2-methyl-2-tridecanol | 32836-44-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-methyl-2-tridecanol
• 英文别名: 2-methyltridecan-2-ol
• CAS: 32836-44-5
• 化学式: C₁₄H₃₀O
• 分子量: 214.392
• InChiKey: DWXTVLYIFYZGFY-UHFFFAOYSA-N

物化性质

• 沸点：
  265.7±8.0 °C(Predicted)
• 密度：
  0.833±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-methyl-2-tridecanol 在 甲烷磺酸 、 三乙胺 作用下， 以 四氯化碳 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Structure–activity relationships for 1′,1′-dimethylalkyl-Δ 8 -tetrahydrocannabinols

  摘要：

  A series of 1',1'-dimethylalkyl-Delta(8)-tetrahydrocannabinol analogues with C-3 side chains of 2-12 carbon atoms has been synthesized and their in vitro and in vivo pharmacology has been evaluated. The lowest member of the series, 1',1'-dimethylethyl-Delta(8)-THC (8, n = 0) has good affinity for the CB1 receptor, but is inactive in vivo. The dimethylpropyl (8, n = 1) through dimethyldecyl (8, n = 8) all have high affinity for the CB1 receptor and are full agonists in vivo. 1',1'-Dimethylundecyl-Delta(8)-THC (8, n = 9) has significant affinity for the receptor (K-i = 25.8 +/- 5.8 nM), but has reduced potency in vivo. The dodecyl analogue (8, n = 10) has little affinity for the CB1 receptor and is inactive in vivo. A quantitative structure-activity relationship study of the side chain region of these compounds is consistent with the concept that for optimum affinity and potency the side chain must be of a length which will permit its terminus to loop back in proximity to the phenolic ring of the cannabinoid. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(02)00649-1
• 作为产物：
  描述：

  在 硫酸 作用下， 以 乙醚 、 水 为溶剂， 生成 2-methyl-2-tridecanol
  参考文献：
  名称：

  一种阴离子表面活性剂的制备

  摘要：

  本发明涉及一种阴离子表面活性剂的制备本发明涉及一种阴离子表面活性剂的制备。以月桂醇、丙酮、硫酸等试剂为原料，首先制备溴代烷烃，溴代烷与镁反应得到格式试剂。其次，制备的格式试剂通过加成反应得到叔醇，最后通过取代反应合成表面活性剂。其特征在于，此表面活性剂与磺酸基团相连的碳原子是叔碳原子，不含α‑H，化学活性比较低，在应用过程中不与抗氧化剂发生反应，有良好的复配性，是一种具有良好应用前景的低活性表面活性剂。

  公开号：

  CN116969865A

文献信息

• A Facile Method for Synthesis of Alkyl Phenyl Selenides. The Reaction of Diphenyl Diselenide with Oxygen-containing Compounds Using La/Me₃SiCl/^cat.I₂/^cat.CuI System
  作者：Toshiki Nishino、Yutaka Nishiyama、Noboru Sonoda

  DOI：10.1246/cl.2003.918

  日期：2003.10

  Alcohols, ethers, and esters were directly converted to the corresponding alkyl phenyl selenides by the reaction of diphenyl diselenide and the La/Me3SiCl/cat.I2/cat.CuI. It was suggested that alkyl phenyl selenides were formed by the SH2 type reaction of diphenyl diselenide with alkyl radicals generated from alcohols, ethers or esters.

  通过二苯基二硒化物和 La/Me3SiCl/cat.I2/cat.CuI 的反应，醇、醚和酯直接转化为相应的烷基苯基硒化物。有人提出烷基苯基硒化物是由二苯基二硒化物与醇、醚或酯产生的烷基自由基的SH2型反应形成的。
• Deoxygenative Dimerization of Benzylic and Allylic Alcohols, and Their Ethers and Esters Using Lanthanum Metal and Chlorotrimethylsilane in the Presence of a Catalytic Amount of Iodine and Copper(I) Iodide
  作者：Toshiki Nishino、Yutaka Nishiyama、Noboru Sonoda

  DOI：10.1246/bcsj.76.635

  日期：2003.3

  Benzylic and allylic alcohols were deoxygenatively dimerized by a treatment with lanthanum metal and chlorotrimethylsilane in the presence of a catalytic amount of iodine, giving the corresponding coupling products, alkanes, in moderate-to-good yields. This dimerization reaction was dramatically accelerated by the addition of a catalytic amount of copper(I) iodide. Similarly, ethers and esters were

  在催化量的碘存在下，通过用镧金属和三甲基氯硅烷处理使苄醇和烯丙醇脱氧二聚，得到相应的偶联产物，烷烃，产率中等至良好。通过添加催化量的碘化铜 (I)，这种二聚反应显着加速。类似地，醚和酯在催化量的 H2O 存在下通过 La/Me3SiCl/cat.I2/cat.CuI 系统脱氧二聚。
• CLEAVABLE SURFACTANTS
  申请人：Saveliev Sergei

  公开号：US20090095628A1

  公开（公告）日：2009-04-16

  The invention provides surfactant compounds of formulas I-IX, which can be used in methods for aiding the solubilization, digestion, preparation, analysis, and/or characterization of biological material, for example, proteins or cell membranes. The compounds can also aid in the recovery of peptides generated during protein digestion, particularly for in-gel digestion protocol. Additionally, the compounds can improve enzymatic protein deglycosylation without interfering with downstream sample preparation steps and mass spectrometric analysis. The compounds can be specifically useful as digestion aids that can be decomposed by an acid, by heat, or a combination thereof. Decomposition of the surfactants allows for facile separation from isolated samples, and/or allows for analysis of the sample without interfering with the sensitivity of various analytical techniques.

  这项发明提供了公式I-IX的表面活性剂化合物，可以用于辅助溶解、消化、制备、分析和/或表征生物材料，例如蛋白质或细胞膜。这些化合物还可以帮助恢复在蛋白质消化过程中产生的肽段，特别是在凝胶内消化方案中。此外，这些化合物可以改善酶促蛋白质去糖基化的效果，而不会干扰下游样品制备步骤和质谱分析。这些化合物作为消化辅助剂特别有用，可以通过酸、热或二者的组合来分解。表面活性剂的分解使得可以轻松地与分离的样品分离，和/或允许对样品进行分析，而不会干扰各种分析技术的灵敏度。
• A Grignard-Type Phase-Vanishing Method: Generation of Organomagnesium Reagent and Its Subsequent Addition to Carbonyl Compounds
  作者：Hiroshi Matsubara、Yuki Niwa、Ryosuke Matake

  DOI：10.1055/s-0034-1380381

  日期：——

  A quadraphasic phase-vanishing system comprised of diethyl ether, magnesium, perfluoropolyether, and iodoalkane efficiently generated the corresponding Grignard reagents, which subsequently added to carbonyl compounds in the ether layer to afford alkylated alcohols in good yields.

  由乙醚、镁、全氟聚醚和碘代烷烃组成的四相相消失系统有效地生成了相应的格氏试剂，随后将其添加到醚层中的羰基化合物中，以良好的收率提供烷基化醇。
• Formation of allylated quaternary carbon centers <i>via</i> C–O/C–O bond fragmentation of oxalates and allyl carbonates
  作者：Haifeng Chen、Yang Ye、Weiqi Tong、Jianhui Fang、Hegui Gong

  DOI：10.1039/c9cc07072a

  日期：——

  emphasizes Fe-promoted cross-electrophile allylation of tertiary alkyl oxalates with allyl carbonates that generates all C(sp3)-quaternary centers. The reaction involves fragmentation of tertiary alkyl oxalate C-O bonds to give tertiary alkyl radical intermediates, addition of the radicals to less hindered alkene terminals, and subsequent cleavage of the allyl C-O bonds. Allylation with 2-aryl substituted

  本文公开的重点在于草酸叔烷基酯与碳酸烯丙酯的铁促进的交亲电子烯丙基化，该烯丙基碳酸酯生成所有C（sp3）-季铵盐中心。该反应涉及草酸叔烷基酯CO键的断裂，得到叔烷基自由基中间体，将该基团加到受阻较小的烯烃末端，以及随后烯丙基CO键的断裂。Zn / MgCl2介导2-芳基取代的碳酸烯丙酯的烯丙基化，Fe用于提高自由基的加成效率。通过引入活化的烯烃，发生了三组分自由基级联反应。