t-butoxypentachlorobenzene | 89752-05-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: t-butoxypentachlorobenzene
• 英文别名: 1-tert-Butoxy-2,3,4,5,6-pentachlorobenzene；1,2,3,4,5-pentachloro-6-[(2-methylpropan-2-yl)oxy]benzene
• CAS: 89752-05-6
• 化学式: C₁₀H₉Cl₅O
• 分子量: 322.446
• InChiKey: SWJXHYGKWGDBIA-UHFFFAOYSA-N

物化性质

• 熔点：
  40-42 °C
• 沸点：
  351.6±37.0 °C(Predicted)
• 密度：
  1.447±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  六氯苯 、 potassium tert-butylate 以 四氢呋喃 为溶剂， 反应 0.42h， 以67%的产率得到t-butoxypentachlorobenzene
  参考文献：
  名称：

  Polyhalogenoaromatic Compounds; 51¹. Substitution of Polychloro- and Polybromoaromatic Compounds by Potassiumt-Butoxide

  摘要：

  DOI：

  10.1055/s-1984-30721

文献信息

• ACTIVATED CYTOTOXIC COMPOUNDS FOR ATTACHMENT TO TARGETING MOLECULES FOR THE TREATMENT OF MAMMALIAN DISEASE CONDITIONS
  申请人：Fegley Glenn

  公开号：US20100022615A1

  公开（公告）日：2010-01-28

  Activated cytotoxic compounds are described for attachment to targeting molecules for the treatment of a mammalian disease condition which comprise, an activator, a spacer linker, a linker (e.g., self-immolative), and a cytotoxic drug selected from the group consisting of AMINO-SUBSTITUTED (E)-2,6-DIALKOXYSTYRYL 4-SUBSTITUTED BENZYLSULFONES, AMINO-AND-HYDROXY SUBSTITUTED STYRYLSULFONANILIDES, and SUBSTITUTED PHENOXY- AND PHENYLTHIO-STYRYLSULFONE DERIVATIVES. Activated cytotoxic compound attached to a targeting molecule are described wherein the targeting molecule is selected from the group consisting essentially of an antibody, a receptor, a ligand, a cytokine, a hormone, and a signal transduction molecule. The invention is further directed to a method of treatment of disease conditions.

  本发明涉及一种激活的细胞毒性化合物，用于附着于靶向分子治疗哺乳动物疾病状况，包括激活剂、间隔连接剂、连接剂（例如自解性连接剂）和从AMINO-SUBSTITUTED（E）-2,6-DIALKOXYSTYRYL 4-SUBSTITUTED BENZYLSULFONES、AMINO-AND-HYDROXY SUBSTITUTED STYRYLSULFONANILIDES和SUBSTITUTED PHENOXY-AND PHENYLTHIO-STYRYLSULFONE DERIVATIVES组成的细胞毒性药物。本发明还涉及附着于靶向分子的激活的细胞毒性化合物，其中靶向分子从抗体、受体、配体、细胞因子、激素和信号转导分子等组成的群体中选择。本发明进一步涉及一种治疗疾病状况的方法。
• BRADY, J. H.;WAKEFIELD, B. J., SYNTHESIS, BRD, 1984, N 1, 33-34
  作者：BRADY, J. H.、WAKEFIELD, B. J.

  DOI：——

  日期：——
• NOVEL PHOSPHOROUS (V)-BASED REAGENTS, PROCESSES FOR THE PREPARATION THEREOF, AND THEIR USE IN MAKING STEREO-DEFINED ORGANOPHOSHOROUS (V) COMPOUNDS
  申请人：Bristol-Myers Squibb Company

  公开号：US20190322694A1

  公开（公告）日：2019-10-24

  The present invention relates to novel phosphorous (V) (P(V)) reagents, methods for preparing thereof, and methods for preparing organophosphorous (V) compounds by using the novel reagents.
• US8273787B2
  申请人：——

  公开号：US8273787B2

  公开（公告）日：2012-09-25
• Polyhalogenoaromatic Compounds; 51¹. Substitution of Polychloro- and Polybromoaromatic Compounds by Potassium<i>t</i>-Butoxide
  作者：John. H. Brady、Basil J. Wakefield

  DOI：10.1055/s-1984-30721

  日期：——