1,2-Diazaazulen | 275-70-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1,2-Diazaazulen
• 英文别名: cycloheptapyrazole；Cyclohepta[c]pyrazole
• CAS: 275-70-7
• 化学式: C₈H₆N₂
• 分子量: 130.149
• InChiKey: UREWVVFRSGFOEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Method for the synthesis of tryptophan analogs in aqueous solvents at reduced temperatures
  申请人：California Institute of Technology

  公开号：US10752927B2

  公开（公告）日：2020-08-25

  The present disclosure provides methods for preparing tryptophans and tryptophan derivatives. The methods include: combining i) an indole substrate or azulene substrate, ii) a serine substrate, and iii) an engineered tryptophan synthase β-subunit (TrpB); and maintaining the resulting mixture under conditions sufficient to form the product compound. The engineered TrpB comprises a PLP binding loop mutation, a helix 1 mutation, a strand 7-8 mutation, or a combination thereof. New TrpB variants are also described.

  本公开提供了制备色氨酸和色氨酸衍生物的方法。这些方法包括：将 i) 吲哚底物或氮烯底物、ii) 丝氨酸底物和 iii) 经改造的色氨酸合酶 β-亚基（TrpB）结合在一起；并将所得混合物保持在足以形成产物化合物的条件下。改造的 TrpB 包括 PLP 结合环突变、螺旋 1 突变、链 7-8 突变或其组合。此外还描述了新的 TrpB 变体。
• INDENO 1,2-c]-, NAPHTHO 1,2-c]- AND BENZO 6,7]CYCLOHEPTA 1,2-c]PYRAZOLE DERIVATIVES
  申请人：BASF AKTIENGESELLSCHAFT

  公开号：EP1023063A1

  公开（公告）日：2000-08-02
• INDENO[1,2-c], NAPHTHO[1,2-c]- AND BENZO[6,7]CYCLOHEPTA[1,2-c]PYRAZOLE DERIVATIVES
  申请人：ABBOTT GmbH & Co. KG

  公开号：EP1023063B1

  公开（公告）日：2003-09-10
• IMPROVED METHOD FOR THE SYNTHESIS OF TRYPTOPHAN ANALOGS IN AQUEOUS SOLVENTS AT REDUCED TEMPERATURES
  申请人：California Institute of Technology

  公开号：EP3759227A1

  公开（公告）日：2021-01-06
• METHOD FOR THE SYNTHESIS OF TRYPTOPHAN ANALOGS IN AQUEOUS SOLVENTS AT REDUCED TEMPERATURES
  申请人：California Institute of Technology

  公开号：US20190271016A1

  公开（公告）日：2019-09-05

  The present disclosure provides methods for preparing tryptophans and tryptophan derivatives. The methods include: combining i) an indole substrate or azulene substrate, ii) a serine substrate, and iii) an engineered tryptophan synthase β-subunit (TrpB); and maintaining the resulting mixture under conditions sufficient to form the product compound. The engineered TrpB comprises a PLP binding loop mutation, a helix 1 mutation, a strand 7-8 mutation, or a combination thereof. New TrpB variants are also described.