5-S-乙基-5-硫代核糖 | 53458-56-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 5-S-乙基-5-硫代核糖
• 英文名称: 5-Ethylthioribose
• 英文别名: (2R,3S,4S)-5-ethylsulfanyl-2,3,4-trihydroxypentanal
• CAS: 53458-56-3
• 化学式: C₇H₁₄O₄S
• 分子量: 194.25
• InChiKey: NMPVNCCANBILIA-XVMARJQXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  103
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 海关编码：
  2930909090

文献信息

• Transition state sturcture of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases
  申请人：Schramm Vern L.

  公开号：US20110086812A1

  公开（公告）日：2011-04-14

  Provided are methods of designing a putative inhibitor of a 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase. The methods comprise designing a chemically stable compound that resembles the charge and geometry of the 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase transition state. Also provided are methods of inhibiting 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidases using the inhibitors found by the above methods.

  提供了一种设计假想抑制剂5'-甲基硫腺苷/ S-腺苷基高同型半胱氨酸核苷酸酶的方法。该方法包括设计一种化学稳定的化合物，其类似于5'-甲基硫腺苷/ S-腺苷基高同型半胱氨酸核苷酸酶过渡态的电荷和几何形状。此外，还提供了使用上述方法发现的抑制剂抑制5'-甲基硫腺苷/ S-腺苷基高同型半胱氨酸核苷酸酶的方法。
• Methylthioribose analogues, their preparation and use as medicinal agents and biocides
  申请人：STATE OF OREGON BY AND THROUGH OREGON STATE BOARD OF HIGHER EDUCATION ON BEHALF OREGON HEALTH SC. UNIV. AND OREGON STATE UNIV.

  公开号：EP0233031A2

  公开（公告）日：1987-08-19

  Compounds of the formula: wherein R is H, Cl, F, Br, I or R₁S-, in which R₁ is C₁-C₁₀ linear or branched chain alkyl or halogenated linear or branched chain alkyl, and wherein R₂, R₃ and R₄ are the same or different and each is H- or -OH, with the proviso that at least one of R₂, R₃ and R₄ is hydroxy and the further proviso that when R₂, R₃ and R₄ are all OH, R₁ is other than methyl, are useful in inhibiting the growth or MTR kinase-dependent microorganisms and parasitic protazoans. The compounds are novel, except those wherien R₁ is methyl or isobutyl when R₂, R₃ and R₄ are all OH.

  式中的化合物： 其中 R 是 H、Cl、F、Br、I 或 R₁S-，其中 R₁ 是 C₁-C₁₀ 直链或支链烷基或卤代直链或支链烷基，以及 其中 R₂、R₃ 和 R₄ 相同或不同，且各自为 H- 或 -OH、 R₂、R₃和R₄中至少有一个是羟基，以及当R₂、R₃和R₄都是OH时，R₁不是甲基，这些限制条件有助于抑制依赖MTR激酶的微生物和寄生原虫的生长。除了 R₂、R₃和 R₄ 均为 OH 时 R₁ 为甲基或异丁基的化合物外，这些化合物都是新化合物。
• Ribose aids in plant hardening, in the recovery following transplantation shock, and enhances plant growth and yield and root growth
  申请人：——

  公开号：US20030217577A1

  公开（公告）日：2003-11-27

  The present invention relates to methods and compositions for supplementing the soil/diet of plants in order to enhance plant growth, yield, hardening, as well as the recovery of plants which undergo transplantation. The present invention provides ribose and other pentose sugars and their derivatives, alone or in combination with other carbohydrates, electrolytes, minerals, enzymes, micronutrients, macronutrients, or other ingredients to enhance plant growth, yield, hardening, and aid in the recovery during and following transplantation

  本发明涉及补充植物土壤/膳食的方法和组合物，以提高植物的生长、产量、硬化以及移栽植物的恢复能力。本发明提供核糖和其他戊糖及其衍生物，单独或与其他碳水化合物、电解质、矿物质、酶、微量营养素、宏量营养素或其他成分结合使用，以促进植物生长、产量、硬化，并帮助移植过程中和移植后的恢复。
• TRANSITION STATE STRUCTURE OF 5'-METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASES
  申请人：ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY, a division of YESHIVA UNIVERSITY

  公开号：EP1924684A2

  公开（公告）日：2008-05-28
• EP1924684A4
  申请人：——

  公开号：EP1924684A4

  公开（公告）日：2009-02-11