(E)-4-methyl-2-hexenamide | 1224737-66-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (E)-4-methyl-2-hexenamide
• 英文别名: (E)-4-methylhex-2-enamide
• CAS: 1224737-66-9
• 化学式: C₇H₁₃NO
• 分子量: 127.186
• InChiKey: YGXPYUPSKSQXSO-SNAWJCMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-甲基丁醛 、 二氯乙酰胺 在 三氢化钐 、 二碘甲烷 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以56%的产率得到(E)-4-methyl-2-hexenamide
  参考文献：
  名称：

  具有完全立体选择性的（E）-α，β-不饱和伯酰胺的顺序合成†

  摘要：

  报道了（E）-α，β-不饱和伯酰胺的新颖，有效且完全立体选择性的合成。该过程与未掩蔽的氯乙酰胺mar烯酸酯与醛的SmI 2介导的顺序反应一致，然后进行β-消除，以高收率生产（E）-α，β-不饱和伯酰胺。

  DOI：

  10.1021/jo100320j

文献信息

• COMPOSITIONS FOR TREATING OR PREVENTING OBESITY AND INSULIN RESISTANCE DISORDERS
  申请人：Sinclair David A.

  公开号：US20120029065A1

  公开（公告）日：2012-02-02

  Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.

  本文提供了一种调节sirtuin活性或水平的方法和组合物，从而治疗或预防主体的肥胖症或胰岛素抵抗性疾病，如糖尿病。示例方法包括使用sirtuin激活化合物或抑制性化合物与细胞接触，从而分别增加或减少脂肪积累。
• Treatment of eye disorders with sirtuin modulators
  申请人：Milburn Michael

  公开号：US20070014833A1

  公开（公告）日：2007-01-18

  Sirtuin modulators, particularly sirtuin activators, are useful in treating vision impairment. In general, the sirtuin modulators inhibit the progression of vision impairment resulting from various eye disorders. The invention also includes pharmaceutically acceptable formulations of sirtuin modulators, particular ophthalmically acceptable formulations.
• Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders
  申请人：Milburn Michael

  公开号：US20070149466A1

  公开（公告）日：2007-06-28

  Provided herein are methods and compositions for treating or preventing metabolic disorders, such as obesity and diabetes. Methods may comprise modulating the activity or level of a sirtuin, such as SIRT1 or Sir2. Exemplary methods comprise contacting a cell with a sirtuin activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin, or an inhibitory compound, such as nicotinamide.
• Cognitive Performance With Sirtuin Activators
  申请人：Sinclair David A.

  公开号：US20080194803A1

  公开（公告）日：2008-08-14

  Provided herein are methods and compositions for enhancing the cognitive performance of a subject in need thereof. A method may include administering to a subject an agent that increases the level of protein or activity of a sirtuin, such as SIRT1.
• METHODS AND COMPOSITIONS FOR ENHANCING LIFESPAN INVOLVING SIRTUIN-MODULATING COMPOUNDS AND CHALCOGENIDES
  申请人：Roth Mark B.

  公开号：US20120135091A1

  公开（公告）日：2012-05-31

  The present invention concerns the use of active compounds, including chalcogenides and sirtuin-modulating compounds, either alone or in combination for increasing or enhancing survivability and/or longevity in biological matter. In general aspects, the chalcogenides and other active compounds may modulate one or more sirtuin proteins. It includes compositions, methods, articles of manufacture and apparatuses for enhancing survivability in any of these biological materials, so as to preserve and/or protect them. In specific embodiments, there are also therapeutic methods and apparatuses for aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia, and cancer using the active compounds described.