8-oxa-bicyclo[3.2.1]oct-2-ene | 117065-62-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 8-oxa-bicyclo[3.2.1]oct-2-ene
• 英文别名: 8-Oxabicyclo[3.2.1]octa-2-ene；8-oxabicyclo[3.2.1]oct-2-ene
• CAS: 117065-62-0
• 化学式: C₇H₁₀O
• 分子量: 110.156
• InChiKey: YONJKKFOFGYRNM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2,3,4,4-tetrachloro-8-oxa-bicyclo[3.2.1]octa-2,6-diene 在 palladium on activated charcoal lithium aluminium tetrahydride 、 氢气 、 sodium 作用下， 以 四氢呋喃 、 乙醇 、 乙酸乙酯 为溶剂， 生成 8-oxa-bicyclo[3.2.1]oct-2-ene
  参考文献：
  名称：

  Asymmetric allylic oxidation of bridged-bicyclic alkenes using a copper-catalysed symmetrising–desymmetrising Kharasch–Sosnovsky reaction

  摘要：

  Enantioselective symmetrising-desymmetrising allylic oxidation of racemic bridged bicyclic alkenes using an asymmetric copper-catalysed Kharasch-Sosnovsky reaction has been explored. Good yields and reasonable levels of induction (up to 70% ee) have been obtained using carbocyclic systems as substrates. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.10.093

文献信息

• Therapeutic compounds
  申请人：——

  公开号：US20030232827A1

  公开（公告）日：2003-12-18

  This invention to antagonists that inhibit transporters and receptors. The invention also relates to partial inhibitors of transporters and receptors that allow partial transport or partial binding of a compound to the transporter or receptor. The invention also relates to compounds that differentially prevent transport or binding through a transporter or to a receptor. The invention also relates to the use of these compounds for treating certain diseases and disorders.

  这项发明涉及抑制转运体和受体的拮抗剂。该发明还涉及部分抑制剂，允许化合物部分转运或部分结合到转运体或受体。该发明还涉及不同程度地阻止通过转运体或受体的转运或结合的化合物。该发明还涉及利用这些化合物治疗某些疾病和疾病。
• Hydroxamic and carboxylic acid derivatives
  申请人：——

  公开号：US20030022893A1

  公开（公告）日：2003-01-30

  The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with matrix metalloproteinase, ADAM or ADAM-TS enzymes, a condition that is mediated by TNF &agr; or a condition involving a membrane-shedding event that is mediated by a metalloproteinase. Compounds of the invention are of formula I (B) 2 N—X—(CH 2 ) m -W-(CR 1 R 2 ) n —COY  (I) wherein n=0 or 1; m=0 or 1; X is S(O) 1-2 ; Y is OH or NHOH; W is aryl or heteroaryl; and the other groups are as defined herein.

  本发明涉及用于治疗与基质金属蛋白酶、ADAM或ADAM-TS酶相关的疾病、由TNFα介导的疾病或由金属蛋白酶介导的膜剥离事件相关的疾病的方法和化合物。本发明的化合物的化学式为I（B）2N—X—（CH2）m-W-（CR1R2）n—COY（I），其中n=0或1；m=0或1；X为S（O）1-2；Y为OH或NHOH；W为芳基或杂环芳基；其他基团如本文所定义。
• THERAPEUTIC COMPOUNDS
  申请人：Meltzer Peter C.

  公开号：US20090048284A1

  公开（公告）日：2009-02-19

  This invention to antagonists that inhibit transporters and receptors. The invention also relates to partial inhibitors of transporters and receptors that allow partial transport or partial binding of a compound to the transporter or receptor. The invention also relates to compounds that differentially prevent transport or binding through a transporter or to a receptor. The invention also relates to the use of these compounds for treating certain diseases and disorders.

  该发明涉及抑制转运体和受体的拮抗剂。该发明还涉及部分转运体和受体的抑制剂，允许化合物部分转运或部分结合到转运体或受体。该发明还涉及差异性地防止通过转运体或受体的转运或结合的化合物。该发明还涉及使用这些化合物治疗某些疾病和障碍。
• THERAPEUTIC AGENT FOR SENILE DEMENTIA
  申请人：Dainippon Sumitomo Pharma Co., Ltd.

  公开号：EP1637530A1

  公开（公告）日：2006-03-22

  A therapeutic/preventive agent for cognitive dysfunctions, which comprises as an active ingredient an imide derivative of the following formula [1]: wherein Z is a group of the formula [2]: D is a group of -(CH2)p-A-(CH2)q-; G is =N-, -CH-, etc.; and Ar is an aromatic heterocyclic group, etc.

  一种治疗/预防认知功能障碍的制剂，其活性成分包括下式[1]的亚胺衍生物： 其中 Z 是式 [2] 的基团： D是-(CH2)p-A-(CH2)q-的基团；G是＝N-、-CH-等；Ar是芳香杂环基团等。
• Therapeutic agent for senile dementia
  申请人：Ohno Yukihiro

  公开号：US20060142276A1

  公开（公告）日：2006-06-29

  A therapeutic/preventive agent for cognitive dysfunctions, which comprises as an active ingredient an imide derivative of the following formula [1]: wherein Z is a group of the formula [2]: D is a group of —(CH 2 ) p —A—(CH 2 ) q —; G is =N—, —CH—, etc.; and Ar is an aromatic heterocyclic group, etc.

  一种认知功能障碍的治疗/预防剂，其活性成分包括下式[1]的亚胺衍生物： 其中 Z 是式 [2] 的基团： D 是-(CH 2 ) p -A-(CH 2 ) q -；G 为 =N-、-CH- 等；Ar 为芳香杂环基团等。