restricted to thermosetting monomers.

  本发明涉及环状聚芳基醚低聚物及其混合物，以及在高度稀释的反应介质中，在有利于低聚合度下闭环的反应条件下制备它们的方法。这些低聚物通式如下 其中，每个 Y 是二价氧或二价硫，每个 Ar 是芳香族二元环，包括一个或多个 C₆ 至 C₂₀ 芳烯基团，并至少有一个取电子基团连接到芳香环上，n 是 1 至 20 的整数，但 n 的整数值等于 1 或 2 时，独立芳香环之间的所有连接至少包括一个原子。 本发明包括一种从环状聚芳基醚低聚物制备聚芳基醚的工艺。这些低熔融粘度的环状低聚物在催化剂存在下加热时会发生开环和链延伸，形成高分子量的线性聚合物，且不会产生副产品。使用这种技术可以制备热塑性塑料零件和复合材料成品，其加工技术通常仅限于热固性单体。
• New Azolidinediones as Inhibitors of Protein Tyrosine Phosphatase 1B with Antihyperglycemic Properties
  作者：Michael S. Malamas、Janet Sredy、Iwan Gunawan、Brenda Mihan、Diane R. Sawicki、Laura Seestaller、Donald Sullivan、Brenda R. Flam

  DOI：10.1021/jm990476x

  日期：2000.3.1

  Insulin resistance in the liver and peripheral tissues together with a pancreatic cell defect are the common causes of type 2 diabetes. It is now appreciated that insulin resistance can result from a defect in the insulin receptor signaling system, at a site post binding of insulin to its receptor. Protein tyrosine phosphatases (PTPases) have been shown to be negative regulators of the insulin receptor. Inhibiton of PTPase may be an effective method in the treatment of type 2 diabetes. A series of azolidinediones has been prepared as protein tyrosine phosphatase 1B (PTP1B) inhibitors. Several compounds were potent inhibitors against the recombinant rat and human PTP1B enzymes with submicromolar IC50 values. Elongated spacers between the azolidinedione moiety and the central aromatic portion of the molecule as well as hydrophobic groups at the vicinity of this aromatic region were very important to the inhibitory activity. Oxadiazolidinediones 87 and 88 and the corresponding acetic acid analogues 119 and 120 were the best h-PTP1B inhibitors with IC50 values in the range of 0.12-0.3 mu M. Several compounds normalized plasma glucose and insulin levels in the ob/ob and db/db diabetic mouse models.
• DD125658
  申请人：——

  公开号：——

  公开（公告）日：——
• ASTOIN J.; LEPAGE F.; FROMANTIN J.-P.; POISSON M., EUR. J. MED. CHEM.-CHIM. THER., 1980, 15, NO 5, 457-462
  作者：ASTOIN J.、 LEPAGE F.、 FROMANTIN J.-P.、 POISSON M.

  DOI：——

  日期：——
• US5264520A
  申请人：——

  公开号：US5264520A

  公开（公告）日：1993-11-23