4-oxo-N-(pyridin-3-yl)-2-(3-(trifluoromethyl)phenyl)-4H-chromene-8-carboxamide | 1219444-71-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 4-oxo-N-(pyridin-3-yl)-2-(3-(trifluoromethyl)phenyl)-4H-chromene-8-carboxamide
• 英文别名: 4-oxo-N-pyridin-3-yl-2-[3-(trifluoromethyl)phenyl]chromene-8-carboxamide
• CAS: 1219444-71-9
• 化学式: C₂₂H₁₃F₃N₂O₃
• 分子量: 410.352
• InChiKey: AGHYGEXDFVPGPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  68.3
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  3-氨基吡啶 、 4-oxo-2-(3-(trifluoromethyl)phenyl)-4H-chromene-8-carboxylic acid 在 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以23%的产率得到4-oxo-N-(pyridin-3-yl)-2-(3-(trifluoromethyl)phenyl)-4H-chromene-8-carboxamide
  参考文献：
  名称：

  [EN] CHROMENONE ANALOGS AS SIRTUIN MODULATORS
  [FR] ANALOGUES DE CHROMÉNONE EN TANT QUE MODULATEURS DE SIRTUINE

  摘要：

  公开号：

  WO2010037127A8

文献信息

• CHROMENONE ANALOGS AS SIRTUIN MODULATORS
  申请人：Oalmann Christopher

  公开号：US20110257174A1

  公开（公告）日：2011-10-20

  Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

  本文提供了新型的调节sirtuin的化合物及其使用方法。这些sirtuin调节化合物可用于延长细胞寿命，治疗和/或预防各种疾病和障碍，包括与衰老或压力相关的疾病或障碍、糖尿病、肥胖症、神经退行性疾病、心血管疾病、血液凝块障碍、炎症、癌症和/或潮红，以及需要增加线粒体活性的疾病或障碍。还提供了包含sirtuin调节化合物与另一种治疗剂组合的组合物。
• Chromenone analogs as sirtuin modulators
  申请人：Oalmann Christopher

  公开号：US08987258B2

  公开（公告）日：2015-03-24

  The present invention relates to novel chromenone analog sirtuin modulator compounds of Formula (I): or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions and treatment methods and combination therapies thereof for use in increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity.

  本发明涉及一种新型的色酮类似物sirtuin调节剂化合物（I）及其药学上可接受的盐，相应的药物组合和治疗方法，用于增加细胞寿命，治疗和/或预防各种疾病和疾病，包括与衰老或应激有关的疾病或疾病，糖尿病，肥胖症，神经退行性疾病，心血管疾病，血液凝块病，炎症，癌症和/或潮红以及从增加线粒体活性中受益的疾病或疾病。
• US8987258B2
  申请人：——

  公开号：US8987258B2

  公开（公告）日：2015-03-24
• [EN] CHROMENONE ANALOGS AS SIRTUIN MODULATORS<br/>[FR] ANALOGUES DE CHROMÉNONE EN TANT QUE MODULATEURS DE SIRTUINE
  申请人：SIRTRIS PHARMACEUTICALS INC

  公开号：WO2010037127A8

  公开（公告）日：2011-03-10