N,5-diphenyl-1H-pyrazol-3-amine | 41443-37-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N,5-diphenyl-1H-pyrazol-3-amine
• 英文别名: N-(5-Phenyl-3-pyrazolyl)anilin；3-Anilino-5-phenyl-pyrazol
• CAS: 41443-37-2
• 化学式: C₁₅H₁₃N₃
• 分子量: 235.288
• InChiKey: KTQSZWIQENTBCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  40.7
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,5-diphenyl-1H-pyrazol-3-amine 在 硝酸 作用下， 生成 (2,4-dinitro-phenyl)-(4-nitro-5-phenyl-1(2)H-pyrazol-3-yl)-amine
  参考文献：
  名称：

  The Action of Hydroxylamine and Hydrazine on Acetylenic Thioamides

  摘要：

  DOI：

  10.1021/ja01284a048
• 作为产物：
  描述：

  (phenylethynyl)sodium 在 乙醚 、 肼 作用下， 反应 2.0h， 生成 N,5-diphenyl-1H-pyrazol-3-amine
  参考文献：
  名称：

  The Action of Hydroxylamine and Hydrazine on Acetylenic Thioamides

  摘要：

  DOI：

  10.1021/ja01284a048

文献信息

• Tetrabutylammonium Iodide Mediated Sulfenylation of Poly­substituted 1H-Pyrazol-5-amines with Arylsulfonyl Hydrazides
  作者：Bin Dai、Ping Liu、Jing He、Yueting Wei、Xuezhen Li

  DOI：10.1055/a-1592-6394

  日期：2022.1

  A TBAI-mediated sulfenylation of N,3-diaryl-1-arylsulfonyl-1H-pyrazol-5-amines with arylsulfonyl hydrazides has been established, and an expanded inventory of N,5-diaryl-4-(arylthio)-1H-pyrazol-3-amines was constructed through C–S bond formation and N–S bond breaking. Mechanistic investigations suggest thiosulfonate as a key intermediate in the sulfenylation, and the detosylation is promoted by the generated arylsulfinic acid. The method is characterized by simple operating conditions, broad substrate range as well as gram-scale reaction.

  通过TBAI介导的N,3-二芳基-1-芳磺酰基-1H-吡唑-5-胺与芳基磺酰肼的磺酰化反应已经建立，并通过C-S键形成和N-S键断裂构建了N,5-二芳基-4-(芳硫)-1H-吡唑-3-胺的扩展库存。机理研究表明硫代磺酸酯是磺酰化中的关键中间体，去磺酰作用由生成的芳基亚磺酸促进。该方法具有简单的操作条件、广泛的底物范围以及克级反应的特点。

• A facile synthesis of substituted 4,5,6,7-tetrahydropyrazolo[3,4-<i>d</i>]-pyrimidine and 1,2,3,4-tetrahydropyrazolo[1,5-<i>a</i>]triazine derivatives
  作者：J. N. Vishwakarma、M. Mofizuddin、H. Ila、H. Junjappa

  DOI：10.1002/jhet.5570250523

  日期：1988.9

  Cyclocondensation of 3(5)-alkylamino- and 3(5-arylaminopyrazoles 1a-c and 1d-e with formaldehyde and primary amines affords novel tetrahydropyrazolo[3,4-d]pyrimidines 2 and tetrahydropyrazolo[1,5-a]triazine derivatives 3 respectivley in good yields.

  3（5）-烷基氨基-和3（5-芳基氨基吡唑1a-c和1d-e与甲醛和伯胺的环缩合反应提供了新颖的四氢吡唑并[3,4- d ]嘧啶2和四氢吡唑并[1,5- a ]三嗪衍生物3pectelevley，高产。
• Synthesis of Aminopyrazolesfrom α- Oxoketene<i>O</i>,<i>N</i>-Acetals Using MontmorilloniteK-10/Ultrasound
  作者：Mara E. Braibante、Hugo T. Braibante、Juliano K. da Roza、Danielle M. Henriques、Luciana de Carvalho Tavares

  DOI：10.1055/s-2003-39398

  日期：——

  5(3)-Amino-3(5) phenylpyrazoles 3a-f have been conveniently prepared by condensation of α-oxoketene O,N-acetals 2a-g with hydrazine using montmorillonite K-10 as solid support under sonication.

  5(3)-Amino-3(5) phenylpyrazoles 3a-f 是以δ-氧代酮类 O,N-乙缩醛 2a-g 与肼在超声条件下用蒙脱石 K-10 作为固体支持物进行缩合而制备的。
• Synthesis of Amino Substituted Pyrazoles
  作者：Okram Mukherjee Singh、Mohammad Farooque Ahmed、Sarangthem Joychandra Singh、Sang-Gyeong Lee

  DOI：10.3184/030823407x209723

  日期：2007.4

  An efficient and convenient synthesis of substituted pyrazoles with aryl and heteroarylamino substituents attached to the C-3 and C-5 positions by the action of hydrazine hydrate on either ketene N,S-acetals or mixed N,N-aminals hydrate is reported.

  报告了通过水合肼对烯酮 N,S-乙醛或混合 N,N-氨基水合物的作用，高效、方便地合成在 C-3 和 C-5 位上带有芳基和杂芳基氨基取代基的取代吡唑的方法。
• Pyrazole Kinase Modulators And Methods Of Use
  申请人：Baik Tae-Gon

  公开号：US20070293507A1

  公开（公告）日：2007-12-20

  The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.

  本发明提供了用于调节蛋白激酶酶活性，以调节细胞活动（如增殖、分化、程序性细胞死亡、迁移和化学浸润）的化合物。本发明的化合物抑制、调节和/或调节激酶。使用这些化合物和制药组合物来治疗激酶依赖性疾病和状况也是本发明的一个方面。