5-S-甲基-1-O-膦酰-5-硫代戊-2-纤维骨架 | 86316-83-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 5-S-甲基-1-O-膦酰-5-硫代戊-2-纤维骨架
• 英文名称: S-Methyl-5-thio-D-ribulose 1-phosphate
• 英文别名: [(3R,4S)-3,4-dihydroxy-5-methylsulfanyl-2-oxopentyl] dihydrogen phosphate
• CAS: 86316-83-8
• 化学式: C₆H₁₃O₇PS
• 分子量: 260.2
• InChiKey: CNSJRYUMVMWNMC-RITPCOANSA-N

物化性质

• 沸点：
  569.9±60.0 °C(Predicted)
• 密度：
  1.626±0.06 g/cm3(Predicted)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  150
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• Probe compound for detecting and isolating enzymes and means and methods using the same
  申请人：Helmholtz-Zentrum für Infektionsforschung GmbH

  公开号：EP2230312A1

  公开（公告）日：2010-09-22

  The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention. The immobilisation of the cognate substrates or metabolites on the surface of nanoparticles by means of the probe compounds allows capturing and isolating the respective enzyme, e.g. for subsequent sequencing.

  本发明涉及一种探针化合物，它可以包括酶反应的任何底物或代谢物，此外还包括指示成分，例如荧光染料或类似物。此外，本发明还涉及以阵列形式检测酶的方法，该阵列由任意数量的本发明探针化合物组成，每种探针化合物由代表所有生命形式中中心途径的相互关联的代谢物中的不同代谢物组成。此外，本发明还涉及一种检测酶的方法，该方法涉及将细胞提取物或类似物应用于本发明的阵列，从而导致与底物发生可重复的酶反应。这些特定的酶反应会触发指示剂（如荧光信号），并将酶与各自的同源底物结合。此外，本发明还涉及以涂覆有本发明探针化合物的纳米颗粒形式分离酶的方法。通过探针化合物将同源底物或代谢物固定在纳米颗粒表面，可以捕获和分离相应的酶，例如用于后续测序。
• Genes for enhancing drought and heat tolerance in plants and methods of use
  申请人：UT-Battelle, LLC

  公开号：US11041164B2

  公开（公告）日：2021-06-22

  The present disclosure provides methods for increasing drought resistance and heat resistance of a plant. The methods encompass expression of at least one heat shock protein (HSP) from the group consisting of HSP40, HSP60 or HSP70 together with a phosphoenolpyruvate carboxylase (PEPC) comprising an aspartic acid (D) at a position that corresponds to the position 509 of SEQ ID NO: 4, in the plant. In comparison to a plant not manipulated in this manner, the disclosed, genetically-modified, plants display improved drought resistance and heat resistance. Also provided are plants that can be obtained by the method according to the invention, and nucleic acid vectors to be used in the described methods.

  本公开提供了提高植物抗旱性和耐热性的方法。这些方法包括在植物中表达至少一种热休克蛋白（HSP），该蛋白由 HSP40、HSP60 或 HSP70 与磷酸烯醇丙酮酸羧化酶（PEPC）组成，其中磷酸烯醇丙酮酸羧化酶（PEPC）包含与 SEQ ID NO: 4 的 509 位相对应的天冬氨酸（D）。与未以这种方式操作的植物相比，所公开的转基因植物显示出更好的抗旱性和耐热性。本发明还提供了可通过本发明方法获得的植物，以及用于所述方法的核酸载体。
• COMPOSITIONS AND METHODS FOR MODELING BACILLUS SUBTILIS METABOLISM
  申请人：Genomatica, Inc.

  公开号：EP1490678A2

  公开（公告）日：2004-12-29
• EP1490678A4
  申请人：——

  公开号：EP1490678A4

  公开（公告）日：2007-01-03
• GENES FOR ENHANCING DROUGHT AND HEAT TOLERANCE IN PLANTS AND METHODS OF USE
  申请人：UT-Battelle, LLC

  公开号：US20180371487A1

  公开（公告）日：2018-12-27

  The present disclosure provides methods for increasing drought resistance and heat resistance of a plant. The methods encompass expression of at least one heat shock protein (HSP) from the group consisting of HSP40, HSP60 or HSP70 together with a phosphoenolpyruvate carboxylase (PEPC) comprising an aspartic acid (D) at a position that corresponds to the position 509 of SEQ ID NO: 4, in the plant. In comparison to a plant not manipulated in this manner, the disclosed, genetically-modified, plants display improved drought resistance and heat resistance. Also provided are plants that can be obtained by the method according to the invention, and nucleic acid vectors to be used in the described methods.