ethyl (2-(N-(4-chlorophenyl)-4-nitrobenzamido)-2-(2-chloroquinolin-3-yl)acetamido)acetate | 1456629-18-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl (2-(N-(4-chlorophenyl)-4-nitrobenzamido)-2-(2-chloroquinolin-3-yl)acetamido)acetate
• 英文别名: ethyl 2-[[2-(4-chloro-N-(4-nitrobenzoyl)anilino)-2-(2-chloroquinolin-3-yl)acetyl]amino]acetate
• CAS: 1456629-18-7
• 化学式: C₂₈H₂₂Cl₂N₄O₆
• 分子量: 581.412
• InChiKey: AVUDTLHVUPWLAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  40
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  134
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-氯-3-喹啉甲醛 、 异氰基乙酸乙酯 、 对氯苯胺 、 对硝基苯甲酸 在 calcium fluoride 作用下， 以 乙醇 为溶剂， 反应 0.05h， 以92%的产率得到ethyl (2-(N-(4-chlorophenyl)-4-nitrobenzamido)-2-(2-chloroquinolin-3-yl)acetamido)acetate
  参考文献：
  名称：

  Microwave-Assisted One-Pot Synthesis of Bioactive UGI-4CR Using Fluorite as Benign and Heterogeneous Catalyst

  摘要：

  Fluorite has been used as an activating heterogeneous catalyst for a rapid and facile one-pot synthesis of biologically active Ugi four-component reaction (Ugi-4CR) under microwave irradiation in good to moderate yields with short reaction times. The catalyst is environmentally benign, commercially available, and reusable several times with no reduction in its efficiency. The resulting Ugi derivatives 5(a-h) were characterized on the basis of H-1 and C-13 NMR, infrared, elemental analysis, and mass spectral data. The synthesized moieties were screened for their potential antibacterial activities in vitro against a few microorganisms: Staphylococcus aureus (Gram positive), Bacillus subtilis (Gram positive), Escherichia coli (Gram negative), and Proteus vulgaris (Gram negative). The screening data show that compounds 5a, 5c, 5e, and 5h are highly active against the strains. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]

  DOI：

  10.1080/00397911.2013.781184

文献信息

• Microwave-Assisted One-Pot Synthesis of Bioactive UGI-4CR Using Fluorite as Benign and Heterogeneous Catalyst
  作者：Ipsita Mohanram、Jyotsna Meshram、Ambareen Shaikh、Bhavna Kandpal

  DOI：10.1080/00397911.2013.781184

  日期：2013.12.17

  Fluorite has been used as an activating heterogeneous catalyst for a rapid and facile one-pot synthesis of biologically active Ugi four-component reaction (Ugi-4CR) under microwave irradiation in good to moderate yields with short reaction times. The catalyst is environmentally benign, commercially available, and reusable several times with no reduction in its efficiency. The resulting Ugi derivatives 5(a-h) were characterized on the basis of H-1 and C-13 NMR, infrared, elemental analysis, and mass spectral data. The synthesized moieties were screened for their potential antibacterial activities in vitro against a few microorganisms: Staphylococcus aureus (Gram positive), Bacillus subtilis (Gram positive), Escherichia coli (Gram negative), and Proteus vulgaris (Gram negative). The screening data show that compounds 5a, 5c, 5e, and 5h are highly active against the strains. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]