2-Methyl-1-(4-propan-2-yloxyphenyl)benzimidazol-5-amine | 911137-89-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-Methyl-1-(4-propan-2-yloxyphenyl)benzimidazol-5-amine
• CAS: 911137-89-8
• 化学式: C₁₇H₁₉N₃O
• 分子量: 281.357
• InChiKey: MGPPUKORNUKQJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  53.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 5-(4-chlorophenyl)-3-{[(1E)-(dimethylamino)methylidene]amino}-2-thiophenecarboxylate 、 2-Methyl-1-(4-propan-2-yloxyphenyl)benzimidazol-5-amine 在 苯酚 作用下， 生成 6-(4-Chlorophenyl)-3-[2-methyl-1-(4-propan-2-yloxyphenyl)benzimidazol-5-yl]thieno[3,2-d]pyrimidin-4-one
  参考文献：
  名称：

  Novel benzimidazole-based MCH R1 antagonists

  摘要：

  The identification of an MCH R1 antagonist screening hit led to the optimization of a class of benzimidazole-based MCH R1 antagonists. Structure-activity relationships and efforts to optimize pharmacokinetic properties are detailed along with the demonstration of the effectiveness of an MCH R1 antagonist in an animal model of obesity. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.07.054
• 作为产物：
  描述：

  2,4-二硝基氟苯 在 palladium on activated charcoal 盐酸 、 氢气 、 potassium carbonate 、 三乙胺 作用下， 以 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 生成 2-Methyl-1-(4-propan-2-yloxyphenyl)benzimidazol-5-amine
  参考文献：
  名称：

  Novel benzimidazole-based MCH R1 antagonists

  摘要：

  The identification of an MCH R1 antagonist screening hit led to the optimization of a class of benzimidazole-based MCH R1 antagonists. Structure-activity relationships and efforts to optimize pharmacokinetic properties are detailed along with the demonstration of the effectiveness of an MCH R1 antagonist in an animal model of obesity. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.07.054

文献信息

• Novel benzimidazole-based MCH R1 antagonists
  作者：Andrew J. Carpenter、Kamal A. Al-Barazanji、Kevin K. Barvian、Michael J. Bishop、Christy S. Britt、Joel P. Cooper、Aaron S. Goetz、Mary K. Grizzle、Donald L. Hertzog、Diane M. Ignar、Ronda O. Morgan、Gregory E. Peckham、Jason D. Speake、Will R. Swain

  DOI：10.1016/j.bmcl.2006.07.054

  日期：2006.10

  The identification of an MCH R1 antagonist screening hit led to the optimization of a class of benzimidazole-based MCH R1 antagonists. Structure-activity relationships and efforts to optimize pharmacokinetic properties are detailed along with the demonstration of the effectiveness of an MCH R1 antagonist in an animal model of obesity. (c) 2006 Elsevier Ltd. All rights reserved.