2,5-dihydro-3,4-dimethylthiophene | 98610-46-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢噻吩类
• 英文名称: 2,5-dihydro-3,4-dimethylthiophene
• 英文别名: 3,4-Me2DHT；3,4-Dimethyl-2,5-dihidrothiophene；3,4-dimethyl-2,5-dihydrothiophene
• CAS: 98610-46-9
• 化学式: C₆H₁₀S
• 分子量: 114.211
• InChiKey: FVJYABFEMJVLGH-UHFFFAOYSA-N

物化性质

• 沸点：
  154.8±29.0 °C(Predicted)
• 密度：
  0.972±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
• 保留指数：
  1213

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,5-dihydro-3,4-dimethylthiophene 在 sodium hydride 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 1-methylthio-2,3-dimethylbuta-1,3-diene
  参考文献：
  名称：

  Pettett, Michael G.; Holmes, Andrew B., Journal of the Chemical Society. Perkin transactions I, 1985, p. 1161 - 1166

  摘要：

  DOI：
• 作为产物：
  描述：

  3,4-dimethyl-3-sulfolene 在 diisobutylaluminum hydride 作用下， 以 乙二醇二甲醚 、 甲苯 为溶剂， 反应 24.0h， 以47%的产率得到2,5-dihydro-3,4-dimethylthiophene
  参考文献：
  名称：

  Pettett, Michael G.; Holmes, Andrew B., Journal of the Chemical Society. Perkin transactions I, 1985, p. 1161 - 1166

  摘要：

  DOI：

文献信息

• FUNGICIDAL PYRANONES AND OXAZINONES
  申请人：STEVENSON THOMAS MARTIN

  公开号：US20120329787A1

  公开（公告）日：2012-12-27

  Disclosed are compounds of Formula 1, including all geometric and stereoisomers, tautomers, N-oxides, and salts thereof, wherein Q, Z, R 2 , R 3 and R 4 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.

  本文披露了Formula 1的化合物，包括所有的几何和立体异构体、互变异构体、N-氧化物和盐，其中Q、Z、R2、R3和R4如披露中所定义。还披露了含有Formula 1化合物的组合物，以及控制由真菌病原体引起的植物疾病的方法，包括施用本发明的化合物或组合物的有效量。
• FUSED RING PYRIDINE COMPOUND
  申请人：Astellas Pharma Inc.

  公开号：US20130143874A1

  公开（公告）日：2013-06-06

  [Problem] To provide a compound useful as a novel agent which is excellent in preventing and/or treating cannabinoid receptor type 2-related diseases, based on agonist action on a cannabinoid receptor type 2 [Means for Solution] The present inventors conducted thorough investigation regarding compounds having agonist action on a cannabinoid receptor type 2. They confirmed that the fused ring pyridine compound of the present invention has excellent agonist action on the cannabinoid receptor type 2, thereby completing the present invention. The fused ring pyridine compound of the present invention has agonist action on the cannabinoid receptor type 2, and can be used as an agent for preventing and/or treating cannabinoid receptor type 2-related diseases, for example, inflammatory diseases and pain.

  [问题] 提供一种化合物，作为一种新型药剂，具有优异的防治大麻素受体类型2相关疾病的作用，基于对大麻素受体类型2的激动剂作用[解决方案] 本发明的发明人对具有大麻素受体类型2激动剂作用的化合物进行了彻底调查。他们确认本发明的融合环吡啶化合物在大麻素受体类型2上具有优异的激动剂作用，从而完成了本发明。本发明的融合环吡啶化合物在大麻素受体类型2上具有激动剂作用，可用作预防和/或治疗大麻素受体类型2相关疾病的药剂，例如炎症性疾病和疼痛。
• BENZAMIDES AND RELATED INHIBITORS OF FACTOR XA
  申请人：Zhu Bing-Yan

  公开号：US20090131411A1

  公开（公告）日：2009-05-21

  Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.

  本发明涉及一种新型苯甲酰胺类化合物，包括其药学上可接受的异构体，盐，水合物，溶剂合物和前药衍生物，具有对哺乳动物因子Xa的活性。本发明还涉及含有这种化合物的组合物。这些化合物和组合物在体内或体外用于预防或治疗凝血障碍。
• Pyrimidine Derivative Condensed with a Non-Aromatic Ring
  申请人：Yonetoku Yasuhiro

  公开号：US20080070896A1

  公开（公告）日：2008-03-20

  There are provided new pyrimidine derivatives condensed with a non-aromatic ring selected from dihydrothiophene, dihydrofuran, cycloalkane moiety, and the like or pharmaceutically acceptable salts thereof; and a pharmaceutical composition comprising said compound as an active ingredient. These compounds exhibit excellent promoting activity on insulin secretion and activity against hyperglycemia. Hence, the pharmaceutical compositions comprising such compounds as active ingredients, based on these actions, are useful for treating and/or preventing insulin-dependent diabetes (type 1 diabetes), non-insulin-dependent diabetes (type 2 diabetes), insulin-resistant diseases, obesity, and the like.

  提供了一些新的嘧啶衍生物，其与二氢噻吩、二氢呋喃、环烷基等非芳香环结构缩合，或其药学上可接受的盐缩合；以及一种含有该化合物作为活性成分的制药组合物。这些化合物表现出对胰岛素分泌的促进活性和对高血糖的活性。因此，基于这些作用，包含这些化合物作为活性成分的制药组合物可用于治疗和/或预防胰岛素依赖性糖尿病（1型糖尿病）、非胰岛素依赖性糖尿病（2型糖尿病）、胰岛素抵抗性疾病、肥胖症等。
• OXOPYRAZINE DERIVATIVE AND HERBICIDE
  申请人：Tamai Ryuji

  公开号：US20100197674A1

  公开（公告）日：2010-08-05

  The present invention is to provide an oxopyrazine derivative having an excellent herbicidal activity and besides exhibiting high safety for useful crops and the like, or a salt thereof, and a herbicide containing the same. The present invention relates to an oxopyrazine derivative represented by formula [I]: wherein X 1 represents an oxygen atom or a sulfur atom; X 2 represents CH or N(O) m ; m represents an integer of 0 or 1; R 1 represents a hydrogen atom, a C 1 -C 12 alkyl group and the like; R 2 represents a halogen atom, a cyano group and the like; R 3 is a hydroxyl group, a halogen atom and the like; A 1 represents C(R 4 R 5 ); A 2 represents C(R 6 R 7 ) or C═O; A 3 represents C(R 8 R 9 ); R 4 to R 9 represent a hydrogen atom or an alkyl group, or a salt thereof, and a herbicide containing these compounds.

  本发明提供了一种具有优异除草活性且对有用作物等具有高安全性的氧杂吡嗪衍生物或其盐，以及含有该衍生物的除草剂。本发明涉及一种由式[I]表示的氧杂吡嗪衍生物，其中X1代表氧原子或硫原子；X2代表CH或N(O)m；m代表0或1的整数；R1代表氢原子、C1-C12烷基等；R2代表卤素原子、氰基等；R3代表羟基、卤素原子等；A1代表C(R4R5)；A2代表C(R6R7)或C═O；A3代表C(R8R9)；R4到R9代表氢原子或烷基，或其盐，以及含有这些化合物的除草剂。