5-O-磷羧基-2-C-[(磷羧基氧代)甲基]-D-核酸 | 27442-42-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 5-O-磷羧基-2-C-[(磷羧基氧代)甲基]-D-核酸
• 中文别名: 2-羧基阿拉伯糖醇1,5-二磷酸酯
• 英文名称: 2-Carboxyarabinitol-1,5-diphosphate
• 英文别名: (2R,3R,4R)-2,3,4-trihydroxy-5-phosphonooxy-2-(phosphonooxymethyl)pentanoic acid
• CAS: 27442-42-8
• 化学式: C₆H₁₄O₁₃P₂
• 分子量: 356.11
• InChiKey: ITHCSGCUQDMYAI-ZMIZWQJLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.8
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  232
• 氢给体数：
  8
• 氢受体数：
  13

文献信息

• Process for generation of protein and uses thereof
  申请人：The Australian National University

  公开号：EP2631241A2

  公开（公告）日：2013-08-28

  A method of generating a protein with an improved functional property, the method comprising: (a) identifying at least one Target amino acid Residue in a first protein, wherein said Target amino acid Residue is associated with said functional property; (b) comparing at least one homologous second protein from the same or a different phylogenetic branch as the first protein with the first protein and identifying at least one Variant amino acid Residue between the first protein and the second protein; (c) selecting at least one Candidate amino acid Residue from the Variant amino acid Residue identified in (b) on the basis of said Candidate amino acid Residue affecting said Target amino acid Residue with respect to said functional property; (d) forming at least one Candidate Mutant protein in silico or producing at least one Candidate Mutant protein in vitro in which said at least one Candidate amino acid Residue from the second protein substitutes a corresponding residue in the first protein; and (e) screening said at least one Candidate Mutant protein produced in (d) to identify a protein having said improved functional property.

  一种生成具有改进功能特性的蛋白质的方法，该方法包括(a) 识别第一种蛋白质中的至少一个目标氨基酸残基，其中所述目标氨基酸残基与所述功能特性相关； (b) 将与第一种蛋白质来自相同或不同系统发育分支的至少一个同源第二种蛋白质与第一种蛋白质进行比较，并识别第一种蛋白质与第二种蛋白质之间的至少一个变异氨基酸残基；(c) 根据所述候选氨基酸残基在所述功能特性方面对所述目标氨基酸残基的影响，从(b)中确定的变异氨基酸残基中选择至少一个候选氨基酸残基；(d) 在硅学中形成至少一种候选突变蛋白，或在体外产生至少一种候选突变蛋白，其中第二种蛋白中的至少一种候选氨基酸残基取代第一种蛋白中的相应残基；以及 (e) 筛选(d)中产生的至少一种候选突变蛋白，以鉴定出具有所述改进功能特性的蛋白。
• Ribulose 1,5-bisphosphate carboxylase/oxygenase polypeptides and related polynucleotides
  申请人：——

  公开号：US20040038262A1

  公开（公告）日：2004-02-26

  The present invention relates to novel ribulose-1,5-bisphosphate carboxylase/oxygenase polypeptides and the polynucleotides that encode them. The invention also provides related host cells and methods.

  本发明涉及新型核酮糖-1,5-二磷酸羧化酶/氧合酶多肽和编码它们的多核苷酸。本发明还提供了相关的宿主细胞和方法。
• PROCESS FOR GENERATION OF PROTEIN AND USES THEREOF
  申请人：The Australian National University

  公开号：EP2079755A1

  公开（公告）日：2009-07-22
• METHODS OF IDENTIFYING AND CREATING RUBISCO LARGE SUBUNIT VARIANTS WITH IMPROVED RUBISCO ACTIVITY, COMPOSITIONS AND METHODS OF USE THEREOF
  申请人：ZHU GENHAI

  公开号：US20080256666A1

  公开（公告）日：2008-10-16

  Methods for identifying one or more amino acid substitutions in a Rubisco large subunit polypeptide (variant) that confer increased Rubisco activity in a unicellular photosynthetic organism and transferring those substitutions to a Rubisco large subunit polypeptide of a higher plant cell are described herein. Methods and compositions for modulating plant productivity using the modified Rubisco large subunit polypeptide variants are provided. The Rubisco large subunit sequences are used in a variety of methods including increasing plant productivity in a plant. Transformed plants, plant cell, tissues, seed, and expression vectors are also provided.
• RIBULOSE, 1,5-BISPHOSPHATE CARBOXYLASE/OXYGENASE POLYPEPTIDES AND RELATED POLYNUCLEOTIDES
  申请人：CHATTERJEE Ranjini

  公开号：US20090162895A1

  公开（公告）日：2009-06-25

  The present invention relates to novel ribulose-1,5-bisphosphate carboxylase/oxygenase polypeptides and the polynucleotides that encode them. The invention also provides related host cells and methods.