7-methyl-6-octenoic acid | 90646-70-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 7-methyl-6-octenoic acid
• 英文别名: 7-methyl-oct-6-enoic acid；7-Methyl-oct-6-ensaeure；7-Methyl-octen-(6)-saeure；7-methyloct-6-enoic acid
• CAS: 90646-70-1
• 化学式: C₉H₁₆O₂
• 分子量: 156.225
• InChiKey: SVYSJXSNGHDZPQ-UHFFFAOYSA-N

物化性质

• 沸点：
  99-101 °C(Press: 0.7 Torr)
• 密度：
  0.945±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7-methyl-6-octenoic acid 在 sodium hydroxide 、 氯化亚砜 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 5.0h， 生成 N-(2-iodophenyl)-7-methyl-6-octenamide
  参考文献：
  名称：

  Amide-based protecting/radical translocating (PRT) groups. Generation of radicals adjacent to carbonyls by 1,5-hydrogen transfer reactions of o-iodoanilides

  摘要：

  The o-iodoanilide group is shown to be broadly useful for the generation and subsequent reactions of radicals adjacent to carboxyl groups. The results indicate that this group is one of the best ''protecting/radical translocating'' (PRT) groups introduced to date. Beyond its good performance in radical translocation reactions, it is easy to introduce, serves as a reasonable protecting group both before and after the translocation, and (with appropriate modifications) is easy to remove.

  DOI：

  10.1016/s0040-4020(01)90466-1
• 作为产物：
  描述：

  5-甲基-4-己烯酸 在 lithium aluminium tetrahydride 、 正丁基锂 、 sodium hydride 、 三乙胺 、 二异丙胺 、 sodium iodide 作用下， 以 乙醚 、 二氯甲烷 、 丙酮 为溶剂， 反应 23.25h， 生成 7-methyl-6-octenoic acid
  参考文献：
  名称：

  Amide-based protecting/radical translocating (PRT) groups. Generation of radicals adjacent to carbonyls by 1,5-hydrogen transfer reactions of o-iodoanilides

  摘要：

  The o-iodoanilide group is shown to be broadly useful for the generation and subsequent reactions of radicals adjacent to carboxyl groups. The results indicate that this group is one of the best ''protecting/radical translocating'' (PRT) groups introduced to date. Beyond its good performance in radical translocation reactions, it is easy to introduce, serves as a reasonable protecting group both before and after the translocation, and (with appropriate modifications) is easy to remove.

  DOI：

  10.1016/s0040-4020(01)90466-1

文献信息

• Diastereoselective atom transfer radical cyclization reactions of unsaturated α-bromo oxazolidinone imides catalyzed by Lewis acids
  作者：Dan Yang、Bao-Fu Zheng、Shen Gu、Philip W.H. Chan、Nian-Yong Zhu

  DOI：10.1016/j.tetasy.2003.06.001

  日期：2003.10

  A new Lewis acid-catalyzed atom transfer radical cyclization reaction of unsaturated α-bromo oxazolidinone imides is reported. In the presence of Lewis acids such as Mg(ClO4)2 and Yb(OTf)3, a series of trans cyclic products was obtained in high yield (up to 87%) between 0°C and room temperature. The loading of strong Lewis acids, such as Yb(OTf)3, can be reduced to 0.1 equiv. without significantly

  报道了一种新的路易斯酸催化的不饱和α-溴恶唑烷二酮酰亚胺的原子转移自由基环化反应。在路易斯酸如Mg（ClO 4）2和Yb（OTf）3的存在下，可以在0℃至室温之间以高收率（高达87％）获得一系列反式环产物。强路易斯酸（例如Yb（OTf）3）的负载量可以降低到0.1当量。而不会显着降低产量。通过使用1,2-立体控制或手性恶唑烷酮助剂可以实现出色的非对映选择性。对于带有β-甲基取代基和手性助剂的底物1e和1f，（S）-（-）-4-苄基-5,5-二甲基-2-恶唑烷酮，产物的非对映异构体比率大于50：1。
• Intermolecular Enolate Heterocoupling: Scope, Mechanism, and Application
  作者：Michael P. DeMartino、Ke Chen、Phil S. Baran

  DOI：10.1021/ja804159y

  日期：2008.8.27

  while iron(III)-based couplings appear to proceed through a non-templated heterodimerization. This work presents the most in-depth findings on the mechanism of oxidative enolate coupling to date. The scope of oxidative enolate heterocoupling is extensive (40 examples) and has been shown to be efficient even on a large scale (gram-scale or greater). Finally, the method has been applied to the total synthesis

  这篇完整的报告介绍了两种不同羰基物质的氧化分子间偶联的背景、发现和广泛的见解。该过程的优化最终形成了使用可溶性铜 (II) 或铁 (III) 盐作为氧化剂将酰胺、酰亚胺、酮和羟吲哚结合的可靠且可扩展的方案。广泛的机理研究表明，在铜 (II) 的情况下是金属螯合的单电子转移过程，而基于铁 (III) 的偶联似乎是通过非模板化的异二聚化进行的。这项工作提供了迄今为止对氧化烯醇偶联机制最深入的发现。氧化烯醇杂偶联的范围很广（40 个例子），并且已被证明即使在大规模（克级或更大）上也是有效的。最后，
• PERFUME SYSTEMS
  申请人：The Procter & Gamble Company

  公开号：EP3085759A2

  公开（公告）日：2016-10-26

  The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.

  本申请涉及香水原料、香水输送系统和包含此类香水原料和/或此类香水输送系统的消费品，以及制造和使用此类香水原料、香水输送系统和消费品的工艺。本文公开的香水原料和组合物，包括香水输送系统，扩大了香水界的选择范围，因为这些香水原料可以提供不同的特性，而这些组合物可以提供所需的气味特征。
• 602. Reduced cyclic compounds. Part IV. The intramolecular acylation of some olefinic acids
  作者：M. F. Ansell、S. S. Brown

  DOI：10.1039/jr9580002955

  日期：——
• Beckmann Rearrangements in Alicyclic Systems. III. 2,2-Dimethylcycloalkanone Oximes^1,2
  作者：Robert T. Conley、Bernard E. Nowak

  DOI：10.1021/jo01056a050

  日期：1962.9